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고지방식이 비만마우스 모델에서 파키스탄산 및 중국산 마황으로 조성된 강지환(降脂丸)-1, 2, 3, 4와 강지환(降脂丸)-1합가미소체환(合加味消滯丸)의 체중감량효과 비교
유재상 ( Jae Sang Yoo ),구자룡 ( Ja Ryong Ku ),윤기현 ( Ki Hyeon Yoon ),조주흠 ( Ju Heum Jo ),장두현 ( Du Hyon Jang ),정양삼 ( Yang Sam Jung ),김종훈 ( Jong Hoon Kim ),김병출 ( Byeong Chul Kim ),석화준 ( Hoa Jun Seok ),윤미정 ( Mi 한방비만학회 2015 한방비만학회지 Vol.15 No.1
Objectives: This study was investigated the improvement effects of Pakistani Ephedra herba- containing Gangji-hwan-1, 2, 3 (Di-fatty; DF-1, 2, 3), Chinese Ephedra herba-containing Gangji- hwan-4 (DF-4) and combination of DF-1 and Gamisoche-hwan (GSH) on obesity in a high fat diet-fed obese mouse model.Methods: Eight-week-old C57BL/6N mice were divided into seven groups: a normal lean group given a standard diet, an obese control group given a high fat diet, and DF-1, 2, 3, 4, and DF-1+GSH groups given a high fat diet with DF-1, 2, 3, 4 (40, 80, 160, 80 mg/kg), and DF-1+ GSH (80 mg/kg), respectively. After 8 weeks of treatment, body weight gain, feeding efficiency ratio (FER), blood lipid markers, liver histology, and fat weight and histology were examined. Results: Body weight gain was significantly decreased in DF and DF-1+GSH groups compared with control. The extent of decreases was eminent in DF-1+GSH group. FER and circulating concentration of leptin were decreased in DF and DF-1+GSH groups compared with control. Circulating concentrations of triglyceride, glucose and insulin were decreased in DF and DF-1+GSH groups compared with control. The size of adipocytes were decreased by DF and DF-1+GSH groups compared with control, whereas the adipocyte number per unit area was increased by them, suggesting that DF and DF-1+GSH groups decreased the number of large adipocytes. Conclusions: In conclusion, these results suggest that DF and DF-1+GSH groups decrease FER, plasma leptin concentration, blood anti-obesity biomarkers and fat mass, improves body weight gain. In addition, these effects were more effective in DF-1+GSH combination group than in DF-1, 2, 3, 4 groups.
고지방식이 비만마우스 모델에서 파키스탄산 마황으로 조성된 강지환(降脂丸)의 단독 투여와 강지환합가미소체환(降脂丸合加味消滯丸)의 병용 투여의 체중감량 효과 비교
석화준,유재상,구자룡,윤기현,조주흠,장두현,정양삼,김종훈,김병출,노종성,이혜림,이형희,윤미정,신순식,Seok, Hoa Jun,Yoo, Jae Sang,Ku, Ja Ryong,Yoon, Ki Hyeon,Jo, Ju Heum,Jang, Du Hyon,Jung, Yang Sam,Kim, Jong Hoon,Kim, Byeong Chul,Roh, Jong Seong 대한한의학방제학회 2014 大韓韓醫學方劑學會誌 Vol.22 No.2
Objectives : This study was investigated the improvement effects of Gangjihwan (DF) and combination of Gangjihwan and Gamisochehwan (GSH) on obesity in a high fat diet-fed obese mouse model. Methods : Eight-week-old C57BL/6N mice were divided into four groups: a normal lean group given a standard diet, an obese control group given a high fat diet, and DF and DF+GSH groups given a high fat diet with DF (40 mg/kg), and DF+GSH (80 mg/kg), respectively. After 8 weeks of treatment, body weight gain, feeding efficiency ratio, blood lipid markers, fat weight and histology were examined. Results : 1. Body weight gain and fat mass were significantly decreased in DF and DF+GSH groups compared with control. The extent of decreases was eminent in DF+GSH group. 2. Feeding efficiency ratio and circulating concentration of leptin were decreased in DF and DF+GSH groups compared with control. These decreases were significant in DF+GSH group. 3. Consistent with their effects on body weight gain and fat mass, circulating concentrations of triglyceride, glucose and insulin were decreased in DF and DF+GSH groups compared with control. 4. The size of adipocytes was decreased by DF and DF+GSH compared with control, whereas the adipocyte number per unit area was increased by them, suggesting that DF and DF+GSH decreased the number of large adipocytes. 5. Consistent with their effects on body weight gain, liver fibrosis was also improved in DF and DF+GSH groups compared with control. Conclusions : In conclusion, these results suggest that DF and DF+GSH groups decrease feeding efficiency ratio, plasma leptin concentration, blood anti-obesity biomarkers and fat mass, improves body weight gain contributing to the inhibition of liver fibrosis. In addition, these effects were more effective in DF+GSH combination group than in DF-only group.
고지방식이 비만마우스 모델에서 파키스탄산 및 중국산 마황으로 조성된 강지환(降脂丸)의 체중감량 효과 비교
김병출,석화준,유재상,구자룡,윤기현,조주흠,장두현,정양삼,김종훈,안예지,우상이,윤미소,신순식,Kim, Byeong Chul,Seok, Hoa Jun,Yoo, Jae Sang,Ku, Ja Ryong,Yoon, Ki Hyeon,Jo, Ju Heum,Jang, Du Hyon,Jung, Yang Sam,Kim, Jong Hoon,Ahn, Ye Ji,Woo, San 대한한의학방제학회 2014 大韓韓醫學方劑學會誌 Vol.22 No.2
Objectives : This study investigated the improvement effects of Pakistani (DF-a) and Chinese Ephedra herba-containing Gangjihwan (DF-b) on obesity in a high fat diet-fed obese mouse model. Methods : Eight-week-old C57BL/6N mice were divided into four groups: a normal lean group given a standard diet, an obese control group given a high fat diet, and DF-a and DF-b groups given a high fat diet with DF-a (80 mg/kg), and DF-b (80 mg/kg), respectively. After 8 weeks of treatment, body weight gain, feeding efficiency ratio, blood lipid markers, fat weight and histology were examined. Results : 1. Body weight gain and fat mass were significantly decreased in DF-a and DF-b groups compared with control. The extent of decreases was eminent in DF-a group. 2. Feeding efficiency ratio and circulating leptin concentration were significantly decreased in DF-a and DF-b groups compared with control, whereas circulating adiponectin concentration was increased in DF-a and DF-b groups compared with control. 3. Consistent with their effects on body weight gain and fat mass, circulating concentrations of triglyceride, glucose and insulin were decreased in DF-a and DF-b groups compared with control. 4. The size of adipocytes were decreased by DF-a and DF-b compared with control, whereas the adipocyte number per unit area was increased by them, suggesting that DF-a and DF-b decreased the number of large adipocytes. 5. Consistent with their effects on body weight gain, liver fibrosis was reduced in DF-a and DF-b groups compared with control. Conclusions : In conclusion, these results suggest that DF-a and DF-b not only decrease feeding efficiency ratio, plasma leptin concentration, and blood anti-obesity biomarkers, but also reduce fat mass, contributing to the improvement of obesity. DF-a and DF-b also inhibit liver fibrosis. In addition, these effects were similar between Pakistani Ephedra herba and Chinese Ephedra herba-containing Gangjihwan.
저출산고령화시대에 있어서의 사회보장제도의 현황과 과제 ~ 일본사회보장제도의 변천이 시사하는 교훈 ~
이와타준 ( Iwata Jun ),유재상 ( Yoo Jae-sang ) 한국일어일문학회 2021 日語日文學硏究 Vol.117 No.-
본 연구는 소자고령화가 진행되고 있는 일본의 사회보장제도의 현황과 과제를 검토하고 한국사회에 시사하는 교훈을 정리해서 사회보장제도와 정책에 대한 제안과 방향제시를 목적으로 하고 있다. 한국과 일본은 앞으로도 계속해서 인구가 감소하고 단신세대의 비율이 증가하는 등 공통점이 많다. 특히, 켄죠(2009)가 제시한 복지국가3유형중에서 한국과 일본은 “가족의존형”으로 분류되며 일본사회가 경험해온 시행착오는 가까운 장래에 한국사회와 경험할 가능성이 크다. 본 논문은 일본사회보장제도의 변천과정을 개관하고 최근의 경제상황과 국채발행 및 채무구조, 사회보장급부의 현황을 고찰함과 동시에 일본의 연금제도와 건강보험 및 개호보험의 현황과 과제등에 대한 검토를 통해서 한국사회보장제도에 대한 정책제안과 방향성을 제시하고 있다. In this paper, we will give an overview of the changes in Japan's social security system and understand the current state of Japan's economic growth, debt, and social security benefits. Then, after considering the introduction process, system, and issues of the Japanese pension, medical, and long-term care insurance system, the further declining birthrate and aging population and future issues will be described. also gave five specific lessons that the transition of Japan's social security system. Japan’s system can also be studied in order to improve the direction of South Korea's social security system. Comparing the future forecasts of Japan and South Korea, there are many things in common between Japan and South Korea, such as a declining population and an increase in the proportion of single-person households. The three types of family-dependent (Japanese type) of the welfare state shown by Kenjo (2009) are considered to be classified not only in Japan but also in South Korea. The changes in socio-economic conditions that Japanese society has experienced after the war are expected to occur in South Korea in the near future.