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삼황세제 가미방 외용이 NC/Nga 마우스의 아토피 피부염에 대한 효과
황충연,박민철,홍석훈,주현아,조현우,정수영,조정희,Hwang, Chung-Yeon,Park, Min-Cheol,Hong, Seok-Hoon,Joo, Hyun-A,Cho, Hyun-Woo,Jung, Soo-Young,Cho, Jeong-Hee 대한한방안이비인후피부과학회 2012 한방안이비인후피부과학회지 Vol.25 No.1
Objectives : In this study, Samhwangsaejaegami extract was tested to prove its anti-atopic dermatitis effect on NC/Nga mice. Methods : In order to evaluate the external use effects of Samhwangsaejae extract on anti-atopic dermatitis, the expression of filaggrin, serine palmitoyltransferase(SPT), and COX-2 were analyzed. In vivo study, clinical skin severity score, IgE, IL-4, IL-5 and IL-6 level were analyzed through NC/Nga atopic mice model after 12 weeks external treatment. Results : In vitro study results showed the reduction in the expression of filaggrin, SPT, and COX-2. In vivo study results demonstrated the significant reduction in clinical skin severity score, IgE, IL-4, IL-5, IL-6 expression level. Conclusions : These results showed Samhwangsaejaegami extract can be a promising candidate for anti-atopic dermatitis treatment.
이명(耳鳴)의 동(東)·서의학적(西醫學的) 문헌(文獻) 고찰(考察)
허은선,황충연,Heo, Eun-Sun,Hwang, Chung-Yeon 대한한방안이비인후피부과학회 2016 한방안이비인후피부과학회지 Vol.29 No.4
Objectives : This study is performed to investigate the therapy on tinnitus through the literature of Eastern and Western medicine. Methods : This study review the definition, etiology, classification, internal and external methods of treatment of tinnitus based on 50 articles of Eastern medicine, 16 articles of Western medicine about the treatment of tinnitus. Results : The results were as follows. 1. In Eastern medicine, the cause and mechanism of disease of tinnitus arose from the state of qi-blood deficiency, internal dampness-heat and depression stagnation. In Western medicine, there are mainly caused by damage to the auditory system the lower induced changes in the upper. 2. In Eastern medicine, differentiation of syndromes classifies clinical aspects, and cause and mechanism of disease. In Western medicine, it divides into an generating region, clinical and associated symptoms aspects. 3. In Eastern medicine, internal method of treatments of tinnitus are divided into four treatments. In Western medicine, internal methods of tinnitus are vasodilators, blood-flow improvers, Metabolism improvers etc. 4. In Eastern medicine, external method of treatments of tinnitus are paste preparation method, powder preparation method, pill preparation method, acupuncture & moxibustion method. In Western medicine, external method of treatments of Tinnitus are divided into injection, other surgical therapies and adjuvant therapy. Conclusions : Until now, there is no perfect, effective single treatment. We think that Eastern medicine approach and treatment can be helpful to overcome the limitations of tinnitus cure.
탁리소독음(托裏消毒飮) 합(合) 황련해독탕(黃連解毒湯)의 아토피피부염에 대한 실험적 연구
원영호,황충연,임규상,김종한,고성규,이부균,이동효,김남권,Weon, Young-Ho,Hwang, Chung-Yeon,Lim, Kyu-Sang,Kim, Jong-Han,Ko, Seong-Gyu,Lee, Boo-Kyun,Lee, Dong-Hyo,Kim, Nam-Kwen 대한한방안이비인후피부과학회 2011 한방안이비인후피부과학회지 Vol.24 No.1
Objective : This Experimental study was done to investigate the Effect of Taklisodok-um and Hwangryunhaedok-tang(TH) on Atopic Dermatitis. Methods : We assessed effects of TH on the IgE, IL-4, IL-5, IL-6, IgM, IgG1, IFN-${\gamma}$ in vivo, on the IL-4, IL-5, CCR3 in the skin tissues of ear and dorsum with NC/Nga mice. And we assessed effects of TH on the COX-2, IL-$1{\beta}$, TNF-${\alpha}$, IL-6 with RAW 264.7 cell. Results and Conclusion : 1. IgE, IL-4, IL-5, IL-6, IgM, IgGl levels in the serum of TH treated NC/Nga mouse group were decreased compared to the untreated control mice. IFN-r showed a increase in the experimental group compared to the untreated control group. The spleen weight of TH treated NC/Nga mice was decreased compared to the untreated control group. 2. mRNA expression levels of IL-4, IL-5 and CCR3 in the skin tissues of TH treated NC/Nga mice were decreased, and expression levels of IL-6 in the skin tissues of TH treated NC/Nga mice were decreased compared to the untreated control group. IFN-${\gamma}$ mRNA expression levels were increased compared to the untreated control group. 3. Judged from that IL-$1{\beta}$, TNF-${\alpha}$, IL-6 express of gene, effect of inflammatory Cytokines revelation were decreased compared to the untreated control group. 4. Depend on the strength of TH, inflammatory RAW 264.7 in the serum of TH were inhibited compared to the untreated control serum that leaded a COX-2 activity model. 5. Histological observation of the ear and skin tissues showed that the extents of inflammation and infiltrated immune cells in the epidermis and dermis of TH treated NC/Nga mice were highly reduced compared to the untreated control group.
홍석훈,황충연,윤효진,박준영,Hong, Suk-Hoon,Hwang, Chung-Yeon,Yoon, Hyu-Jin,Park, Joon-Young 대한한방안이비인후피부과학회 2006 한방안이비인후피부과학회지 Vol.19 No.2
Meniere's disease is a syndrome with characteristic three symptoms(tinnitus, hearing loss and vertigo). The main pathology is imer lymphdropy by various causes. Western therapy consists of a dietary treatment, medication and a operation. But in these days, Meniere's disease is almost incurable. So we experienced one case of Meniere's disease treated with oriental medical treatment as like acupuncture, herbal medication etc. 37 year-old female patient had a diagnosed Meniere's disease by western medical doctor and had been treated for one year. But there has not been effective. After oriental medical Ueatment, Meniere's disease was recoverd at the end of one month.
화장품 임상시험 프로토콜 개발을 위한 체계적 문헌 고찰
조가원,황충연,홍석훈,김남권,Jo, Ga-Won,Hwang, Chung-Yeon,Hong, Seok-Hoon,Kim, Nam-Kwen 대한한방안이비인후피부과학회 2013 한방안이비인후피부과학회지 Vol.26 No.1
Objective : The aim of this review is to development of clinical trial protocol for against cosmetics as a treatment of dry skin condition. Methods : We searched the literature from 2002 through April 2012 using 5 databases. We included randomized controlled trials(RCTs) in which human participants with dry skin condition as chief complaint were treated with cosmetics. The methodological quality of all RCTs was using the Jadad score. Results : Nine RCTs met the inclusion criteria. Cosmetic types included cream (7 trials), lotion (1 trial), oil (1 trial) and body wash (1 trial). The methodological quality of the trials was generally low (Jadad score: mean 1.78; range, 1 to 3). Conclusions : The evidence for cosmetics as an effective treatment for dry skin condition(xerosis) is currently scarce and of poor quality, and is therefore inconclusive. More rigorous studies are warranted.
서은성,황충연,임규상,강형원,박민철,김남권,Seo, Eun-Sung,Hwang, Chung-Yeon,Lim, Kyu-Sang,Kang, Hyuong-Won,Park, Min-Chol,Kim, Nam-Kwen 대한한방안이비인후피부과학회 2012 한방안이비인후피부과학회지 Vol.25 No.4
Objective : This study was done to investigate the correlation between general quality of life(QOL) and disease specific QOL of tinnitus patients. Methods : 2009 National health and nutrition survey(NHNS) data were employed for analyzing the mean estimates of total population and tinnitus sub-group patients, and predicting the regression equation of mapping between EQ-5D and disease severity. Baseline statistical analyses and normality tests were done by using Student t-test, Chi-square test, Shapiro-Wilk test and ladder test. Hierarchial regression analyses were performed using related variables and predicted the optimal regression equations. Statistical significance was achieved if the probability was less than 5%. Results : Firstly, the standardized prevalence of tinnitus patient in South Korea was 18.69% and over 90th age-group was relatively higher than other groups. Mean value of domestic QOL measured by EQ-5D was estimated as 0.9486 and QOL of tinnitus subgroup(0.9169) was lower than the non-tinnitus subgroup(0.9559), significantly. Stratified by age and sex, QOLs of all sub-groups with tinnitus were lower than without tinnitus sub-groups significantly. Regression equations from 2009 NHNS data were developed using hierarchial regression analysis which is as follows. $$Y_{EQ-5D}=0.9224-0.0079{\times}T1-0.0261{\times}T2-0.0951{\times}T3+\sum_{i=1}^{n}{\beta}_i{\times}X_i\\{\hspace{95}}(0.0106){\hspace{3}}(0.0037){\hspace{30}}(0.0072){\hspace{30}}(0.0038)$$ ($X_i$=Other explanatory variables except Tinnitus QOL1, 2, 3, ${\beta}$= Regression Coefficient of Model 4) Conclusion : We confirmed the correlation among THI and EQ-5D and HUI-III, and developed the inference for regression equation of EQ-5D.
耳鍼을 活用한 禁煙鍼 施術이 吸煙靑少年들에게 미치는 影響
최수철,황충연,Choi, Soo-chul,Hwang, Chung-yeon 대한한방안이비인후피부과학회 1999 한방안이비인후피부과학회지 Vol.12 No.1
Recently WHO death from smoking-related illness would increase more than a thousand in the future. But in spite of various harms, smoking cigarette in developing countries is increasing especially in the adolescents. So in order to evaluate whether auricular acupuncture therapy is effective to quit smoking, clinical examination was carried out. And the results showed that age of starting smoking become lower. The cause of smoking is curiosity, relaxation, envy and comradeship. For this reason they want to stop smoking but feel it is difficult to do. Cigarette smoking didn't show any significant change after auricular acupuncture in both control and therapy. And physical and psychological change did not present any significance. However, auricular acupuncture therapy was appeared to be effective to stop smoking. So with these results, further systemic research to examine the effect of auricular acupuncture is seem to be necessary.
강활유풍탕(羌活愈風湯)이 뇌허혈(腦虛血)로 유도된 대뇌신경세포손상(大腦神經細胞損傷)에 미치는 영향
문병순,황충연,김경요,이건목,성강경,이대용,이성근,Mun Beong-Sun,Hwang Chung-Yeon,Kim Keong-Yo,Lee Geon-Mok,Sung Kang-Keong,Lee Dae-Yong,Lee Seoung-Geun 대한한방내과학회 2003 大韓韓方內科學會誌 Vol.24 No.1
Objective : Experimental studies have been done to elucidate the effect of kangwhalyupung-tang(KWYPT) on neuronal cell damage induced by brain ischemia. Method : The cytotoxic effect of ischemia was measured in the MTS assay cultures. MTS assay, INT assay, neurofilament(NF) enzymeimmuno assay(EIA). And the KWYPT on ischemia-induced neurotoxicity were examined by in vitro assays. Results : 1. The KWYPT protected effectively neuronal cell-death resulted from brain ischemia induced by the treatment of $95%N_2/5%CO_2$ for 10 min in those dependent fashion. 2. The KWYPT effectively increased the amount of NF resulting from brain ischemia, induced by the treatment of $95%N_2/5%CO_2$ for 15 min in those dependent fashions. Conclusions : KWYPT protects the brain ischemia-induced neurotoxicity through the increase of cell viability and of neurofilament in dose-dependent manner.