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김규범,황인선,문창종,신태균,손화영,지영흔,Kim, Gyubeom,Hwang, Insun,Mun, Changjong,Shin, Taekyun,Son, Hwa-young,Jee, Youngheun 대한수의학회 2004 大韓獸醫學會誌 Vol.44 No.3
This study was undertaken to examine the developmental expression of osteopontin(OPN) in the mouse brain. In Western blotting analysis, the expression of OPN was noted initially at embryonic stage and increased gradually after birth and decreased at postnatal day 60(P60). In immunohistochemistry, OPN expression was found in the interstitial nucleus Cajal and the substantia nigra reticularis in anterior part of the brain and in the inferior olivary complex, the parabrachial nucleus, the facial nucleus, the gigantocellular reticular nucleus, the trigeminal nucleus and the anterior interposed nucleus in posterior part of the brain at P31 and P60. In addition, OPN expression in widespread neurons appeared during the period of neuronal differentiation, increased just after birth and decreased with maturation. These results suggest that OPN contributes to developmental processes, including the differentiation and maturation of specific neuronal populations.
자살과 알코올 사용장애를 동반한 기분장애와의 연관성 : 공통 데이터 모델을 활용한 연구
조용혁(Yong Hyuk Cho),이은영(Eunyoung Lee),허은실(Eun Sil Her),황규범(Gyubeom Hwang),임기영(Ki-Young Lim),노재성(Jai Sung Noh),신윤미(Yunmi Shin),홍창형(Chang Hyung Hong),노현웅(Hyun Woong Roh),이동윤(Dongyun Lee),이혜림(Heirim Lee) 대한신경정신의학회 2021 신경정신의학 Vol.60 No.3
Objectives This study determines the effects of comorbidity of mood disorder and alcohol use disorder on suicide behavior. Methods We converted data from the electronic medical records of one university hospital into a common data model and utilized it in our analysis. We selected 9551 patients with diagnosis codes of mood disorders or alcohol use disorders and divided them into three groups: mood disorder (MD) only, alcohol use disorder (AUD) only, and comorbidity of mood disorder and alcohol use disorder (MD+AUD). The mood disorder group was also subgrouped with depressive (DD) or bipolar affective disorder (BD) groups, and the comorbidity group was classified in the same way. Then, we applied logistic regression analysis to assess the risk of suicide attempts between the diagnostic groups. Subgroup analysis according to age also was conducted. Results The MD+AUD group had 2.7 (odd ratio [OR]=2.70, 95% confidence intervals [CI]=1.91- 3.81, p<0.0001) and the DD+AUD group had 2.78 (OR=2.78, 95% CI=1.95-3.98, p<0.0001) times higher risk of suicide attempts than the MD only and DD only group, respectively. Furthermore, according to the age subgroup, the risk of suicide attempts was the highest (OR=5.17, 95% CI=2.35-11.40, p<0.0001) in the DD+AUD group for those aged 40-59. There were no significant results in BD. Conclusion The results showed that the comorbidity of mood disorder and alcohol use disorder could increase suicide risk. This study suggested that alcohol use behavior needs to be assessed as well as mood symptoms for suicide prevention.