블록체인 기술 개발의 국제 무역시스템 연동으로 국제무역 및 국제금융거래 활성화에 대한 연구*

한수범(Soo-Beom Han) 한국무역연구원 2021 무역연구 Vol.17 No.1

Purpose This study aimed to study how well blockchain technology is operating in conjunction with trade and financial transactions in the international trade system as it develops;and what challenges should be solved in commercializing digital assets;a means of payment. Design/Methodology/Approach The data used in this study sets the scope of utilization around digital asset exchanges. It also wants to analyze the applicability of trade finance by focusing on the examples of companies that are currently engaged in financial transactions. Findings The result of the study is that blockchain technology is still in the early stages of development;so it should be free from various regulations. Research Implications In order to standardize blockchain technology;there remains a task to quantify. And since there is still a lot of inaccurate data;research on the use of blockchain technology in trade finance is likely to take place after standardization-based statistics are established.

한ㆍ중 모바일 뱅킹 이용자의 재이용에 대한 연구

한수범(Soo-Beom, Han) 국제e-비즈니스학회 2013 e-비즈니스 연구 Vol.14 No.5

스마트3.0시대에 따른 신기업비즈니스모델과 마케팅전략

한수범(Soo Beom, Han),최창열(Chang Youl, Choi) 국제e-비즈니스학회 2014 e-비즈니스 연구 Vol.15 No.6

구독서비스 소비자의 사용의도에 미치는 요인:UTAUT2모형을 중심으로

한수범(Soo Beom Han),이도형(Do Hyung Lee) 국제e-비즈니스학회 2021 e-비즈니스 연구 Vol.22 No.6

흡연량과 흡연 기간에 따른 치주 상태

계승범,한수부,Kye, Seung-Beom,Han, Soo-Boo 대한치주과학회 2001 Journal of Periodontal & Implant Science Vol.31 No.4

The purposes of this study were to investigate the relationship between cigarette smoking levels and periodontal status. 199 subjects, consisting of male 127 and female 72, classified by smoking levels and duration were selected: Patients who had smoked for more than 20 cigarettes/day were considered heavy smokers, 10 to 19, moderate smokers; 1-9, light smokers:0, non-smoker. And smokers were divided into ones who had smoked for more than 20 years, 10-19 years, less than 10 years and non-smokers. Heavy smokers and moderate smokers showed significantly greater pocket depths, less clinical attachment levels, more molar furcation involvements, greater alveolar bone loss and higher scores of plaque index than light smokers and non-smokers,(p < 0.05). When the duration of smoking was considered as a factor, scores of clinical parameters were worse and alveolar bone loss were significantly greater in long-term smokers, who had smoked for more than 20 years. In conclusion, cigarette smoking is associated with periodontal status.

구연산과 테트라싸이클린으로 처리한 치근면에서 rhBMP-2가 치주인대섬유아세포와 골아세포의 활성에 미치는 영향

심정민,한수부,설양조,이용무,김경화,계승범,최상묵,정종평,Shim, Jung-Min,Han, Soo-Boo,Seol, Yang-Jo,Lee, Yong-Moo,Kim, Kyeong-Hwa,Kye, Seung-Beom,Choi, Sang-Mook,Chung, Chong-Pyoung 대한치주과학회 2001 Journal of Periodontal & Implant Science Vol.31 No.1

The goal of Periodontal treatment is predictable periodontal regeneration. But until now, many products including GTR materials and growth factors are beyond of complete regeneration. BMP can induce ectopic bone formation when implanted into sites such as rat muscle and can greatly enhance healing of bony defects when applied exogenously. BMP can promote periodontal regeneration by their ability to stimulate new bone and new cementum formation. But little is known about optimal conditions required for the application. Root conditioning is used for bioacive root change so altered root surface provides a substrate that promotes chemotaxis, migration and attachment of peridontal cells encouraging connective attachment to the denuded root surface. The aim of this study is to investigate whether the acid conditioning change effect of rhBMP-2 on human periodontal ligament cell and osteoblast cell line. 288 periodontally involved root dentin slices are divided into 6 groups, each 48, 1)control, 2)treated with BMP, 3)treated with citric acid 4)treated with citric acid+BMP 5)treated with tetracycline 6)treated with TC+BMP. Each group was devided half, so 12 root dentin slices were seeded with periodontal ligament cells and 12 were seeded with osteoblasts. At day 2 and 7, cell number, protein assay, ALP activitiy was measured. To investigate morphology of cultured cells, SEM was employed. Statistical analysis was performed with SPSS 8.0 either t-test or ANOVA test. The results are ; Protein assay and cell number was slightly decreased in CA+BMP group compared to Ca group but it was not statistically significant and ALP activity was much more increased in CA+BMP group compared to CA group so there was no statistically significance between BMP and CA+BMP group and statistically significant compared to control group. Cell number and protein assay was slightly increased in TC group and ALP activity was much less the BMP group and CA group. Cell number and protein and ALP activity was not much increased in TC+BMP group. TC group and TC+BMP group showed cell morphology change in SEM. This results suggested that application of root surface with citric acid before BMP treatment might give better result in periodontal regeneration.

테트라싸이클린 및 테트라싸이클린-구연산 혼합젤로 처리한 치근면의 항 미생물 활성 변화에 관한 연구;In Vivo Study

정희선,한수부,남석우,심창구,계승범,Cheong, Hee-Sun,Han, Soo-Boo,Nam, Seok-Woo,Shim, Chang-Koo,Kye, Seung-Beom 대한치주과학회 1997 Journal of Periodontal & Implant Science Vol.27 No.1

The purpose of this study was to evaluate the substantivity of experimentally developed gel type tetracycline HCl and a mixture of tetracycline-citric acid gel, and compare to those of solution type tetracycline HCl. 11 extracted anterior teeth were subjected to this study. After scaling and root planing teeth were randomly divided into 3 treatments groups : group 1; 3 teeth were irrigated with tetracycline HCl(50mg/ml) solution , group 2; tetracycline gel (5%) was inserted in the periodontal pockets of 3 teeth, group 3; a mixture of tetracycline and citric acid gel was inserted in the pockets of 3 teeth. And 2 teeth treated in 0.9 % sterile saline served as controls. After 5-minute exposure, each tooth immediately extracted and incubated at room temperature for 22 days in tris-buffered saline as a desorption media. The total volume of TBS was removed and replaced with fresh TBS, at 24-h intervals. Removed desorption media transferred to a sterile vial and stored at -70 oC. This procedure was repeated every 24 h throughout the 22-day desorption period. Using Porphyromonas gingivalis as an indicator organism, a microtiter assay was used to evaluate antimicrobial activity desorbed from the teeth. 1. 50mg/ml tetracycline HCl solution exhibited the longest antimicrobial activity. Compared to saline treated group, it showed significant difference on the day 1 and day 2 desorption period. 2. The ODs of 5% tetracycline gel and a mixture of tetracycline-citric acid gel were significantly different during the first 24 hour only. 3. There was no statistically significant difference after the day 3 between the groups.(p<0.05). Despite our expectation a mixture of tetracycline-citric acid gel did not show longer antimicrobial activities than those of tetracycline gel, and the solution type exhibited the longest activities. Because the gel type agents may stay in the subgingival environment longer than the solution, if the teeth were not extracted immediately after the delivery of the agent, the result could be different. hus this result suggests the possibilities of practical use of these kind of gel type agents.

($CO_2$)레이저 치료에 의한 치근표면의 구조적 변화

김도영,한수부,고재승,박성현,계승범,황광세,김우성,Kim, Do-Young,Han, Soo-Boo,Ko, Jae-Sung,Park, Sung-Hyun,Kye, Seung-Beom,Hwang, Kwang-Se,Kim, Woo-Sung 대한치주과학회 1997 Journal of Periodontal & Implant Science Vol.27 No.3

The purpose of this study was to evaluate the structural change of root surface and the occlusion of dentinal tubule following $CO_2$ laser treatment. Seven extracted healthy human premolar werw curetted, sectioned, and four specimens were randomly assigned to each of 6 different treatment groups : 1) untreated EDTA etched control: 2) root plande only: 3) $CO_2$ laser treated with 2W mode 6(10msec/pulse, 20pps) for 1 minute: 4) $CO_2$ laser treated with 2W mode 6(lOmsec/pulse, 20pps) for 2 minutes: 5) $CO_2$ laser treated with 2W mode 7(20msec/pulse, 20pps) for 1 minute: 6) $CO_2$ laser treated with 2W mode 7(20msec/pulse, 20pps) for 2 minutes. Following the prescribed treatment, the specimens were prepared for SEM evaluation. Results showed that $CO_2$ laser may be effective to occlude dentinal tubules tor dentin sensitivity treatment. The effect of dentinal tubule occlusion was enhanced with increasing the total energy level lased to specimen regardless of lasing mode. The structural changes of root surfaces were restricted to superficies, and these changes included fissuring, charring, crater formation over the smooth lava like texture. The charring and crater formation implying root damage was observed in the case of the longer duration of a pulse. The results of the present study suggests that the pulsed $CO_2$ laser with shorter pulse duration and longer exposure time can be used effectively in order to obtain the optimal dentinal tubule occlusion with minimal root damage.

폐암이 치주 조직에 전이된 증례보고

신지연,한수부,황광세,계승범,Shin, Ji-Yearn,Han, Soo-Boo,Hwang, Kwang-Se,Kye, Seung-Beom 대한치주과학회 1997 Journal of Periodontal & Implant Science Vol.27 No.1

The oral cavity is easily accessible for direct exposure of a malignant disease. 1 percent of the oral malignant tumors are of metastatic origin and approximately 10 percent to 25 percent of the 1 percent fraction originate from the lungs. A case of metastatic lung carcinoma to the gingiva in a 88-year-old male is reported. He complained of pain and swelling between right maxillary 1st premolar and 2nd molar. Although surgical excision of the lesion has been done, the gingival lesion developed as a quickly growing mass and recurred 2 weeks after surgical excision. The gingival mass was histopathologically diagnosed as an undifferentiated carcinoma. Epithelial layer was continuous without ulceration and it seems that the cancer cells are originated from primary tumor. Infiltrated cancer cells were pleomorphic and dyskeratotic. The cells had 2 or more nuclei, not showing squamous or glandular differentiation. Immunohistochemical study revealed the cells originated from the epithelial cells. The prognosis is poor, because prognosis depends on surgical elimination of the primary tumor.

혈소판유래성장인자를 함유한 TCP-chitosan 미세과립이 신생골조직 형성에 미치는 영향에 관한 연구

설양조,이주연,계승범,이영규,김원경,이용무,구영,한수부,이승진,정종평,류인철,Seol, Yang-Jo,Lee, Jue-Yeon,Kye, Seung-Beom,Lee, Young-Kyu,Kim, Won-Kyeong,Lee, Yong-Moo,Ku, Young,Han, Soo-Boo,Lee, Seung-Jin,Chung, Chong-Pyoung,Rhyu, In-C 대한치주과학회 2002 Journal of Periodontal & Implant Science Vol.32 No.3

The purpose of this study was to evaluate newly fabricated tricalcium phosphate(TCP)/chitosan microgranuls as bone substitutes. TCP/chitosan microgranules were fabricated by dropping TCP-chitosan suspension into the NaOH/ethanol solution. The size of microgranules could be controllable via airflow rate. PDGF-BB was loaded into the fabricated granules via freeze-drying methods(300 ng/20 mg). To evaluate cell proliferation, cultured osteoblasts cell lines(MC3T3-El) was dropped on the BioOss(R), chitosan microgranules, TCP/chitosan microgranules and cultured for 1, 7 , 14, and 28 days. Scanning electron microscopic observation was done after 7 days of culture and light microscopic examination was done after 28 days of culture. PDGF-BB release from the microgranules was tested. Rabbit calvarial defects(8 mm in diameter) were formed and chitosan, TCP/chitosan, PDGF-TCP/chitosan microgranules, and BioGran(R) were grafted to test the ability of new bone formation. At SEM view, the size of prepared microgranules was 250-1000 um and TCP powders were observed at the surface of TCP/chitosan microgranules. TCP powders gave roughness to the granules and this might help the attachment of osteoblasts. The pores formed between microgranules might be able to allow new bone ingrowth and vascularization. There were no significant differences in cell number among BioOss(R) and two microgranules at 28 day. Light and scanning electron microscopic examination showed that seeded osteoblastic cells were well attached to TCP/chitosan microgranules and proliferated in a multi-layer. PDGF-BB released from TCP/chitosan microgranules was at therapeutic concentration for at least 1 week. In rabbit calvarial defect models, PDGF-TCP/chitosan microgranules grafted sites showed thicker bone trabeculae pattern and faster bone maturation than others. These results suggested that the TCP/chitosan microgranules showed the potential as bone substitutes.