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Isoniazid를 포함한 항결핵약제 투여 후 발생한 여성형 유방 증례
허은영 ( Eun Young Heo ),정인아 ( In A Jeong ),이재석 ( Jae Seok Lee ),이창훈 ( Chang Hoon Lee ),정희순 ( Hee Soon Chung ),김덕겸 ( Deog Kyeom Kim ) 대한결핵 및 호흡기학회 2008 Tuberculosis and Respiratory Diseases Vol.65 No.4
Gynecomastia is a benign enlargement of the male breast attributable to proliferation of the ductal elements. Gynecomastia has been rarely reported as an adverse effect of isoniazid therapy. We report the case of a 35-year-old man who was prescribed with isoniazid, rifampicin, ethambutol and pyrazinamide to treat pulmonary and lymphatic tuberculosis. After five months of treatment, the patient complained of painful engorgement in the bilateral breasts and the presence of male gynecomastia was confirmed with a physical examination and radiographical methods. The serum level of estradiol was also increased. Common causes of male gynecomastia were excluded through history taking and the laboratory findings. The anti-TB drugs were changed to a second line regimen due to radiographical progression and the intolerance of the patient to gynecomastia. Gynecomastia was relieved very slowly and a tender subareolar palpable mass decreased in size and consistency over five-month period after stopping the probable causative drug, isoniazid. From a review of the literature, gynecomastia has been shown to be a side effect of treatment with first line anti-tuberculosis drugs, and especially with isoniazid. We report the rare case. (Tuberc Respir Dis 2008;65:308-312)
허은영 ( Eun Young Heo ),황보지혜 ( Ji Hye Hwangbo ),이윤희 ( Yoon Hee Lee ),김미주 ( Mi Ju Kim ),배진영 ( Jin Young Bae ),성원준 ( Won Joon Seong ) 대한산부인과학회 2011 Obstetrics & Gynecology Science Vol.54 No.5
Pregnancy is a rare event in patients with cirrhosis. But recently, improvements in the treatment of chronic liver disease have resulted in higher conception rates and more successful pregnancy outcomes. A 32-year-old woman with liver cirrhosis underwent cesarean section due to aggravated preeclampsia at 31 3/7 weeks of gestation. After 3 days postoperatively, she complained abdominal distension, and abdominal sonography showed massive amount of ascites. Following paracentesis and administration of diuretics, her course was uneventful. There are increasing numbers of case reports and case series of pregnancy in liver cirrhosis. Nevertheless, morbidity and mortality remains higher than that of the general pregnant population. It is therefore important for physicians caring for pregnant patients with cirrhosis to understand how to approach potential complications and tailor management regimens appropriately.