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장주기파에 의한 호안 및 방파제간의 파랑-구조물 상호작용
이홍식,김성덕 中央大學校 建設環境硏究所 2002 環境科學硏究 Vol.13 No.2
입사주기, 호안 반사율, 및 방파제의 길이의 변화에 따라 방파제와 호안사이에 발생하는 파랑-구조물의 상호작용을 이론적으로 조사하였다. 회절이론을 기초로 하여 경계적분방정식을 유도하였고, 경계요소법에 의해 수치계산을 실시하였다. 수심은 일정한 것으로 가정하고, 두 종류의 반사율과 8가지의 입사주기 경우에 대하여 조사하였다. 입사주기의 변화 및 반사율의 변화에 의해 파고분포의 형태가 일반형, Peak형, Surge형태의 파형으로 변화되는 것이 나타났다. The wave-structure interactions have been studied theoretically by varying with the incident wave period and the reflection ratio. The method is based upon the linear diffraction theory obtained by a pair of boundary integral equations, and the water depth is assumed to be constant. A number of the simulation has been performed to predict the wave interaction. As the results, the various profiles of surface wave have been observed in accordance with the conditions of incident wave period and reflection ratios.
Quetiapine의 정신분열증에 대한 효능 및 안전성에 관한 개방 연구
이홍식,강대엽,송동호,김영신,전덕인,김세주,김유석,안석균 대한정신약물학회 2004 대한정신약물학회지 Vol.15 No.1
Objective: The efficacy, tolerability and safety of quetiapine in schizophrenia patients diagnosed by the diagnostic criteria of schizophrenia of the Diagnostic Statistical Manual 4th edition(APA) was studied in psychiatric department of 4 hospital in Korea. Methods: Sixty-four patients (male 31, female 33; age 34.2±10.4 years; illness duration 8.1±8.3 years) who showed acute exacerbation, partial response, or intolerable adverse event to previous antipsychotic drugs were recruited. Doses of quetiapine were adjusted to maximize efficacy and minimize adverse events. Efficacy was assessed by the Brief Psychiatric Rating Scale (BPRS) and Clinical Global Impression (CGI) scale. Tolerability and safety were assessed by reports of adverse events, clinically significant abnormal laboratory values and changes from the baseline to week 8 in the Abnormal Involuntary Movement Scale (AIMS) and Simpson-Angus total score as index of extrapyramidal symptoms (EPS). Results: Fifty-three patients completed the 8 weeks trial. The clinical symptoms indexed by BPRS were significantly improved(baseline score = 37.9±13.0, score at the end = 24.3±13.6; F = 41.5, d.f. = 2.4, p = 0.000). The CGI score of severity of illness was also significantly reduced (baseline score = 4.7±1.1, score at the end = 3.6±1.2; F = 27.6, d.f. = 2.2, p = 0.000). The frequencies of the worsening of AIMS and Simpson-Angus scores at the end of study were 7.5% and 4.2%, respectively. The most common adverse events of at least moderate intensity were EPS(9.3%), constipation(6.3%), and sedation(4.7%). Conclusions: The results of this study suggest that quetiapine is effective, may have a favorable EPS, and has overall safe tolerability in the patients with schizophrenia, and schizophreniform disorder.
정신의학적 증상을 수반한 Klinefelter 증후군 1예
박정주,허갑범,이홍식 大韓神經精神醫學會 1984 신경정신의학 Vol.23 No.4
The recent studies on Klinefelter's syndrome, which was first described by Klinefelter, et al. in 1942, revealed that intellectual impairment and neuropsychiatric disorders were combined in many cases of Klinefelter's syndrome. The authors present a 15 year old male patient with confirmed diagnosis of Klinefelter's syndrome, who showed various secondary psychiatric manifestations such as severe depression, anxiety, self and sexual identity confusion, various psychosomatic symptoms and adjustment problems with poor interpersonal relationship. The variety of psychiatric manifestations accompanying Klinefester's syndrome are reviewed from the literature. Comprehensive psychiatric evaluation and treatment via consultation-liaison psychiatry is strongly recommended for klinefelter's syndrome with psychiatric manifestations.
이홍식 근역한문학회 2012 한문학논집(漢文學論集) Vol.34 No.-
This paper aims at bringing the will existing outside of Chinese classics study over to inside of that study. Although wills are clearly literature arising from material, death, they stayed at outside Chinese classics until a recent day. It is not they fall literary value but they are not interested from reachers. So this paper reveals that wills are attractive literary fares linking literary tradition, they will be studied by many reachers. For which, this paper bounce around three points. The first, it classifies formal features on wills, kinds of magazines, containing same system with epistolary wills. The second, it researches contents of will and their aesthetic features. The last, how wills are accepted and understood by people in the days and the later days. Through study of these three study field, wills enough derive literary movement by the media of affection between the live and the dead, they are enjoyed as literary fares. The studies on wills start now. These studies can be done in various fields such as education, history, society, culture and so on. It is very interesting that comparative study with Korean wills. I hope that the studies related with wills shall hot up in the future. 본고는 그 동안 한문학 연구의 영역 바깥에 놓여 있었던 유서를 연구 영역으로 끌어들이기 위해 기획되었다. 유서는 죽음을 매개로 탄생한 문학임에 분명하지만, 최근까지 한문학 연구에서 변방에 머물러 있었다. 작품의 문학성이 떨어져서라기보다는 연구자들의 관심 부족에 기인한 바가 크다. 이에 본고에서는 유서가 죽음의 문학적 전통을 잇고 있는 매력적인 문예물임을 밝혀 향후 다양한 연구의 물꼬를 털 수 있게 하고자 하였고, 이를 위해 다음 세 가지에 중점을 두고 논의를 진행하였다. 우선 서간체 유서와 그와 동일한 체재를 유지하고 있는 잡저류 유서의 형식적 특징을 일별하였고, 두 번째로는 유서의 내용과 그것이 만들어 내는 미적 특징에 대해 천착하였으며, 마지막으로는 유서가 당대 혹은 후대에 어떻게 수용되고 향유되었는지를 살폈다. 이 세 영역에 대한 탐구를 통해 유서가 산 자와 죽은 자 사이에 놓여 있는 정을 매개로 문학적 감동을 충분히 이끌어내고, 문예물로서 향유되었음을 확인할 수 있었다. 유서에 대한 연구는 이제 시작이다. 교육, 역사, 사회, 문화 등 다양한 영역에서의 연구가 가능할 것으로 예상되며, 한글유서와의 비교 연구 또한 굉장히 매력적일 것이라 판단된다. 앞으로 유서 관련 연구가 활발해 질 수 있기를 희망해본다.