에탄올에 중독된 흰쥐의 학습능력에 미치는 지구자의 효과

임종필,최훈,송정모 韓國藥用作物學會 2003 한국약용작물학회지 Vol.11 No.3

지구자 물 추출물이 에탄올 중독된 흰쥐의 학습능력에 미치는 영향을 실험하기 위하여 정상군(normal), 25% 에탄올 투여군(control) 및 지구자 물 추출물과 에탄올을 함께 투여한 검액투여군(sample)으로 나누어 10일간 각 약물을 투여한 후 11일째 1일 3회 직선수로 실험을 시행하고, 다음날부터 3일간 1일 3회씩 실험한 T-미로실험을 시행한 결과, normal군은 직선 수로실험과 T-미로실험에서 학습에 의하여 목표점 도달 소요시간이 유의성 있게 단축되고, control군은 기억력쇠퇴로 인하여 학습능력이 현저히 감소하나, 지구자의 물 추출물을 계속적으로 투여한 sample군의 경우 에탄올 중독으로 저하된 학습 능력에 유의성 있는 회복을 나타냈다. To investigate effect of fruits of Hovenia dulcis Thunb. on learning ability of ethanol-induced rats, we divided rats into 3 groups; normal, control and sample groups. Control group administered ethanol at a dose 3 g/kg bw. (25 v/v %), while sample group administered the water extract of fruits of Hovenia dulcis Thunb. 30 min. before treating same dose of ethanol as control group orally. All groups were subjected to trials of straight channel on the 1st day and to those of multiple T-maze during the following 3 days. The time required in normal group for the straight channel of the 2nd and the 3rd trials was significantly shorter than that of the 1st, while control group showed no significance. In the time required for the multiple T-maze trials of control group, there were no significance. But in the straight channel or multiple T-maze trials, the sample group showed significant decrease in the time required against control group, and also showed significant decrease in the number of selecting errors.

半夏瀉心湯과 Cimetidine의 병용투여가 흰쥐의 위궤양에 미치는 영향

林鍾弼,卜鎭尤 又石大學校 1988 論文集 Vol.10 No.-

Banhasasim-tang, chinese medicine, has been used for the treatment of the gastric ulcer and cimetidine, H_2-receptor blocker, has been also used as the gastric ulcer remedy. Therefore the concurrent administration of these two drugs may increase antiulcer activities more than administrating one by one. In order to investigate antiulcer activities, some experiments were conducted. The results obtained were as follows; 1.The concurrent administration of Banhasasim-tang and cimetidine given intraperitoneally (cimetidine 50㎎/㎏+extract 300㎎/㎏ and 50㎎/㎏+500㎎/㎏), significantly inhibited Shay ulceration in rats (12 hr ligation). 2.Aspirin ulcers induced by the administration of aspirin 200㎎/㎏(p.o) to pylorus-ligated rats were inhibited by the concurrent administration of Banhassasim-tang and cimetidine. The combination of these two drugs (cimetidine 50㎎/㎏+extract 100㎎/㎏, 50㎎/㎏+300㎎/㎏ and 50㎎/㎏+500㎎/㎏) resulted in a potentiated effect on the inhibition of the ulceration. 3.Indomethacin ulcers induced by intraperitoneal injection of indomethacin 20㎎/㎏ were inhibited by the concurrent administration of Banhasasim-tang and cimetidine. The combination of these two drugs (cimetidine 50㎎/㎏+extract 100㎎/㎏. 50㎎/㎏+300㎎/㎏ and 50㎎/㎏) resulted in a potentiated effect on the inhibition of the ulceration. 4.The antiulcer actions by the concurrent administration of Banhansasim-tang and cimetidine against Indomethacin ulcers were more effective than those against Aspirin ulcers or shay ulcers.

HPLC를 利用한 참기름中에 僞和된 들기름의 定量에 관한 硏究

林種弼,裵相淳 又石大學校 1989 論文集 Vol.11 No.-

The rapid separation of the natural triglycerides by acyl chain length and degree of unsaturation was investigated by performance liquid chromatography(HPLC). HPLC procedure was presented for quantitative determination of adulteration of sesame oil with perilla oil. The triglycerides were separated from each oil by thin layer chromatography(TLC), and fractionated into several groups on the basis of their partition numbers(PN) by reverse phase HPLC on a column packed with μ-Bondapak C_18 using chloroform and 2-propanol-acetone-methanol-acetonitrile (1+2+3+4) mixtures as a solvent. The HPLC chromatogram of pure sesame oil was composed of PN42, 44, 46, 48 and 50. Meanwhile, that of pure perilla oil was composed of PN36, 38, 40, 42 and 44. The PN42/44 peak height ratios of pure sesame oil were in the range of 0.457∼0.571. Meanwhile, those of pure perilla oil were in the range of 1.714∼1.896. A linear calibration curve is prepared by chromatographing known mixtures of the two oils and plotting the volume percent of sesame oil against the peak height ratio of a selected pair of peaks (PN 42/44).

芍藥甘草湯의 藥效比較 硏究

林鍾弼 又石大學校 1984 論文集 Vol.6 No.-

Pharmacological studies have been carried out to investigate the clinical efficacy of "Jagyag-gamcho-Tang" (JGT) comparing effects with those of "Jagyag-Tang"(JT), "Gamcho Tang"(GT) and some medicinal substances. JGT group showed more suppressive action on convulsion due to myelic and cerebrocortical causes than JT group or HT group, but on convulsion due to diencephalic causes JT group is most suppressive. JGT group showed nearly the same effect as aminopyrine on the analgesic action On the sedative action JGT group is most effective but not so effective as chloropromazine group. Hexobarbital sodium-induced sleeping time was prolonged significantly in JGT group in mice.

납 中毒된 흰쥐의 肝 代謝에 미치는 補中益氣湯의 影響

임종필,서은실 우석대학교 의약품개발연구소 1996 藥學硏究誌 Vol.1 No.-

Lead acetate and Bojungiki-tang(BIT) extract, a herbal restorative were treated p.o. 40mg/kg and 500mg/kg respectively and concurrently. and examined efects of metabolic enzymes of rats. The results obtained in this study are as follows: 1. The value of protein concentration in lead-poisoned group showed significant increse while the group of concurrent administration with BIT whowed slight decrease. 2. The value of aniline hydroxylase activities in lead-poisoned group showed 32.37% of increse while the group of concurrent administration with BIT showed 3.91% at 4th week. 3. The value of TBA-value in lead-poisoned group showed 66.7% of incresed while the group of concurrent adiministration with BIT whowed 7.72% at 4th week. 4. The value of glucose-60phosphate activities in lead-poisoned group showed a little decrease. These results on the whole indicated that concurrent administration with BIT showed significant recovery from the toxicity in lead-treated group.

담즙 역류성 위염에서의 Helicobacter pylori 감염과 조직학적 소견

임종필,양종인,최기돈,김병관,김주성,이국래,이동호,장미수,정현채,송인성 대한소화기내시경학회 2003 Clinical Endoscopy Vol.26 No.1

Backgroud/Aims: The role of Helicobacter pylori in bile reflux gastritis (BRG) is uncertain. We show the role of H. pylori and pathology in BRG. Methods: Thirty seven patients, including 5 patients who had undergone subtotal gastrectomy, were diagnosed with BRG by gastroscopic findings of bile-stained mucosa with hyperemia/ erosions. We measured total bile acid (TBA) concentration and compared the H. pylori positivity between BRG patients and 70 non-BRG patients. We showed how often we could see the pathologic findings of reactive gastritis in BRG and compared the grade of lymphoplasma cell and neutrophil infiltration between H. pylori positive and negative group in BRG. Results: TBA concentration of 10 patients was 7,376.7 5,482.6μmol/L. H. pylori positive rate of BRG was 45.9% and that of non-BRG was 70% (p=0.015). The gastric pit elongation and tortuosity were found only in 3 cases with gastric surgery. The grade of lymphoplasma cell and neutrophil infiltration was 2.41 0.51 and 1.88 0.86 in H. pylori positive BRG and 1.55 0.69 and 0.55 0.76 in H. pylori negative BRG, respectively (p<0.001). Conclusions: H. pylori infection in BRG was lower than that in non-BRG. The gastric pit elongation and tortuosity of BRG were not seen often. The lymphoplasma cell and neutrophil infiltration were relatively sparse in H. pylori negative BRG. (Korean J Gastrointest Endosc 2003;26:8-14) 목적: 담즙 역류성 위염은 반응성 위염의 한 종류로, 내시경 검사에서 위 내에 담즙이 고여있거나 점막에 염색되어 있으면서, 점막의 발적, 미란, 취약성이 관찰된다. 조직학적으로 위소와의 과증식, 모세혈관의 확장, 경미한 급만성 염증 세포의 침윤 등의 특징을 나타낸다. 많은 연구에서 담즙 역류성 위염과 Helicobacter pylori (H. pylori) 감염의 관계에 대해서 다양한 결과를 보고하고 있다. 이에 저자들은 담즙 역류성 위염 환자에서의 H. pylori의 감염률, 조직학적 변화 및 역할에 대해서 알아보고자 하였다. 대상 및 방법: 위장 증상을 호소하여 시행한 상부 위장관 내시경 검사에서 담즙 역류성 위염으로 진단받은 37명을 대상으로 하였으며, 이 중에는 위암으로 위아전절제술을 받은 5명을 포함하였다. 담즙 역류가 없는 만성 위염 환자 70명을 대조군으로 하였다. 상부 위장관 내시경 검사를 통해 10명의 환자에서 위액을 흡인하여 총 담즙산 농도를 측정하였다. H. pylori의 감염은 조직검사 및 신속 요소분해효소 검사를 시행하여 확인하였고, 환자군과 대조군의 감염 양성률을 비교하였다. 환자군에서는 위소와의 과증식, 위선의 위축, 장형화생, 위소와의 연장과 구부러짐(gastric pit elongation and tortuosity)의 빈도를 평가하였고, H. pylori 감염 양성군과 음성군 간의 호중구와 림프형질 세포의 침윤 정도를 비교하였다. 결과: 10명의 담즙 역류성 위염 환자에서 측정한 위액 내의 총 담즙산 농도는 7,376.7±5,482.6 μmol/L이었다. 환자군의 H. pylori 감염 양성률은 45.9%였고 대조군의 H. pylori 감염 양성률은 70%이었다(p=0.015). 위소와의 연장과 구부러짐은 3예(8.1%)에서 관찰되었으며 위아전절제술을 받은 환자들에서만 관찰되었다. H. pylori 감염 양성군의 림프형질 세포의 침윤 정도는 2.41±0.51로 H. pylori 감염 음성군의 1.55±0.69보다 높았다(p<0.001). H. pylori 감염 양성군의 호중구의 침윤 정도는 1.88±0.86으로 H. pylori 감염 음성군의 0.55±0.76보다 높았다(p<0.001). 결론: 담즙 역류성 위염 환자에서의 H. pylori의 감염률은 담즙 역류가 동반되지 않은 위염 환자보다 낮았다. 담즙 역류성 위염의 특이적인 조직학적 소견인 위소와의 연장과 구부러짐은 흔하게 관찰되지 않았다. 호중구와 림프형질 세포의 침윤은 H. pylori 감염 양성군이 감염 음성군보다 많았다.

태충혈(太衝穴)에 대(對)한 문헌적(文獻的) 고찰(考察)

임종필,성낙기,Im, Jong-Pil,Seong, Nak-Gi 대전대학교 한의학연구소 1995 한의학연구소 논문집 Vol.4 No.1

대장암 검진, 언제부터 어떻게 얼마나 자주 해야 하나?

임종필 대한내과학회 2018 대한내과학회 춘계학술대회 Vol.2018 No.-

Transformer-Reuse Reconfigurable Synchronous Boost Converter with 20 mV MPPT-Input, 88% Efficiency and 37 mW Maximum Output Power

임종필,문승언,여준기 한국전자통신연구원 2016 ETRI Journal Vol.38 No.4

This paper presents a transformer-based reconfigurable synchronous boost converter. The lowest maximum power point tracking (MPPT)-input voltage and peak efficiency of the proposed boost converter, 20 mV and 88%, respectively, were achieved using a reconfigurable synchronous structure, static power loss minimization design, and efficiency boost mode change (EBMC) method. The proposed reconfigurable synchronous structure for high efficiency enables both a transformer-based self-startup mode (TSM) and an inductor-based MPPT mode (IMM) with a power PMOS switch instead of a diode. In addition, a static power loss minimization design, which was developed to reduce the leakage current of the native switch and quiescent current of the control blocks, enables a low input operation voltage. Furthermore, the proposed EBMC method is able to change the TSM into IMM with no additional time or energy loss. A prototype chip was implemented using a 0.18-μm CMOS process, and operates within an input voltage range of 9 mV to 1 V, and an output voltage range of 1 V to 3.3 V, and provides a maximum output power of 37 mW.

PS/PMMA 블렌드의 유변학적 성질과 Morphology와의 관계

임종필,한민수,정현철,김우년 한국고분자학회 2000 한국고분자학회 학술대회 연구논문 초록집 Vol.2000 No.4