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Allene 화합물의 Pinacol Rearragemment에 관한 연구
임중기,함원훈,이미정,양재권,김기수 성균관대학교 약학연구소 1991 成均藥硏論文集 Vol.3 No.1
Abstracts-A effective and new approach to development of impressive methodology for the synthesis of carbocyclic ring system was investigated. It is sequential cationic cycliazationpinacol rearrangement of acetal-allenic derivatives. In order to investigate the acid-catalyzed rearrangement, aldehyde and ketone derivatives with acetal as electrophile were first prepared. And the allenes were synthesized by Yamamoto procedure. Carvocyclic rings were formed by cyclization-pinacol rearrangement from allenes under Lewis acid in pressence of excess trimethylsily trifluoromethane sulfonate.
林中基,趙台淳,李善美 成均館大學校 1982 論文集 Vol.32 No.-
To elucidate the pharmacological actions of Ponicir, the effects of the fluid extract on isolated guinea pig ileum, blood vessel permeability in mice, granuloma formation in rats and swelling of rat hind paw were examined. The histamine induced contraction of isolated ileum was significantly blocked by Ponicir fluid extract and the blood vessel permeability was also significantly inhibited. In the experiments on granuloma formation only the exudate formation was inhibited. Forthermore, swelling of hind paw induced by 1% carageenin was also significantly inhibited by Ponicir fluid extract.
임중기,이강노 성균관대학교 약학연구소 1991 成均藥硏論文集 Vol.3 No.1
Abstract-Ulcers are believed to result from an imbalance between the aggressive (acid, pepsin) and defensive forces (bicarbonate, mucous) in the stomach and duodenum. This imbalance can be restored by reducing the secretion of acid from gastric parietal cells. These mechanisms include inhibition of acid secretion by histamine H_2-receptor antagonists, H^+/K^+-ATPase (proton pump) inhibitors, anticholinergics, gastrin antagonists and prostaglandins. However, anticholinergics and prostaglandins were not selective in the action and side effects limited their clinical application. Therefore, most effective therapies are generally histamine H_2-antagonists and H^+/K^+-ATPase inhibitors. Here, these two groups are medicinal chemically reviewed.
Epinephrine 이 흰쥐의 血淸, 肝 및 筋肉內 Lactate Dehydrogenase에 미치는 影響
林中基,金雲將 成均館大學校 1975 論文集 Vol.20 No.-
1. A series of experiment has been conducted in the state of hyperglycemia caused by the continuously subcutaneous injection of epinephrine into previously fasted albino rats, and then the variation of LDH activities and LDH isozyme patterns in serum, liver and muscle have been studied. 2. The LDH-activity has been elevated in serum and liver above the average level for control group, but little change found in muscle. 3. The change of LDH isozyme patterns has been shown that in serum LDH_1 and LDH_5 are increased, and in liver LDH is tend to increase, while in muscle LDH_1 increased and LDH_5 decreased.
林中基,李漢九,元正喜 成均館大學校 1981 論文集 Vol.29 No.-
4-Acetaminosalicyldialkylamidc was synthesized by amidation of N.O.-diacetyl-4-aminosalicyl chloride with N.N.-dimethylamine or N.N-diethylamine. 2-Alkoxy-4-acetaminodialkyl-benzamide was synthesized by alkylation of 4-acetamino-salicyl dialkylamide with alkyl halides or dimethyl sulfate.
Piperine 유도체 〔3-(3',4'-dihydroxyphenyl)-2-propenic acid amide〕의 합성에 관한 연구
林中基,咸元勳,김진영 성균관대학교 약학연구소 1990 成均藥硏論文集 Vol.2 No.1
Abstract-3,4-Methylenedioxyphenyl cinnamic acid was synthesized from the reaction of 3,4-methylenedioxy benzaldehyde with malonic acid, via Perkin reaction and it was added to SOCI_2. From acid chloride, many amide derivatives were synthesized, using various amines. In the final step, cleavage of 3,4-methylenedioxy group was not accomplished by the traditional method of halogenation with phosphorous pentachloride. And, protection of the OH-group of catechol with tosyl, acyl, methoxy methyl chloride or acetonide was failed. So, aryl benzyl ethers were prepared from a protocatechualdehyde by treating an alkaline solution of the protocatechualdehyde with a benzyl chloride. Amide derivatives were synthesized from the former ways. Benzyl group was readily removed by hydrogenolysis.
5-(3,4-Dihydroxyphenyl)-2,4-pentadienoic acid amide 유도체의 합성에 관한 연구
林中基,尹汝文 성균관대학교 약학연구소 1989 成均藥硏論文集 Vol.1 No.1
Abstract-Seven 5-(3,4-dihydroxyphenyl)-2,4-pentadienoic acid amides ① 5-(3,4-dihydroxyphenyl)-2,4-pentadienoyl anilide ② 5-(3,4-dihydroxyphenyl)-2,4-pentadienoyl-2,6-dimethyl piperidide ③ 5-(3,4-dihydroxyphenyl)-2,4-pentadienoyl-3-methyl piperidide ④ 5-(3,4-dihydroxyphenyl)-2,4-pentadienoyl nitroanilide ⑤ 5-(3,4-dihydroxyphenyl)-2,4-pentadienoyl dimethylamide ⑥ 5-(3,4-dihydroxyphenyl)-2,4-pentadienoyl monoethyl amide ⑦ 5-(3,4-dihydroxyphenyl)-2,4-pentadienoyl diethyl amide were synthesized for searching new anticonvulsants. The amdies could be synthesized by Perkin reaction of 3,4-diacetoxybenzaldehyde with crotonic acid amides in the presence of sodium amide and then by hydroylsis of 3,4 diacetoxy group.