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한국인 정신분열병 환자에서 Apolipoprotein E 유전자의 다형성
조광현,정상근,황익근,Cho, Gwang-Hyun,Chung, Sang-Geun,Hwang, Ik-Keun 대한생물정신의학회 2003 생물정신의학 Vol.10 No.2
Objectives:Although polymorphisms of apolipoprotein E have been investigated in many neuropsychiatric disorders, results were controversial and even contradictory. The purpose of this study was to investigate the genotypes of apolipoprotein E in schizophrenia and healthy controls, and to compare them in two groups in terms of distribution of apolipoprotein E genotype and allele. Method:Using polymerase chain reaction and amplified refractory mutation system, apolipoprotein E genotypes were identified in 77 schizophrenics and 115 healthy control persons. Results:The results were as follows 1) When genotypes of apolipoprotein E were classified into ${\varepsilon}2/2$, ${\varepsilon}2/3$, ${\varepsilon}2/4$, ${\varepsilon}3/3$, ${\varepsilon}3/4$, ${\varepsilon}4/4$ according to phenotypes, there were no statistical differences in genotypes between two groups 2) In terms of allele frequency, there were also no statistical differences between two groups Conclusion:These results suggest that genotypes and alleles of apolipoprotein E seem to be unrelated to the pathogenesis of schizophrenia.
一側 黑質體破壤 白鼠의 回轉運動에 미치는 Apomorphine의 影響
최인선,조규박,은홍배,김영현,황익근 의과학연구소 1989 全北醫大論文集 Vol.13 No.3
To investigate the role of dopamine D1 and D2 receptors in the rotational behavior of rats with 6-OHDA-lesioned substantia nigra, effects of dopamine agonist and antagonists on the action of apomorphine were examined. 1. Apomorphine induced time-dependant rotational behavior. Maximum effect of apomorphine was observed 4 weeks after denervation. The rotatory effect of apomorphine in apomorphine-primed rat was inhibited by subcutaneous SCH 23390 or sulpiride. 2. SKF 38393 elicited the turning behavior of the apomorphine-primed rats, while the rotatory effect of LY 171555 was potentiated by apomorphine-priming. 3. In rats primed with SKF 38393, SKF 38393 did not elicit the rotatory behavior, but potentiated the action of LY 171555. Otherwise, rotatory effect of SKF 38393 or LY 171555 was potentiated in the rats primed with LY 171555. 4. In the apomorphine-primed rats, the rotatory effect of SKF 38393 was not affected by subcutaneous sulpiride, but inhibited by subcutaneous SCH 23390, while the rotatory effect of LY 171555 was inhibited by SCH 23390 or sulpiride. 5. In the rats treated with apomorphine, SCH 23390, sulpiride or phenoxybenzamine for 4 weeks after denervation, apomorphine potentiated the rotatory effect of apomorphine, while sulpiride or phenoxybenzamine decreased the effect of apomorphine. However, SCH 23390 did not affect the action of apomorphine. 6. In the supersensitivity-developed rats, chronic SCH 23390, sulpiride or phenoxybenzamine significantly decreased the rotatory effect of apomorphine. From the above results, it is suggested that the rotatory effect of apomorphine is due to the activations of dopamine D1 as well as D2, and dopamine D1 is linked to dopamine D2 for its activation.