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소화성궤양 출혈환자에서 내시경적 Submucotic Fibrin Glue 투여에 따른 지혈효과 및 궤양치유 효과 - 항산화작용 및 ODC 활성도 변화를 중심으로
함기백(Ki Baik Hahm),신용준(Yong Joon Shin),원욱희(Ook Hee Won),정재복(Jae Bock Chung),이상인(Sang In Lee),박인서(In Suh Park) 대한소화기학회 1995 대한소화기학회지 Vol.27 No.1
N/A Background/Aims: Acute gastrointestinal bleeding is one of the commonest complication of peptic ulcer diseases. The routine use of emergency endoscopy has led to the development of various endoscopic techniques for hemostasis. Submucotic fibrin adhesion using fibrin glue is a new therapeutic option in endoscopic hemostasis, based on the action of physiological two-components of fibrinogen and thrombin. There were increasing numbers of report which suggests the involvement of reactive oxygen intermediates(ROIs) in a variety of pathological events including peptic ulcers. This study was aimed to know the hemostatic effects of submucotic fibrin glue and involvement of scavenging ROIs in ulcer healings. Methods: Mucosal biopsied specimens(3 5 pieces) were obtained from 23 patients who underwent emergency endoscopy due to upper GI bleedings. Endoscopic examinations were repeated 1 and 4 weeks after endoscopic injection of fibrin glue(l ml, Behringwerke, Germany). Using mucosal homogenates, thiobarbituric acid reac- tive-substances(TBARS, nmol/mg protein) levels, myeloperoxidase(MPO, U/mg protein) activities, chemiluminescence(CL, luminol(300 pM)- or lucigenin(300 pM)-enhanced, photon emmission minus background activities were measured, respectively. Results: Definite hemostasis of Forrest's stage I or II were noted in 19 out of 23 patients(82.6%) after submucotic fibrin glue injections and the ulcers of Forrest's stage I or II were finally converted to Forrests stage III. In only 2 cases(8.7%), the rebleeding occurred, but was controlled with secondary injection. At 4 weeks after submucotic fibrin glue injection, the active stage of ulcers was converted to scarring stage in 18 out of 20 cases(90.0%). The remaining two cases were in a healing stage. The ODC activities measured at l week after submucotic fibrin glue were increased significantly than those measured before(p<0.05). The TBARS and MPO activitics were significantly decreased at 4 weeks after submucotic fibrin glue injection than before(p<O,OS). As ulcers were healed, the chemiluminescence uctivities of mucosal homogenates were decreased significantly. Conclusion: Endoscopic injections of 1 ml of submucotic fibrin glue might hc effective in either immediate hemostasis or accelerated healings of peptic ulcers. Scavenging the Rols might be an important cause or consequence in the healing of peptic hemorrhage. Further study will be required to know whether submucotic fibrin has antioxidant actions or not.(Korean J Gastroententerol 1995;27:18-30)
합병증이 병발된 난치성 염증성 장질환에서 Infliximab의 치료 효과
이기명 ( Ki Myung Lee ),김종수 ( Jong Soo Kim ),신도현 ( Do Hyun Shin ),정재연 ( Jae Youn Cheong ),유병무 ( Byung Moo Yoo ),김재근 ( Jai Keun Kim ),이광재 ( Kwang Jae Lee ),함기백 ( Ki Baik Hahm ),김진홍 ( Jin Hong Kim ),조성원 ( 대한소화기학회 2004 대한소화기학회지 Vol.44 No.5
Background/Aims: Many studies on infliximab have confirmed its efficacy in the remission induction and even maintenance in refractory and fistulizing Crohn`s disease. We report the treatment efficacy of infliximab in Crohn`s disease and ulcerative colitis
최기석(Ki-Seok Choi),이소정(So-Jung Lee),이정상(Jeong-Sang Lee),홍경숙(Kyung-Sook Hong),김정곤(Jeong-Gon Kim),김윤재(Yoon-Jae Kim),함기백(Ki-Baik Hahm) 고려인삼학회 2009 Journal of Ginseng Research Vol.33 No.4
구강악취 원인 물질인 H₂S를 발생시키는 NaHS로 RAW264.7 세포를 자극시킨 결과, VSCs 생성에 관련된 CSE 유전자 발현증가와 함께 IL-6, COX-2, iNOS와 같은 염증매개 cytokine이 증가하며, 아울러 본 대식세포나 백혈구 활성에 관련된 세포내 골격단백질인 ERM의 발현증가가 유도되었다. 이러한 사실은 이전의 연구결과인 VSCs의 생성이 위점막 염증 및 손상과 연관되어 있다는 이전의 연구를 증빙해주는 사실인데, 더욱 흥미로운 사실은 고려 홍삼의 전처치를 통하여 CSE의 억제는 물론 염증 연관 cytokine 및 ERM의 발현억제를 유도할 수 있으며, 이는 세포내 신호전달계인 p38 및 ERK의 억제, 주로는 ERK 비활성화를 통하여 작동됨을 규명하였다. 고려홍삼이 구강악취 환자에게서 증상 완화내지는 소멸을 위하여 매우 유용하다는 이전의 연구결과에 본 연구결과가 추가됨으로 고려홍삼에 의한 VSC 생성억제 기전이 관련된 유전자의 약화는 물론 cytokine 억제 및 백혈구 활성에 관련된 인자억제를 통한 항염증 작용에 근거한다는 기전을 추가할 수 있었다. Halitosis is a generally accepted marker of diseases in the oral cavity and of systemic and gastrointestinal disorders. Based on these authors’ previous findings (that (1) there is a close association between H. pylori infection and halitosis; (2) Korea red ginseng may suppress the colonization of H. pylori, fight H. pylori-induced cytotoxicity, and impose significant anti-inflammatory actions in patients with chronic gastritis; and (3) H. pylori infection is linked with the generation of significant levels of volatile sulfur compounds (VSCs), and the levels of VSCs correlate significantly with H. pylori-associated mucosal damages), in the current study, the authors documented the molecular mechanisms of Korea red ginseng’s efficacy in ameliorating halitosis. When the RAW 264.7 cells were treated with the H₂S releasing compound NaHS, the mRNA expression of cystathionine γ-lyase (CSE), IL-6, COX-2, and iNOS were more significantly induced compared with the vehicle-treated group. The cytoskeletal components of ezrin’s and moesin’s mRNA expressions were elevated by NaHS treatment accompanied by the activation of MAPK, p38, and ERK. Korea red ginseng pretreatment reduced both the NaHS-induced CSE expression and the proinflammatory genes (e.g., IL-6, COX-2, and iNOS) in a concentration-dependent manner. The ERM expression and the phosphorylation of p38 were also significantly reduced by Korea-red-ginseng pretreatment. Overall, Korea red ginseng pretreatment imposed significant anti-inflammatory effects through the downregulation of the NaHS-triggered proinflammatory gene expression, CSE, and ERM mRNA expression. Korea red ginseng could thus be said to be a key remedy of halitosis and to be effective in relieving gastric inflammation.
이기명(Ki Myung Lee),함기백(Ki Baik Hahm),조성원(Sung Won Cho),오태영(Tae Young Oh),최설민(Seul Min Choi),김정훈(Jung Hoon Kim),안병욱(Byoung Ok Ahn),권종원(Jong Won Kwon),김원배(Won Bae Kim) 한국응용약물학회 2002 Biomolecules & Therapeutics(구 응용약물학회지) Vol.10 No.1
N/A Silymarin and curcumin have been used for supportive treatment of liver disease of different etiology due to their hepatoprotective activities. The present study was carried out to investigate the hepatoprotective effects of silymarin and/or curcuma extract against hepatotoxins induced liver injury. To investigate hepatoprotective effects, the silymarin and/or curcuma extract were pre-treated orally to experimental animals. And thereafter a single dose of hepatotoxin, carbon tetrachloride (CCl_4) and acetaminophen were administered through oral or intraperitoneal route, respectively. Chronic liver damage was induced by subcutaneous injection of CCl_4 for 3 weeks (2 times/week). Hepatoprotective and therapeutic effects were monitored by estimating serum ALT and AST levels and by measuring hepatic glutathione (GSH) and malondialdehyde (MDA) levels. Collagen type 1 was detected with immunostaining to assess fibrosis. The results showed that the mixture of silymarin and curcuma extract significantly reduced serum biochemistry levels and MDA levels compared with those of control group in both acute and chronic animal models. In antifibrotic effect, the relative hepatic collagen content was significantly decreased by silymarin and/or curcuma extract treatment. It was concluded that the complex of silymarin and curcuma extract have a both hepatoprotective and therapeutic effect synergically in rat liver injury induced by heptotoxins.