기관지 천식환자에 있어 고장성 생리식염수 흡입을 이용한 유도객담 검사 - 검사법의 확립과 유도객담내 염증세포 관찰 -

강석민(Suck Min Kang),김철우(Chul Woo Kim),박중원(Joong Won Park),홍천수(Chun Soo Hong) 대한내과학회 1997 대한내과학회지 Vol.52 No.6

N/A Objectives: From asymptomatic asthmatic patients unable to produce sputum spontaneously, we performed a non-invasive method obtaining sputum via inhalation of ultrsonically nebulised hyperosmolar saline(3%) which provides a way to investigate airway inflammation, And we also evaluated the effectiveness of the ultrasonic nebulizer in these patients. Methods: 50 asymptomatic patients unable to produce sputum spontaneously inhaled a hyperosmolar saline via an Ultrasonic nebulizer to induce sputum. We examined the quality of the sputum, total cell counts and differential cell counts of eosinophil after sputum processing. Results: 1) The quality of the sputum was uninterpretable (12%); poor(16%); fair(34%); good(38%), repectively. The mean induction time of expectoration was about 10 minutes. 2) The most common complaint was of a salty taste(45 cases). The mean fa11 in peak expiratory flow rate during inhalation of saline was 4.0% and the fall more than 20% was observed in 5 cases. 3) The mean eosinophil percent in induced sputum was 38.5%, The mean value of the total IgE and total peripheral eosinophil count was 818.2 IU/ml, 401.2/mm³ respectively, 4) There were no relationships between the sputum eosinophil count(%) and both the total IgE and the PC20(r=0.13, r=0.18). There was also an insignificant correlation between the sputum eosinophil count(%) and the total peripheral eosinophil count(r=D.22). Conclusion: We find that there are many eosinophils within induced sputum via inhalation of ultrsonically nebu1ised hyperosmolar saline from asymptomatic asthmatic patients unable to produce sputum spontaneously, Therefore we suggest that an induced sputum study via inhalation of hyperosmolar saline is useful to determine a patient`s status of airway inflammation.

증례 : 뇌하수체종양에 동반된 뇌하수체농양 1 예

허갑범 ( Kap Bum Huh ),이상용 ( Sang Yong Lee ),이현철 ( Hyun Chul Lee ),임승길 ( Sung Kil Lim ),이강석 ( Kang Sug Lee ),홍천수 ( Chun Soo Hong ) 대한내과학회 1984 대한내과학회지 Vol.27 No.12

Hydrogen Sulfide 생성 Escherichia coli 및 Salmonella paratyphi-A의 분리

정윤섭(Yun Sop Chong),김진주(Jin Ju Kim ),권오헌(Oh Hun Kwon),이삼열(Samuel Y. Lee),윤진우(Jhin Woo Yoon),홍천수(Chun Soo Hong ),이복권(Bok Kwon Lee) 大韓微生物學會 1985 大韓微生物學會誌 Vol.20 No.2

Freloxacin과 Ciprofloxacin의 호기성 그람음성 간균에 대한 시험관내 항균력

김준명,정윤섭,이삼열,홍천수 대한감염학회 1989 감염 Vol.21 No.3

Fleroxacin is a fluorinated 4-quinolone compound with broad specturm activity. In this study the antibacterial activities of fleroxacin and ciprofloxacin against Enterobacteriaceae, Pseudmonas and Acinetobacter anitratus isolated in 1988-89 from patients of Severance Hospital were tested by the agar dilution method. The minimum inhibitory concentrations (MCIs) of fleroxacin were 2㎍/ml against Enterobacteriacease except for a few isolates of Klebsiella pneumoniae. The MICs were 16㎍/ml against Pseudomonas and 4㎍/ml against A.anitratus. The MICs of fleroxacin were slightly higher than those of ciprofloxacin, but the frequencies of sucseptibility of Enterobacteriaceae against fleroxacin and ciprofloxacin were the same. 6-20% of Pseudomonas, depending on the species, and none of A. anitratus were resistant to fleroxacin. From this in vitro study, fleroxacin can be considered to be a useful drug for the treatment of infections due to aerobic gram-negative bacilli.

한국인에서 Coxiella burnetii PhaseⅡ 항원에 대한 항체 보유에 관한 연구

김주덕,조상래,김준명,이천균,김현옥,정윤섭,김 응,홍천수 대한감염학회 1994 감염 Vol.26 No.4

연구배경: 우리나라에서도 오래전부터 Q열의 발생이 예견되어오던 중 최근들어 Q열의 발생에 대한 간헐적인 보고가 있으면서 Q열의 원인체인 C.burnetii 감염상태를 알아보고자 하는 혈청역학적조사가 진행되어 보고된 바 있으나 이들 보고가 C.burnetii phase I 항원에 대한 항체 양성률에 근거 하였기에 이를 보완하고 보다 정확한 감염상태를 알아보고자 본 연구를 시행하였다. 방법: C.burnetii에 가장 감염 가능성이 높은 것으로 생각되는 목축업자 58명과 농민 25명을 대상으로 간접 형광 항체 검사법을 통하여 C.burnetii phase Ⅱ 항원에 대한 항체를 측정하였으며, 동시에 도시주민 71명에 대해서도 함께 조사하였다. 결과: 1) 농민 25명중 48.0%인 12명이 그리고 목축업에 종사하는 58명중 39.7%인 23명이 항체 양성을 보였고 도시주민 71명중 19.7%인 14명이 항체양성이었다. 2) 양성혈청의 74%(36례)가 항체 역가 1:20 또는 1:40의 양성반응을 나타내어 항체 양성자 대부분은 항체가가 비교적 낮았으며 항체 역가 1:80 이상을 보인 경우가 13례로서 양성혈 청의 27%였다. 3) 연령별 항체양성률 조사상 연령이 증가할수록 항체양성률이 중가하였는데, 10대에서는 항체 양성인례가 없었으며, 20대에서는 16.7%, 30대에서는 34.1%, 40대에서는 34.6%, 50대에서는 45.0%, 60대에서는 46.0%, 70대에서는 50.0%의 항체양성률을 보였다. 결론: 과거부터 우리나라에도 유입되었으리라 여겨졌던 C.burnetii 감염이 이미 상당수 존재하고 있음을 알 수 있었으며 이에 대한 광법위한 혈청역학적 조사와 함께 일선 임상의의 Q열에 대한 관심과 주의가 요구된다 하겠다. Background : Q fever is a worldwide zoonosis caused by Coxiella burnetii, and it manifests an influenza-like illness and pneumonia. Q fever was reported in more than 50 countries of five continents. In Asia, India, Saudi Arabia, Japan, and China Q fever had already occurred. In Korea no outbreaks of Q fever have been reported yet, although some potentials of a Q fever outbreak has been suggested on the basis of epidemiologic background. As recently several cases of Q fever have been reported, seroepidemiological surveys to determine the prevalence of Coxiella burnetii infection among Koreans were done. But these surveys had limitations. That is to say, while immunoglobulins produced during acute phase of Q fever are mainly directed against the phase Ⅱ antigen of the microorganism, these previous surveys were done with the phase I antigen, which is low titer during acute phase. Therefore to resolve this limitation and evaluate the prevalence of Q fever in Korea more exactly, we conducted this serosurvey with the phase Ⅱ antigen. Methods : We conducted a serosurvey for 58 stock breeders and 25 farmers who seemed to be a high risk group for the Coxiella burnetii infection and normal residents in a city. With use of an indirect immunofluorescent antibody test(IFA) employing the phase Ⅱ antigen of the Nine-Mile strain of Coxiella burnetii, the titer of polyvalent immunoglobulins was determined. Results:1) When IFA titer of 1:20 or above was considered seropositive, 23(39.7%) of 58 stock breeders and 12(48.0%) of 25 farmers were seropositive respectively.Fourteen(19.7%) of 71 city residents had elevated antibodies to the Coxiella burnetii phase Ⅱ antigen. 2) IFA titers ranged from 1:20 to 1:320, but the majority of the seropositive samples showed IFA titers of 1:20 or 1:40 indicating that in a majority of the seropositves C. burnetii infection progressed weakly or antibody titer decreased because of the long duration after the infection. 3) As the age increased, a positive rate of antibody to Coxiella burnetii phase Ⅱ antigen also increased. Conclusion : Our study suggests that Coxiella burnetii infection occurs in Korea more widely than expected and thus more extensive serosurvey and clinician's attentions for Q fever are required.

기관지 천식의 치료 : 약물요법(Ⅰ)

홍천수 한국의학사 1997 診斷과治療 Vol.17 No.2

기관지 천식의 진단

홍천수 한국의학사 1997 診斷과治療 Vol.17 No.1

호흡기 알레르기 환자의 자기관리와 환경관리

홍천수 한국의학사 1997 診斷과治療 Vol.17 No.4

AIDS 환자에서 Zidovudine 부작용으로 사료되는 식도궤양 1예

홍천수,전재윤,김준명,남동호 대한감염학회 1993 감염 Vol.25 No.3

Zidovudine is an important drug which has been shown to prolong the survival in patients with human immunodeficiency virus (HIV) infection. However some adverse reactions such as bone marrow suppression and gastrointestinal disturbances such as a nausea and vomiting have been observed. Recently, we experienced a case of esophageal ulceration in a patient with acquired immunodeficiency syndrome (AIDS) on the Zidovudine therapy. A 33-year-old female who received Zidovudine developed a swallowing difficulty and substernal chest pain. At endoscopy multiple esophageal ulcerations were seen in the distal esophagus. Histologic examination revealed necrotic inflammation and no viral inclusions or fungi were seen. After discontinuing Zidovudine her symptoms resolved completely. Endoscopic follow-up after 2 weeks showed marked healing of ulcerations. We report this case with a review of the literature.

환자와 자연환경에서 분리된 Aeromonas의 균종 및 항균제 감수성

정윤섭,이삼열,홍천수,고춘명,곽창길 대한감염학회 1987 감염 Vol.19 No.3

Aeromonas is known to cause gastrointestinal as well as various extraintestinal infections in man. Strains of Aeromonas isolated from mam used to be identified as A. hydrophila, but other species is now known to cause infection. In this study, strains of Aeromonas isolated from clinical materials during July 1983 to December 1986 and identified as A. hydrophila were reexamined to ascertain presence of other species. Also attempted was to isolate Aeromonas from environmental sources during September to October 1986. Identification of species were done by various biochemical tests. Antimicrobial susceptibility was tested by the agar dilution method. Among the clinical isolates 15 were A. hydrophila, 7 A. sobria and 4 A. caviae. From the environment 11 were A.sobria, 7 A. hydrophila and 2 A. caviae. A. hydrophila as well as A. sobria (7) and A. caviae (4) were isolated from such specimens as wound, blood and bile. From environmental sources, fish bowl water often yielded the organism. The isolates included 10 A. sobria, 6 A. hydrophila and 2 A. caviae. All of the isolates were susceptible to amikacin, gentamicin, tobramycin, cefotaxime and ciprofloxacin, most were susceptible to cefamandole, cefoperazone, cefoxitin, cefuroxime, moxalactam, chloramphenicol and tetracycline, and a few were susceptible to cefazolin and cotrimoxazole. All were resistant to ampicillin. It is concluded that from clinical materials A. hydrophila as well as A. sobria and A. caviae are isolated, that among the environmental isolates A. sobria outnumber others, and that the most active antimicrobial agents are aminoglycosides, cefotaxime and ciprofloxacin.