http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
한봉헌,이헌영,김상용 충남대학교 의과대학 지역사회의학연구소 1982 충남의대잡지 Vol.9 No.1
This 22 years old female has been suffering from dizziness and exertional dyspnea since 2 years ago. She had a massive splenomegaly and one of her brother received splenectomy at 11 years of age. Peripheral blood showed marked pancytopenia and bone marrow smear revealed normocellularity. She received splenectomy, and her clinical features and hematologic findings were progressively improved toward normal.
한봉헌,고석만,윤상룡,노흥규,Han, Bong-Heon,Ko, Suk-Man,Yoon, Sang-Ryong,Ro, Heung-Kyu 대한핵의학회 1980 핵의학 분자영상 Vol.14 No.2
In an attempt to evaluate the diagnostic significance of the serum thyroid hormones in various thyroid function states, the author measured serum $T_3$ uptake, serum $T_3$, serum $T_4$, serum free $T_4$ and free $T_3$ index in 27 cases of normal subjects, 11 cases of hypothyroidism, 152 cases of euthyroidism and 81 cases of hyperthyroidism by the radioimmunoassay method. The results were as follows: 1. The ranges of serum thyroid hormones in normal subjects were, serum $T_3$ uptake; $27.4{\sim}42.1%$, serum $T_3;\;93{\sim}245ng/dl$, serum $T_4;\;4.08{\sim}12.9ug/dl$ and serum free $T_4;\;0.57{\sim}1.53ng/dl(M{\pm}2S.D.)$. 2. Free $T_4$ index and serum $T_4$ show relatively high diagnostic value in euthyroidism group, and serum $T_3\;and\;T_4$ in hypothyroidism group, while serum $T_3$, free $T_4\;and\;T_4$ show relatively high diagnostic value in hyperthyroidism group. 3. There were significant correlation between free $T_4$ index and serum $T_4$(r=0.68), and between free $T_4$ index and serum free $T_4$(r=0.67) in hyperthyroidism group.
Aldosterone 분비에 대한 Dopaminergic Activity에 관한 연구
한봉헌,노흥규 충남대학교 의과대학 지역사회의학연구소 1985 충남의대잡지 Vol.12 No.2
To evaluate the effect of dopaminergic activity on the secretion of aldosterone, the plasma renin activity, serum cortisol and aldosterone levels were measured before and after (15, 30 and 60 min.) the administration of dopamine antagonist, metoclopramide (MC), 15mg i.v. and L-dopa, 500mg p.o., in 6 normal controls and 12 patients who had hyponatremia and generalized edema or ascites with possible secondary aldosteronism, respectively. On the other hand, to confirm the ACTH mediated effect of MC on the aldosterone secretion, the authors measured the same hormones in those subjects who were administered MC after 2mg of dexamthasone administration p.o. to suppress ACTH secretion. The result were as follows: 1. The basal level of PRA was higher in patients rather than control group but PRA was not influenced by MC before and after ACTH suppression or L-dopa adminstration on both control and patient groups. 2. The serum cortisol level was significantly elevated at 30 min after MC injection compared with basal level in control group but no significant change was noted in patient group. After L-dopa admininistration, the serum cortisol level was not changed in both control and patient groups. 3. The serum aldosterone level was significantly elevated in 15, 30 and 60 min. after MC injection in control group and there also same tendency of aldosterone was noticed in patient group. On the other hand, there as no changes in aldosterone level in both control and patient groups with L-dopa administration. 4. After administration of dexamethasone, the serum aldosterone level were noted significant elevation compared with basal level after MC injection in control group and same tendency was noted in patient group. Above result means that MC stimulate aldosterone secretion by dopaminergic antagonist with partially ACTH mediated effect and aldosterone secretion in normal subjects is under the condition of maximal tonic dopaminergic inhibition.
각종 갑상선 질환에서 혈청 Thyroxine 결합글로부린 (TBG) 의 진단적 의의
노흥규,한봉헌,이헌영,고석만,윤상룡 대한핵의학회 1981 핵의학 분자영상 Vol.15 No.2
In an attempt to evaluate the diagnostic significance of the serum thyroxine binding globulin(TBG) in various thyroid disease states, the authors measured serum T3 uptake, T3, total T4, free T4, TSH and TBG by radioimmunoassay technique, and calculated the free T4 index(FT4I) and T4/TBG ratio in 10 cases of normal subjects, 11 eases of hypothyroidism, 62 cases of euthyroidism and 37 cases of hyperthyroidism. The data were analysed in the aspects of diagnostic significance in each thyroid disease state, and the results were as follows; 1) In 10 cases of normal subjects, serum TBG was 17.4∼26.8ug/ml, FT4I was 5.1∼9.7, and T4/TBG ratio was 21.9∼49.9(Mean±S.D.). 2) 62 cases of euthyroidism with diffuse and nodular goiter, FT4I was 7.26±1.82, T4/TBG ratio was 31.47±10.42, and there were no significant difference from those of normal subjects(p〉0.5). 3) In 11 cases of hypothyroidism, the FT4I was 3.13±2.15, T4/TBG ratio was 11.3±5.31, significantly lower than normal controls(p〈0.01). 4) In 37 cases of hypsm, the FT4I was 30.0±12.01 T4/TBG ratio was 121.4±62.2, significantly higher than normal controls(p〈0.01). 5) There were significant correlations between the FT4I and T4/TBG ratio, total T4 and T4/TBG radio, in each thyroid function states. 6) The FT4I showed 100% of diagnostic value in hyperthyroidism, 89.2% in euthyroidism, and 80% in hypothyroidism group. The T4/TBG ratio showed 100% of diagnostic value in hyperthyroidism and hypothyroidism, and 80.6% in euthyroidism group. The above results suggest that T4/TBG ratio and FT4I showed same diagnostic value in hyperthyroidism group, but T4/TBG showed higher diagnostic significance than FT4I in hypothyroidism.
Dopaminergic Activity 가 부종상태에서 혈청 Aldosterone 분비에 미치는 영향
노흥규,한봉헌 대한핵의학회 1985 핵의학 분자영상 Vol.19 No.2
To evaluate the effect of dopaminergic activity on aldosterone secretion, the plasma renin activity, serum cortisol and aldosterone were measured by radioimmunoassay in 6 normal controls and 12 patients who had hyponatrernia and generalized edema or ascites with possible condition with secondary aldosteronism before and after(l5,30, and 60 min) 15mg of metoclopramide by iv bolus injection and same method with 500mg of L-dopa by per oral in 6 normal controls and 12 patients with edema ascites. The result were as follows; l) The basal level of PRA was higher in patients rather than norrnal controls but PRA was not influenced by MC or L-dopa adrninistration on both normal controls and patients group. 2) The serum cortisol level was significantly elevated at 30 min after MC injection compared with basal level in normal controls but no significant change was not patients group. After L-dopa administration the serum cortisol level was noted in changed in both normal controls and patients group, 3) The serum aldosterone level was significantly elevated in 15,30 and 60 min after MC injaction in normal controls, and there also same tendency of aldosterone secretion was noticed in patients group. On the other hands, there was no changes in aldosterone level in both normal controls and patients group with L-dopa administration. Above result means that MC stimulate aldosterone secretion by dopaminergic antagonist and aldoaterone secretion in normal subject is controlled by maximaI tonic dopaminergic inbibition. In edematous patients, however, both of the dopaminergic inhibitory and stimulating effect of PRA, ACTH etc o#n the aldosterone secretion seems to be variable.
각종 갑상선질환에서 혈청 Thyroglobulin 치에 관한 연구
이복희,노흥규,김창국,한봉헌,전병숙 대한핵의학회 1983 핵의학 분자영상 Vol.17 No.1
In an attempt to evaluate the diagnostic significance of the serum thyroglobulin (TG) in various thyroid disease states, authors measured serum TG by radioimmunoassay techniqe in 20 cases of normal subject, 22 cases of hyperthyroidism, 12 cases of diffuse nontoxic goiter (DNG) and 96 Gases of nodular nontoxic goiter (NNG). The results were as follows; 1) In 20 cases of normal subjects, serum TG level was 20.41±5.5 ng/ml (M±S.D.). There was no significant difference between males ans females. 2) In 22 cases of hyperthyroidism, serum TG level was 60.23±34.56 ng/ml and the range was from 22 to 175 ng/ml, which were significantly high levels comparing with normal controls (p〈0.01). 3) In 12 cases of euthyroidism with DNG, serum TG was 37.28±27.36 ng/ml and the range was from 14 to 89 ng/ml. In 96 cases of euthyroidism with NNG, serum TG was 70.43±78.18 ng/ml and the range was from 12.8 to 440 ng/ml. Both various showed significantly increased levels of TG than normal control (p〈0.01). 4) 57 cases of NNG pawere analysed pathologically by operation or needle biopsy and the TG level of each disease group is as follows. Thyroid carcinoma (l6 cases); 72.2±81.71 ng/ml, adenomatous goiter without cystic degeneration (15 cases); 74.86±45.64 ng/ml (M±S.D.) and adenomatous goiter with cystic degeneration (23 cases); 73.56±64.78 ng/ml (M±S.D.). There was no significant difference between each group. Also the TG levels of thyroiditis (5 cases) was 19.6±8.96 ng/ml (M±S.D.). 5) There were no significant correlations between serum thyroid hormones and serum TG in each thyroid functional states.