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황정열(Jung Yuel Hwang),심우영(Woo Yong Sim),이무형(Mu Hyoung Lee),허충림(Choong Rim Haw) 대한피부과학회 1992 대한피부과학회지 Vol.30 No.5
We present a case of malignant melanoma associated wi h itiligo in the 49 year-old female patient. Skin lesions showed that centrally located dark black nodile surrounded with brownish colored plaque on the upper half and depigmented patch on the lower half on the left upper thigh and depigmented patch on the right forehead. In western countries, patients with melanoma have been obscrved to develop vitiligo or depigmented spots on the skin, while in korea, rarely observed. We reports that malignant melanoma associated with vitiligo. (Kor J Dermatol 1992;30(5):747-751)
황정열(Jung Yuel Hwang),김낙인(Nack In Kim),허충림(Choong Rim Haw) 대한피부과학회 1993 대한피부과학회지 Vol.31 No.3
We report a case of pretibial myxedema with hypothyroidism in a 52-year-old woman. She suffered from primary hypothyroidism for a period of 17 years. She was treated with a daily dose of sodium levothyroxine 0.2 mg intermittently. She had erythematous ftesh colored, hard and thickened plaque. on the left pretibial area for onr year. The histopathologic findings showed considerable amount of muci in the upper and mid dermis. Toluidine blue and alcian blue stain demonstrated an extensive deposition of dermal mucin. We treated her with a topical steroid and oral sodium levothyrcxire. (Kor J Dermatol 1993; 31(3): 408-411)
배양된 멜라닌세포에서 UVB 일회 조사후 형태 및 증식의 변화
이승한(Sung Han Lee),황정열(Jung Yuel Hwang),이무형(Mu Hyoung Lee),박재경(Jai Kyung Park),허충림(Choong Rim Haw) 대한피부과학회 1992 대한피부과학회지 Vol.30 No.6
In humans, the major stimulus for cutaneous pigmentation is ultraviolet radiation. Little is known about the mechanism underlying this response, in part, because of the complexity of the interactions involving the whole epidermis. The present stucy was undertake to evaluate the effects of a single exposure of UVB on cultured normal melanocytes. Melanocytes were exposed to UVB from 5.1 mJ/cm to 203 mJ/cm. The results were as follows : 1. The main morphologic changes in UVB-exposed groups w re larger sized cells, more blunted dendrites, and shorter dendrites than in the control group. These cells increased sized according to the increased doses of VVB, but above 101.5 mJ/cm, the melanocytes shrunk and were destroyed. 2. From 20.3 mJ/cm of UVB, the proliferation of melanocyte was decreased, Especially, there was statistical!y significant difference above 50.8 mJ/cm (p<0.05, p<0.01). 3. The antiproliferativo effect increased with the passage of tirie after UVB exposure. So, cell count could not be done in 101.5 mJ/cm and 203 mJ/cm on the third day, and in 50.8 mJ/cm, 101.5 m J/cm and 203 mJ/cm on the seventh day. 4. Statistically the melanin content per well was significantl dicreased to 11-28% of each control group with dose above 50.8 mJ/cm (p<0.05, p<0.01). The melanin content per cell was increased to 107-128% of each control group when doses were below 20.3 mJ/cm and decreased to 49-79% of each control group when above 0.8 mJ/cm on the third day, but there was no statistically significant difference. In summary, when melarocytes were exposed to UVB, morphclogic changes progressed to cell differentiation. The results also suggested that a low or dose of UVB has an antiproliferative arid mild melanogenic effect, and a higher dose of UVB has a direct cytotoxic effect. (Kor J Dermatal 1992;30(6):802-810)
김재홍,윤기범,박평원,김영진,전경민,김영태,김중환,곽호,구상완,송민석,유옥,지혜구,김동원,문상은,박영립,정승호,성범진,성순제,엄주용,황정열,이기홍,이주협,전태진 대한화학요법학회 1994 대한화학요법학회지 Vol.12 No.1
The prevalence of PPNG among pretreated gonorrhea cases isolated at the STD clinic of Choong-Ku Public Health Center in Seoul has been studied and reported annually since 1981. In 1991, 123 strains of N.gonorrhoeae were isolated, among which 58(47.1%) were PPNG. In 1992, 98 starains of N.gonorrhoeae were isolated, among which 51(52.0%) were PPNG. In all, 109(49.3%) strains were found to be PPNG among 221 strains isolated between 1991-1992. The prevalence of PPNG in Seoul showed increased tendency till 1989, thereafter, it has been stationary or slightly decreasing.