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호흡기 알레르기 환자에서 Phadiatop과 혈청 총 IgE 측정의 아토피 선별 효과 비교
장경희 ( Kyung Hee Chang ),홍천수 ( Chein Soo Hong ),이준구 ( Jun Gu Lee ),서정훈 ( Jeong Hun Seo ),백용한 ( Yong Han Paik ),황재하 ( Jae Ha Hwang ),박중원 ( Jung Woo Park ) 대한천식알레르기학회 1998 천식 및 알레르기 Vol.18 No.2
background: Phadiatop test has been introduced as a single test for screening the atopics who were sensitized to common inhalant allergens. Material and method: We compared the clinical efficiency of Phadiatop test and total IgE level for defining presence of atopy in 136 asthmatic subjects. The presence of atopy was defined by skin prick test done with 10 common inhalant allergens. More than 2+ skin reactivity was defined as having atopy. Phadiatop test and total IgE level in serum were measured using Pharmacia CAP systems. Result: 109 out of 136 subjects had more than 2+ skin reactivity to at least one allergen and another 27 subjects had 1+ or negative skin reactivity to allergens. The performance characteristics of Phadiatop test for screening atopy was superior than total IgE level, with sensitivity(91.7% vs. 82.6%), positive predictive value(94.3% vs. 86.5%) and concordance rate(89.0 % vs. 75.7% ). Specificity and negative predictive value of the Phadistop test were acceptable and higher than that of total IgE level. Conclusion: These results suggested that Ph adiatop may be simple and useful for screening atopic status in Korean asthmatic subjects.
이준구,고시환,송정식,황재하,백용한,장윤수,김대중,배상욱,박중원,홍천수 ( Jun Gu Lee,Shi Hwan Ko,Jung Sik Song,Jae Ha Hwang,Yong Han Park,Yoon Soo Jang,Dae Jung Kim,Sang Wook Bae,Jung Woon Park,Chein Soo Hong ) 대한천식알레르기학회 1998 천식 및 알레르기 Vol.18 No.3
Human seminal fiuid (HSP) hypersensitivity is rare, but possibly a life-threatening disease. The pathogenesis of seminal plasma hypersensitivity and the exact nature of the HSP allergens remains to be clarified. We report a case of 25-year-old female patient who complained of severe itching sensation, flushing and edema of external genitalia, facial edema and dyspnea after sexual intercourse. The diagnosis was established by skin pr ick test with her husbands diluted semen. Intravaginal desensitization was performed by modified Matloffs method. Dilutions was made with sterile human serum albumin(0.2%) and 0.4% pheno1-0.9% saline solution. Two ml each of progressively greater concentrations of semen dilutions(1: 100,000 v/v, 1: 10,000 v/ v, 1:1,000 v/v, 1:100 v/v, 1:10 v/v) were inserted intravaginally at 45-min intervals, followed by an undiluted specimen. The patient was successfully desensitized and could have unprotected intercourse without anaphylaxis.