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백반증 환자에서 308 nm 엑시머 레이저 치료 효과에 관한 연구: 한국의 단일기관 연구
홍광철 ( Kwang Cheol Hong ),김명신 ( Myoung Shin Kim ),이운하 ( Un Ha Lee ),박현수 ( Hyun Su Park ) 대한피부과학회 2013 대한피부과학회지 Vol.51 No.10
Background: Treatment with a 308 nm excimer laser has been used widely for vitiligo. However, there have been few clinical reports about the therapeutic effects of excimer laser in the Korean literature. Objective: The purpose of this study was to investigate the clinical efficacy of treatment of vitiligo patients in Korea using a 308 nm excimer laser. Methods: Eighty-five patients were treated using a 308 nm excimer laser, which was performed twice a week, for a total of 20 treatments. We analyzed the grade of repigmentation with respect to various clinical parameters. Results: Thirty-one of the 85 patients (36.5%) achieved more than 50% repigmentation. Response to treatment was related to age, duration of vitiligo, type of vitiligo and site of lesions (respectively, p=0.049, 0.030, 0.001, 0.001). There were no relationship between treatment response, sex and history of previous treatments (respectively, p=0.636, 0.781). Twenty-nine patients (34.1%) had side effects including erythema, perilesional hyperpigmentation and burn, but they were mild and transient. Conclusion: The use of a 308 nm excimer laser for the treatment of vitiligo patients is effective and safe. However, patient age, duration of vitiligo, type of vitiligo and site of lesions may be the key factors affecting the clinical outcome. (Korean J Dermatol 2013;51(10):755∼762)
홍광철 ( Kwang Cheol Hong ),노태우 ( Tae Woo Noh ),백종헌 ( Jong Heon Baek ),이동엽 ( Dong Yeob Lee ),강유석 ( Yoo Seok Kang ),이운하 ( Un Ha Lee ),박현수 ( Hyun Su Park ) 대한피부과학회 2012 대한피부과학회지 Vol.50 No.7
An 82-year-old woman presented with a 5-year history of erythematous to brown patches and plaques on both legs, arms and trunk. Histopathological findings of biopsy specimens were consistent with mycosis fungoides, and the tumor cells were positive for CD3 and negative for CD20 in immunohistochemical stain. Imaging studies proposed the suspicion of ureter cancer, and the result of cystoscopic biopsy showed papillary urothelial carcinoma. Mycosis fungoides is the most common type of cutaneous T-cell lymphoma, characterized by variable cutaneous manifestations, including patches, plaques, tumors, and erythroderma. There were several studies concerning the evaluation of the second malignancy risk after cutaneous T-cell lymphoma, however the relationship between mycosis fungoides and ureter cancer is not revealed. This patient is considered a case of mycosis fungoides with coincidental ureter cancer. (Korean J Dermatol 2012;50(7):632∼635)
홍광철 ( Kwang Cheol Hong ),김성현 ( Seong Hyun Kim ),김명신 ( Myoung Shin Kim ),이운하 ( Un Ha Lee ),박현수 ( Hyun Su Park ) 대한피부과학회 2013 大韓皮膚科學會誌 Vol.51 No.8
Background: The eyelids are uniquely susceptible to inflammation. Although eyelid dermatitis is common by various causes, there are few comprehensive studies on this disease in the Korean literature. Objective: The purpose of this study was to analyze the causative disease for eyelid dermatitis in Koreans. Methods: Medical records of patients with eyelid dermatitis treated between 2006 and 2011 were reviewed. Results: Four hundred and five patients (152 males and 303 females) were enrolled in this study, and the mean age of onset was 32.7 (range: 0∼84). The most common causes of eyelid dermatitis were allergic contact dermatitis (42.6%), atopic dermatitis (27.9%), irritant contact dermatitis (12.7%), seborrheic dermatitis (8.6%), insect bite (2.4%), etc., in the order of frequency. In the 194 patients of eyelid dermatitis caused by allergic contact dermatitis, 98 patients (50.5%) were in the 30`s to 50`s, and 120 patients (94.5%) of the 127 patients with atopic dermatitis were under thirty years of age. The frequency of causative diseases for eyelid dermatitis in men were atopic dermatitis (44.7%), allergic contact dermatitis (23.7%) and irritant contact dermatitis (12.5%), and those in women were allergic contact dermatitis (52.1%), atopic dermatitis (19.5%) and irritant contact dermatitis (12.9%). There was a seasonal variation with frequency in fall (30.3%) and spring (26.4%). Among the 341 patients who were followed up, 294 patients (86.2%) showed good response to treatment, but 64 patients (21.8%) of the improved 294 patients relapsed. Four patients experienced adverse effects including irritation (3 cases) and folliculitis (1 case) after using topical glucocorticoids. Conclusion: The frequency of eyelid dermatitis decreased by age. Eyelid dermatitis was more common in women, but the ratio of males to females was increased compared with previous reports. The most common causes of eyelid dermatitis were allergic contact dermatitis, atopic dermatitis and irritant contact dermatitis, which were similar with the results of previous reports. Eyelid dermatitis was more common in fall and spring. The recurrence rate was relatively high, but adverse effects of topical corticosteroids were unusual. This study will be useful for clinicians when treating patients with eyelid dermatitis. (Korean J Dermatol 2013;51(8):579∼585)
Intense Pulsed Light를 이용한 목과 가슴의 Poikiloderma 치험
홍광철 ( Kwang Cheol Hong ),백종헌 ( Jong Heon Ba다 ),이운하 ( Un Ha Lee ),박현수 ( Hyun Su Park ) 대한피부과학회 2013 대한피부과학회지 Vol.51 No.9
Poikiloderma is a combination of telangiectasia, irregular mottled hyperpigmentation/depigmentation and superficial atrophy in a reticular pattern. Poikiloderma of Civatte is a rather common, acquired poikiloderma of the face and neck, most often affecting the middle-aged or the elderly. Poikiloderma of Civatte runs a chronic, benign, but irreversible course. The ideal treatment is elimination of both the vascular and pigmented components simultaneously. Most methods to treat this condition are ineffective, inefficient, or inconvenient and may cause significant side effects such as depigmentation and scarring. Recently, intense pulsed light sources have been used in poikiloderma of Civatte with their ability to target vascular and pigment components simultaneously. We experienced two cases of poikiloderma of Civatte treated by intense pulsed light with different parameters than those used in former reports,so we report this case with a review of previously published cases.