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수면 중 발생한 대퇴경부 골절로 발견된 직장 소세포암 1예
황지주,전성국,황일순,김은주,임창훈,정호연,한기옥,장학철,윤현구,한인권,문우남,홍성란 대한내과학회 2002 대한내과학회지 Vol.62 No.5
Small cell carcinoma of the colon and rectum is a rare primary epithelial malignancy at this location. Histologically, this tumor represents a spectrum of neuroendocrine differentiation. The neuroendocrine cancers of the colon manifest a highly aggressive behavior, even more than their adenocarcinoma counterpart of the same stage. Small cell carcinoma in the colon has early metastasis and the prognosis is extremely poor. We report a case of small cell carcinoma of the rectum manifesting as femur neck fracture during sleep.
G 단백질 변이를 동반한 McCune - Albright 증후군 1 예
민헌기,윤현구,한인권,장학철,임창훈,박찬문,한기옥,강영순,문인걸,홍성란,정필호,황정규,김윤이,황지주,정호연 대한내분비학회 1999 Endocrinology and metabolism Vol.14 No.4
McCune-Albright syndrome (MAS) is a sporadic disease classically including polyostotic fibrous dysplasia, cafe -au-lait spots, sexual precocity, and other hyperfunctional endocrinopathies. Recent investigations suggest an etiological role for activating embryonic somatic missense mutations in the gene for the a subunit of Gs (Gsa), the G protein that stimulates adenylyl cyclase. DNA from bone, ovary, and blood was analyzed by using polymerase chain reaction and sequenced. A embryological somatic mutation of Gsa gene encoding substitution of a Cys for Arg at amino acid 201 from cells of dysplastic bone and ovary was observed, and the distribution of mutant gene reveals mosaic pattern. We report a case of McCune-Albright syndrome with an activating mutation at codon 201 of Gsa subunit on ovary and bone tissue that was experienced recently(J Kor Soc Endocrinol 14:779-785, 1999).