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이온성 혈관조영제 Talabrix가 동맥혈관내막과 미세혈관 문합 후 혈관개폐에 미치는 영향
홍순원,김용욱,탁관철,박병윤 大韓成形外科學會 1993 Archives of Plastic Surgery Vol.20 No.1
In the free flap surgery using microvascular anastomosis, angioraphy is widely used as an integral part of preoperative plans. The necessity of angiography is well extablished. But since there exist many controversies regarding adverse effects of angiography. especially there is no concrete evidence about their effects on the patency after microvascular anastomosis, This study attempts to examine the chronological changes of the arterial intima after systemic injection of ionic contrast media sodium iothamate(Talabrix ) and to evaluate its effects on the patency of microvascular anastomosis. Fifty-nine Sprague Dawley rats were divided into 5 groups according to time interval between contrast media injection and microvascular anastomosis. The time intervals were 1 day, 3 days, 7 days, and 14 days after contrast media injection. The ionic contrast media was injected intraveneously through the tail vein. Left inguinal arteries were anastomosed under an operating microscope after the contrast media injection. After the above procedures and reviewing all the results, we can conclude that ionic angiographic dye causes reversible injuries to the vascular intima, and deteriorates patency of the microvascular anastomosis. And we suggest that a time interval more than at least 7 days to 14 days, between anguographic study and flap transfer is requested.
무기수은을 투여한 흰쥐에서의 신장독성에 대한 착화제 효과 및 병리조직학적 변화
고상백,홍순원,차봉석 大韓産業醫學會 1997 대한직업환경의학회지 Vol.9 No.2
This study was to determine the effects of Sodium-N-[4-methoxybenzyl]-D-glucamine-N-dithiocarbamate (MeOBGDTC) on the nephrotoxicity of mercury and histopathological change in rats pretreated with mercuric chloride 48h earlier. In a first experiment, 3 groups were given a single injection i.p. of 3.5㎛ol/Kg of Hgcl₂ mixed with 1μCi of 203Hg²+ in a final volume of 0.5ml of physiologic saline. Subsequently the rats also received the chelator, 1mmol/Kg of MeOBGDTC, at 1h in group 2 (Hgcl₂-MeOBGDTC 1h) and 12h in group 3 (Hgcl₂-MeOBGDTC 12h) after injection of mercuric chloride. The results showed that the injection of chelating agent at 1h after mercury injection significantly decreased mercury level in plasma. But not significant in renal cortex. In a second experiment, rats were divided into 4 groups, one group was control group, others were mercury injected group. MeOBGDTC was also administered to mercury-injected, rats as described above. The changes in renal function were determined by measurement of proteinuria, plasma creatinine and urinary osmolality. The results showed that the injection of mercuric chroride incrased the excretion of urinary protein and plasma creatinine, and decreased the urinary osmolarity. However, the injection of chelating agent at 1h after mercury injection significantly decreased the toxic effects of mercury. Finally, histopathological change at the light microscopic level was comparable effect of chelating agent on nephrotoxicity of mercury. Minimal morphological alterations were seen in kindly of rats of Hgcl₂-MeOBGDTC 1h. The Hgcl₂-MeOBGDTC 12h caused necrotic change of the proximal tubule at cortical-medually junction. These changes were more common and more severe at the Hgcl₂alone.
호산구성 육아종에 병발된 동맥류성 두개골 골낭종 : 증례보고 Case Report
길승배,허철,변진수,한용표,김헌주,홍순기,김명순,홍순원,김윤미 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.9
A case of aneurysmal bone cyst(ABC1 secondary to eosinophilic granuloma of the skull is reported. In the skull the presence of ABC secondary to eosinophilic granuloma is rare. We reviewed the clinicopathological and radiological features of this type of eocinophilic granuloma at the cranium.