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불가사리(Asterias amurensis) 추출물을 첨가한 사료의 급이가 조피볼락 (Sebastes schlegeli)의 성장, 혈액성상 및 식세포 활성산소 생산에 미치는 효과
박희연 ( Hee Yeon Park ),임치원 ( Chi Won Lim ),김연계 ( Yeon Kye Kim ),최태진 ( Tae Jin Choi ),윤호동 ( Ho Dong Yoon ),이가정 ( Ka Jung Lee ),서연경 ( Yeon Kyung Seo ),김지영 ( Ji Yeong Kim ),박기의 ( Ki Eui Park ) 한국응용생명화학회 2007 Applied Biological Chemistry (Appl Biol Chem) Vol.50 No.4
Cho, Ha Yeon,Maeng, Seo Jin,Cho, Hyo Je,Choi, Yoon Seo,Chung, Jeong Min,Lee, Sangmin,Kim, Hoi Kyoung,Kim, Jong Hyun,Eom, Chi-Yong,Kim, Yeon-Gil,Guo, Min,Jung, Hyun Suk,Kang, Beom Sik,Kim, Sunghoon American Society for Biochemistry and Molecular Bi 2015 The Journal of biological chemistry Vol.290 No.49
<P>Many multicomponent protein complexes mediating diverse cellular processes are assembled through scaffolds with specialized protein interaction modules. The multi-tRNA synthetase complex (MSC), consisting of nine different aminoacyl-tRNA synthetases and three non-enzymatic factors (AIMP1–3), serves as a hub for many signaling pathways in addition to its role in protein synthesis. However, the assembly process and structural arrangement of the MSC components are not well understood. Here we show the heterotetrameric complex structure of the glutathione transferase (GST) domains shared among the four MSC components, methionyl-tRNA synthetase (MRS), glutaminyl-prolyl-tRNA synthetase (EPRS), AIMP2 and AIMP3. The MRS-AIMP3 and EPRS-AIMP2 using interface 1 are bridged via interface 2 of AIMP3 and EPRS to generate a unique linear complex of MRS-AIMP3:EPRS-AIMP2 at the molar ratio of (1:1):(1:1). Interestingly, the affinity at interface 2 of AIMP3:EPRS can be varied depending on the occupancy of interface 1, suggesting the dynamic nature of the linear GST tetramer. The four components are optimally arranged for maximal accommodation of additional domains and proteins. These characteristics suggest the GST tetramer as a unique and dynamic structural platform from which the MSC components are assembled. Considering prevalence of the GST-like domains, this tetramer can also provide a tool for the communication of the MSC with other GST-containing cellular factors.</P>
( Chi-son Chang ),( Jin Ha Kim ),( Jee Youn Hong ),( Seo-yeon Kim ),( Ji-hee Sung ),( Suk-joo Choi ),( Soo-young Oh ),( Cheong-rae Roh ) 대한산부인과학회 2020 대한산부인과학회 학술대회 Vol.106 No.-
Objective: Although the use of broad-spectrum antibiotics in women with preterm premature rupture of membranes (PPROM) is recommended, the optimal duration of antibiotic use is unclear. Recent studies indicated that prolonged antibiotic exposure in very low birth weight neonates was associated with increased risk of bronchopulmonary dysplasia (BPD). However, the impact of duration of prenatal antibiotics exposure is rarely explored. The objective of this study was to investigate the effect of duration of antibiotic use in PPROM and compare the incidence of BPD. Methods: This retrospective study included 402 singleton pregnancies who were admitted to the high risk care unit of our institution due to PPROM between 20+0 and 33+6 week of gestation. We allocated the study population into three groups according to duration of antibiotic use; 7 days (group 1, n=259), 8-14 days (group 2, n=70), ≥ 15 days (group 3, n=73). The maternal baseline characteristics, delivery, and neonatal outcomes were compared among three groups. BPD was defined as a condition requiring oxygen for at least 28 days after birth, and severe BPD was defined as a condition requiring more than 30% oxygen and/or positive pressure at 36 week postmenstrual age or discharge, whichever comes first. Results: The gestational age at admission was lower in groups that used antibiotics longer (p < 0.001). The gestational age at delivery and birthweight showed no significant difference among three groups. Overall, the incidence of BPD and severe BPD was higher in groups that used antibiotics longer (BPD, 19.4% (48/247) in group 1 vs. 32.4% (22/68) in group 2 vs. 30.0% (21/70) in group 3, p = 0.023; severe BPD, 5.7% (14/247) in group 1 vs. 13.2% (9/68) in group 2 vs. 15.7% (11/70) in group 3, p = 0.004, by linear by linear association). Multivariate analysis also demonstrated that severe BPD showed incremental incidence according to longer duration of antibiotic use after adjustment for cofounders including gestational age at admission and delivery (OR [95% confidence interval], 2.17 [0.76-6.21] in group 2, 5.23 [1.45-18.89] in group 3 compared to group 1 as a reference). Conclusion: Our data demonstrated that longer antibiotic use (≥ 15 days) in PPROM was associated with higher risk for severe BPD.
( Chi-son Chang ),( Yunsun Choi ),( Seo-yeon Kim ),( Cheonga Yee ),( Mina Kim ),( Ji-hee Sung ),( Sanghoon Lee ),( Suk-joo Choi ),( Soo-young Oh ),( Jeong-meen Seo ),( Cheong-rae Roh ) 대한산부인과학회 2021 Obstetrics & Gynecology Science Vol.64 No.1
Objective We investigated prenatal sonographic characteristics of esophageal atresia (EA) with advancing gestation. We focused on the degree of polyhydramnios and the stomach shape. Methods This study included 27 EA cases (EA group) and 81 idiopathic polyhydramnios cases (non-EA group). The non-EA group consisted of cases without any fetal structural anomaly, musculoskeletal disorder, chromosomal abnormality, or maternal diabetes. Both groups included only singleton pregnancies. Amniotic fluid index (AFI) and width/length (W/L) ratio as well as the product of width and length (W×L) of stomach were serially assessed during gestation and compared between the 2 groups. To predict EA using W/L ratio and W×L, receiver operating characteristic curve analysis was performed. Results Polyhydramnios was evident in 77.8% of EA cases. We observed 25.9% and 22.2% EA cases with an absent stomach and a small visible stomach, respectively. After 28 weeks, the EA group manifested significantly higher AFI than the non-EA group. After 32 weeks, W/L ratio in the EA group tended to be lower than that in the non-EA group (32-36 weeks: 1.36 vs. 1.72, P=0.092; >36 weeks: 1.43 vs. 1.63, P=0.024). To predict EA, the calculated area under the curve for W/L ratio was 0.651 after 32 weeks. The diagnosis of EA using a cut-off value of W/L ratio <1.376 showed sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio to be 84.6%, 52.9%, 1.796, and 0.081, respectively. Conclusion A low W/L ratio of stomach after 32 weeks with progressive idiopathic polyhydramnios may be used to predict EA.