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장린(Rin Chang),김병호(Byung Ho Kim),장영운(Young Woon Chang),이정일(Jung Il Lee),황이숙(Yi Sook Hwang),김효종(Hyo Jong Kim) 대한소화기학회 1990 대한소화기학회지 Vol.22 No.3
Membranous Obstruction of the Inferior Vena Cava (MOVC) is a raredevelopmental abnormality of the inferior vena cava at the level of diaphragm. Because MOVC secondarily impedes hepatic venous drainage, it causes severe chronic venous congestion and centrolobular fibrosis of liver. MOVC has recently been documented as a risk factor for hepatocellular carcinoma in South African Blacks and Japanese. We report here our experience with a case of MOVC with hepatocellular carcinoma to give special emphasis to the differences in presentation and treatment with classic Budd-Chiari syndrome and the imperative necessity of the surgical correction of the defect with early detection.
간장 ( 肝腸 ) 및 담도 ( 膽道 ) : B형 활동성 간염 환자에서 단기 Prednisolone과 ARA - AMP 겸용 치료의 경과에 따른 면역 지표의 변화에 관한 연구
민영일(Young Il Min),장린(Rin Chang),김병호(Byung Ho Kim),장영운(Young Woon Chang),이정일(Joung Il Lee),황이숙(Yi Sook Hwang),김정원(Jeong Won Kim),김효종(Hyo Jong Kim) 대한소화기학회 1990 대한소화기학회지 Vol.22 No.3
N/A Withdrawal of corticosteroids in patients with chronic type B hepatitis is frequently associated with enhanced cellular immune response to hepatitis B virus. This immunolgic rebound generally results in a transient reduction in levels of HBV-DNA and DNA polymerase, and seldom results in clearance of HBeAg. There was a pilot study that the combination of a short course of prednisone followed by ARA-AMP was potentially synergistic. The object of this study was to determine the effect of short term prednisolone followed by ARA-AMP on the immune system in patients with chronic active ltepatitis-B. Patients were started 40 mg of prednisolone daily for 4 weeks. After prednisolone therapy was discontinued, patients received no medication for 2 weeks. ARA-AMP was then given for 4 weeks at a dose of 500 mg daily. Immune parameters such as T cell subsets, IL, production, NK cell activeity, and LAK cell activity were tested before and during treatement period. The resullts were as follows. 1) Basal IL2 production in CAH-B (71.3 unit/ml) was lower than that of normal control (p<0.025). Basal NK activity, T4/T8 ratio and LAK activity of CAH-B were similar to those of normal control. 2) After prednisolone treatment, IL2 production, NK cell activity and LAK cell activity were significantly lower than those of basal value. 3) After induction of immune rebound, IL, production increased to 84.8 unit/ml (basal 71.3 unit/ml,
한국인 뇌경색증환자에서 위험인자로서의 Lipoprotein (a)
김진우,최영길,김영설,김광원,우정택,황이숙 대한내분비학회 1991 Endocrinology and metabolism Vol.6 No.3
To evaluate the role of Lipoprotein (a) in patients with cerebral infarction in Korea, Lipid parameters were compared with control group. The control group was made up of 45 healthy persons and the patients group of cerebral infarction included 56 patients confirmed by computerized cerebral axial tomography. We tested 111 serum samples using Pharmacia 2-site IRMA kit. The results were as follows: 1) The concentrations of serum Lipoprotein (a) was significantly higher in patients group of cerebral infarction as compared to normal control (55.0±40.7 mg/dl). 2) In patients with cerebral infarction. 66.7% of male and 57.1% of female has serum Lipoprotein (a) concentration above mean normal level (≥29 mg/dl). 3) In female patients with low serum cholesterol group, the mean serum Lipoprotein (a) was higher than high serum cholesterol group (66.3±87.1 mg/dl vs. 51.3±44.0 mg/dl). We concluded that the high serum Lipoprotein (a) may be another risk factor for the cerebral infarction, especially in those who has normarum cholesterol level in Korea. (J Kor Soc Endocrinol 6:232~237, 1991)
성선자극 호르몬 저하성 성선기능 저하증 환자에서 Pulsatile Infusion Pump 를 이용한 성선자극 호르몬 방출 호르몬 ( GnRH ) 치료
김진우,최영길,김영설,김광원,양인명,김성운,황이숙 대한내분비학회 1990 Endocrinology and metabolism Vol.5 No.4
Hypogonadotropic hypogonadism result in absent or incomplete pubertal development, characterised by low plasma gonadotropin and gonadal steroid concentrations, and appears to be due to a deficiency of gonadotropin releasing hormone. We report a case of treatment of delayed puberty after pusatile administration of GnRH in a patient with hypogonadism. A 23 year old man was admitted with complaint of the absent of secondary sex characteristics. Diagnosis of hypogonadotropic hypogonadism was made by combined pituitary stimulation test, chromosomal study and abdominal sonography. GnRH (Luterelef , Ferring Co.) was injected subcutaneously at the interval of 90 min. by infusion pump in doses of 20 g/pulse. Gradual increases of serum gonadotropins, testosteron and sperm count. On fist day of therapy, serum testosteron level and sperm count was 0.6 ng/ml, one million per high power field respectively, and on 20 weeks of therapy, 4.5 ng/ml and 5 million per high power field respectively. GnRH pulse therapy is useful for delayed puberty and infertile man who diagnosed hypogonadotropic hypogonadism (J Kor Soc Endocrinol 5:318 322, 1990).
회장 궤양이 십이지장으로 관통된 Behcet 씨 장염 1예
김병호,이정일,김효종,장린,장영운,황이숙 대한소화기내시경학회 1990 Clinical Endoscopy Vol.10 No.2
Behcets syndrome is a multisystem disorder presenting with recurrent oral and genital ulcers as well as uveitis, Gastrointestinal involvement associated with ileal ulcer is rare, but its outcome may by fatal. We have recently experienced a 43-year-old man who had Behcets syndrome with ileal ulcer penetrated to 3rd portion of the duodenum. He had been updergone right hemicolectomy and ileocolostomy for ileal inflammation of unknown etiology 20 years ago. Thereafter he had had relapsing oral and genital ulcers, and abdominal pain intermittently. From 15 days ago before visiting our hospital, he had severe abdominal pain and dark blood-colored stool. The colonofiberscopic finding revealed a large, deep penetrating ulcer and multiple shallow ulcers on the ileum. Deal segmental resection, gastro-jejunostomy and jejunal patch at 3rd portion of the duodenum were performed with marked improvement.