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자궁경부에 발생한 원발성 세포독성 T-세포 림프종 1예 : A case report
김지혜,곽재용,임창열 대한내과학회 2003 대한내과학회지 Vol.65 No.4
악성 림프종에서 자궁 경부로의 전이는 드물지 않지만 자궁 경부의 원발성 림프종은 드물다. 우연히 건강검진에서 발견하게된 병기 IE로 진단된 자궁경부의 T-세포 림프종 1 예를 보고하고 올바른 진단과 분류가 이루어지면 적절한 치료를 할 수 있고 이로 인해 성공적인 예후를 보일 수 있음을 강조한다. Non-Hodgkin's lymphoma can involve the gynecologic tract, most often as a manifestatiion of systemic involvement. Primary lymphomas of the female genital tract are rare. Most involve the cervix rather than the uterine corpus. All of those previously reported have been B-cell lymphomas, with the exception of several case reports. Primary T-cell lymphoma of the uterine cervix is rare. We describe a rare case of primary cytotoxic T-cell lymphoma of the uterine cervix, Ann Arbor stage IE in a 55-year-old woman. The tumor, incidentally disclosed at gynecological examination, appeared as diffuse cervical enlargement with mucosal erosion. A biopsy was taken and showed diffuse infiltration of variable sized lymphoma cells. Neoplastic cells were positive for LCA, CD3, TIA-1 and consistent with cytotoxic T-cell lymphoma. She was treated with 3 cycles of cyclophosphamide, doxorubicin, vincristine, and prednisolone(CHOP). After chemotherapy, the patient was treated by pelvic external radiation therapy. At present, the patient is well and disease-free.
Ji Hye Yim,김원배,Eui Young Kim,김원구,김태용,송영기 대한갑상선학회 2011 International Journal of Thyroidology Vol.4 No.2
Background and Objectives: Little has been known for factors predicting improvement of proptosis in patients with thyroid-associated ophthalmopathy (TAO) after intravenous (IV) glucocorticoid therapy. This study aimed to evaluate the efficacy of IV glucocorticoid therapy and to find factor predicting treatment outcomes in patients with TAO. Materials and Methods: Forty-two consecutive patients with TAO treated by IV glucocorticoid from 2000 to 2009 were retrospectively analyzed. They received IV methylprednisolone of 7.0 g over 18 weeks. Before and after treatment, patients underwent orbital CT for assessment of proptosis and extraocular muscle hypertrophy, and physical examination for clinical activity score (CAS). Results: Thirteen patients (31%) showed improvement in proptosis after therapy. High extraocular muscle diameter index was an independent predictor for improvement in proptosis (odds ratio=1.25, p=0.03). Smoking, age, gender and initial CAS did not predict improvement. Seven of 16 patients with initial CAS<3 (43%) and 13 of 17 with initial CAS≥3 (77%) showed improvement in diplopia after treatment (p=0.002). Of patients with CAS≥3, patients with intermittent,inconstant and constant diplopia showed improvement in diplopia in 100%, 80% and 63%, respectively. Of patients with CAS<3, patients showed improvement in 80%, 33% and 20%, respectively. Conclusion: Presence of extraocular muscle hypertrophy was the only factor predicting improvement in proptosis after IV glucocorticoid therapy. In patients with TAO, IV glucocorticoid therapy could be considered to improve proptosis when they present with increased extraocular muscle diameter, or to improve diplopia especially when they also have high initial CAS.
( Ji Hye Je ),( Ji Hoon Kim ),( Yang Jae Yoo ),( Sung Hee Kang ),( Hae Rim Kim ),( Sang Jun Suh ),( Young Kul Jung ),( Yeon Seok Seo ),( Hyung Joon Yim ),( Jong Eun Yeon ),( Kwan Soo Byun ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Several staging systems for hepatocellular carcinoma (HCC) have been purposed but there is no worldwide consensus which staging system is best. We identifi ed the best staging system evaluating the predictive ability for outcome in patients with hepatocellular carcinoma in Korea. Methods: Between January 2004 and December 2009, total of 875 patients with HCC who were diagnosed and treated at the Korea University Guro hospital were enrolled. They were followed up till April 2014. All patients were classifi ed by modifi ed UICC, Barcelona-Clinic Liver Cancer (BCLC), Cancer of the Liver Italian Program (CLIP), Chinese University Prognostic Index (CUPI), Japan Integrated Staging (JIS), Tokyo score. The demographic data, clinical variables, tumor characters, residual liver function and initial treatment modalities were reviewed. The discriminatory ability of staging system was quantifi ed using C-index. And the homogeneity and monotonicity of staging system was assessed using likelihood ratio χ2 test correlated with a Cox`s regression model neutralized by Akaike information criterion (AIC). Results: 654 (74. 7%) patients died and the median survival time was 25 months. The 5-years survival was 28. 1%. There were significant differences between all stage in modifi ed UICC, BCLC, CLIP, CUPI, JIS, Tokyo score. In the overall group of patients, CLIP stage had higher discrimination ability (C-index 0. 76) and the best monotonicity of gradient and homogeneity ability (LR χ2 test : 319. 541, P < 0. 008, AIC : 7789. 566). Also JIS system had higher discrimination ability (C-index 0. 75) and higher monotonicity of gradient and homogeneity ability (LR χ2 test : 320. 356, P<. 0001, AIC : 7792. 751). Conclusions: The CLIP and JIS stage systems showed the best prognostic stratifi cation in HCC patients of Korea.
Yim, Ji-Hye,Yun, Jung Mi,Kim, Ji Young,Lee, In Kyung,Nam, Seon Young,Kim, Cha Soon JAPAN RADIATION RESEACH SOCIETY 2017 JOURNAL OF RADIATION RESEARCH Vol.58 No.3
<P><B>Abstract</B></P><P>Ionizing radiation causes biological damage that leads to severe health effects. However, the effects and subsequent health implications caused by exposure to low-dose radiation are unclear. The objective of this study was to determine phosphoprotein profiles in normal human fibroblast cell lines in response to low-dose and high-dose γ-radiation. We examined the cellular response in MRC-5 cells 0.5 h after exposure to 0.05 or 2 Gy. Using 1318 antibodies by antibody array, we observed ≥1.3-fold increases in a number of identified phosphoproteins in cells subjected to low-dose (0.05 Gy) and high-dose (2 Gy) radiation, suggesting that both radiation levels stimulate distinct signaling pathways. Low-dose radiation induced nucleic acid–binding transcription factor activity, developmental processes, and multicellular organismal processes. By contrast, high-dose radiation stimulated apoptotic processes, cell adhesion and regulation, and cellular organization and biogenesis. We found that phospho-BTK (Tyr550) and phospho-Gab2 (Tyr643) protein levels at 0.5 h after treatment were higher in cells subjected to low-dose radiation than in cells treated with high-dose radiation. We also determined that the phosphorylation of BTK and Gab2 in response to ionizing radiation was regulated in a dose-dependent manner in MRC-5 and NHDF cells. Our study provides new insights into the biological responses to low-dose γ-radiation and identifies potential candidate markers for monitoring exposure to low-dose ionizing radiation.</P>
Doubling Time of Serum Tumor Marker in HCC Patients Predicts Recurrence after Curative Treatment
( Ji Hye Je ),( Yang Jae Yoo ),( Young-sun Lee ),( Sang Jun Suh ),( Young Kul Jung ),( Ji Hoon Kim ),( Yeon Seok Seo ),( Hyung Joon Yim ),( Jong Eun Yeon ),( Kwan Soo Byun ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: Alpha-fetoprotein (AFP) and protein-induced vitamin K absence (PIVKA-II) have been used as a marker for hepatocellular carcinoma (HCC). We aimed to investigate the correlation of doubling time (DT) of tumor markers (AFP, PIVKA-II) after curative treatment with recurrence of HCC. Methods: Between January 2005 and December 2013, total of 451 patients were enrolled. After excluding the patient with loss to follow- up, tumor remnant and absence of repeated tumor marker, 213 patients who received curative treatment were analyzed (Liver transplantation, surgical resection, radiofrequency ablation, percutaneous ethanol injection). Serum AFP and PIVKA II levels before and after the curative treatment were collected and used for analysis. Tumor marker DT was calculated as DT=t log 2/(log (marker 2nd)-log (marker 1st)) where t was the time interval between from nadir level after treatment to level at recurrence or 2 years later after treatment. Results: Mean age was 56 years. HBV infection was the most common etiology of HCC (78.4%), and most of the patients were in BCLC stage 0 and A (77.9%). During the follow up, 127 of 213 patients (59.6%) were recurred. Median DT of AFP and PIVKA-II was 20months and 18.7months. In comparing the HCC patients with or without early recurrence, DT was significantly lower in the early recurrence group (AFP and PIVKA II: 10.4 vs 26.78 months; P<0.001 and 8.75 vs 24.67 months; P<0.001, respectively). In univariate analysis, BCLC stage, tumor size, PIVKA-II level at diagnosis, AFP DT and PIVKA-II DT were significantly related to recurrence rate. In multivariate analysis, AFP DT and PIVKA-II DT and BCLC stage at diagnosis were only independent predictor of recurrence after curative treatment on HCC. Conclusions: In HCC patients with curative treatment, the DT of AFP and PIVKA-II from nadir level after the treatment is useful tools to predict early recurrence.
Yim, Ji Hye,Kim, Won Gu,Jeon, Min Ji,Han, Ji Min,Kim, Tae Yong,Yoon, Jong Ho,Hong, Suck Joon,Song, Dong Eun,Gong, Gyungyub,Shong, Young Kee,Kim, Won Bae Mary Ann Liebert 2014 Thyroid Vol.24 No.4
<P>Background: The X-linked inhibitor of apoptosis protein (XIAP) is associated with carcinogenesis, cancer progression, and metastasis through inhibition of the caspase-mediated apoptotic pathway. The BRAF(V600E) mutation is the most common genetic alteration and an established prognostic marker in papillary thyroid cancer (PTC). The prevalence of the BRAF mutation is very high and is up to 80% in Korean PTC patients. In the present study, we evaluated the potential role of XIAP expression as a novel prognostic marker to predict recurrence, in combination with the BRAF(V600E) mutational status. Methods: The study enrolled 164 patients with conventional PTC who underwent bilateral thyroidectomy followed by immediate I-131 ablation. The presence of the BRAF(V600E) mutation was evaluated by direct sequencing. The degree of XIAP expression was evaluated by immunohistochemical (IHC) staining using a monoclonal antibody. Results: The BRAF(V600E) mutation was found in 123 of 164 patients (75%) with classical PTC. XIAP expression was positive in 128 of 164 patients (75%), and positive XIAP expression was significantly associated with the presence of lateral cervical lymph node metastases (p=0.01). XIAP expression was more frequent in BRAF(V600E) mutated PTCs than in BRAF wild type PTCs (p=0.048). The BRAF(V600E) mutation was significantly associated with cancer recurrence in study subjects (hazard ratio=2.98, p=0.039). PTCs positive for the BRAF(V600E) mutation but negative for XIAP expression had a significantly higher rate of recurrent PTC (hazard ratio=4.53, p=0.012). Conclusion: The evaluation of XIAP expression and BRAF mutational analysis was more useful for the prediction of cancer recurrence in patients with PTC than BRAF genotype alone.</P>
풍속이 사과나무의 광합성 특성과 수액이동 및 엽손상에 미치는 영향
임지혜 ( Ji Hye Yim ),최영민 ( Young Min Choi ),최동근 ( Dong Geun Choi ) 한국농림기상학회 2014 한국농림기상학회지 Vol.16 No.2
This study was carried out to determine the effects of wind speed on physiological responses in ‘Fuji’ apple (Malus pumila Miller). Two levels of wind blowing (3 and 5 m·s-1) were produced by large electric fans. Photosynthetic rate was reduced by one-way wind blowing treatment at 5 m·s-1, compared to the mild wind control, and this reduction was more obvious with stronger wind and increasing duration of wind application. The reduction in photosynthesis by the wind treatments was correlated with that in the proportion of opened stomates and stomatal conductance. The one-way wind treatment at 5 m·s-1 caused a leaf browning and leaf fall, and this negative effect became more serious with increasing time of exposure to the wind treatments. The sap flux through stem increased in all wind treatments compared to the natural mild wind.