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- 저자 : 황중하(Joong Hwa Hwang) (검색결과 3 건)
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답차 및 자전거 Ergometer 운동부하검사의 비교관찰
김경호(Kyung Ho Kim),황중하(Joong Hwa Hwang),이주형(Joo Hyung Lee),배현혜(Hyun Hae Bae),이호영(Ho Young Lee),김용민(Yong Min Kim),김현수(Hyeon Su Kim),이순규(Soon Gyu Lee),이병기(Byung Ki Lee),이중기(Choong Ki Lee),박희명(Hi Myung Pa 대한내과학회 1995 대한내과학회지 Vol.49 No.4
N/A Objectives: For the evaluation of cardiopulmonary endurance, treadmill (TM) and bicycle ergometer (EG) are the most commonly used modes of exercise testing, and the results obtained by these two modes are known to be different. However, it is still controversial that which parameters are how much different. The purpose of our study is to compare two modes of testing in healthy subjects. Methods: Sixty-nine healthy subjects consisting of 34 males and 35 females participated in the study. All the subjects underwent symptom-limited maximal exercise tests by both TM and EG modes at an interval of less than seven days. The TM tests were done by Bruce protocol in both genders, and in the EG tests, work load was increased by 25 watts once every minute for males and 15 watts for females. Results: The maximal heart rate, oxygen uptake and oxygen pulse (HR max, VO2 max & O2 pulse max) by the TM mode of testing were significantly greater than those by the EG mode in both genders, particularly in females. The differences in HR max were approximately 7% and 9% in males and females, respectively, whereas those in VO2 max and O2 pulse max were 11-25%. The VO2, max by TM and EG modes showed highly significant correlation. At maximal exercise, the minute ventilation was significantly different between the two modes, and VE by the TM mode was approximately 15% and 22% greater than by the EG mode in males ad females, respectively. Among variables reflecting ventilatory reserves at maximal exercise, the ratio of VE. max to maximal voluntary ventilotion (MVV) in ;he TM mode was approximately 15% and 22% greater in males and females, repectively. The breathing reserve (MVV-VE max) in the EG mode was approximately 79% and 147% greater in males and females, repectively. The results of these two variables, VE max/MVV and MUV-VE max, are explained by the more marked increase in VE max by the TM mode and denote that the ventilatory reserve capacity at maximal exercise is greater in the EG mode. Conclusion: Our study reveals that the TM mode of maximal exercise testing induces more pronounced cardiopulmonary responses than the EG mode, particularly in females. And this is well manifested by the facts that VO2 max, O2. pulse max and VE- max obtained by the TM mode of testings are 10% or more than those by the EG mode. The HR max by the TM mode was also greater than that by the EG mode in both genders, but its difference was less than 10%.
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만성신부전증 동물 모델에서 신 기능 손상과 Osteopontin의 발현 정도
김용진,김상기,현병화,이덕현,황중하 대한신장학회 2000 Kidney Research and Clinical Practice Vol.19 No.5
Tubuolointerstitial inflammation and tubular injury account for most types of glomerulonephritis. The injury is characterized by an infiltration of mononuclear cells with atrophy and dilation of tubules and increased deposition of collagen in the interstitium. Despite the fact that the degree of tubulointerstitial injury in glomerular diseases may be the best predictor of overall outcome, the pathogenic mechanism by which the tubular injury develops remains unknown. Osteopontin, a highly acidic, phosphorylated, secreted glycoprotein, is up-regulated in renal cortex in many experimental models of tubulointerstitial fibrosis. In this study, we examined the expression of osteopontin in tubulointerstitium in experimental renal failure mouse, FGS/KIST. Mice were assigned three groups and sacrificed at 1 month, 2 months, and 3 months, in each. Proteinuria, GFR, the degree of tubulointerstitial inflammation, tubular atrophy, glomerulosclerosis and osteopontin expression were measured. Three-month-old group showed severely decreased GFR and marked tubulointerstitial inflammation and glomerulosclerosis compared with other groups. The expression of osteopontin increased with the severity of tubulointerstitial injury. These data suggest that osteopontin may act as a chemotactic or adhesive factor in the recruitment of the monocyte/macrophages and have a role in the pathogenesis of the tubulointerstitial injury.
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