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자가 면역성 갑상선 질환에서 체액성 면역 기능에 관한 연구
전병숙(Byung Sook Jeon),장준(Joon Jang),성기양(Ki Yang Sung),안정기(Jeong Ki Ahn),이경숙(Kyung Suk Lee),김삼용(Sam Yong Kim),노흥규(Heung Kyu Ro) 대한내과학회 1991 대한내과학회지 Vol.40 No.3
N/A To investigate the lymphocyte function in humoral immunity in autoimmune thyroid disease, serum levels of IgG, IgA, TBII, and in vitro production of IgG, IgA with or without pokeweed mitogen (PWM) stimulation were measured in 17 patients with untreated Graves' disease, 15 patients with Graves' disease in remission, 12 patients with Hashimoto's thyroiditis, and 8 normal controls. The results were as follows: 1) The levels of in vitro production of IgG in untreated Graves' disease (2767.1±725.8 ng/ml), Graves disease in remission (5982.3±1268.9 ng/ml), and Hashimoto's thyroiditis (6898.4±2434.0 ng/ml) were significantly higher than those of the normal controls (438.6±57.9 ng/ ml) (p<0.05). 2) In vitro production of IgG with PWM in untreated Graves' disease (2162.5±649.3 ng/ml) was significantly lower than the normal controls. 3) In vitro production of IgA was not different between each disease group and normal controls. 4) In vitro production of IgA with PWM in untreated Graves's disease (2162.5±649.3 ng/ml) was significantly lower than the normal controls (8422.9±2599.2 ng/ml) (p<0.05), but production those patients with Graves' disease in remission and patients with Hashimoto's thyroiditis was not different from the controls. 5) The stimulation index of IgG in patient of untreated Graves' disease (4.3± 1.3), Graves' disease in remission (8.3±2.7), and Hashimoto's thyroiditis (4.8±2.0) was significantly lower compared with that of the normal controls (49.1±8.9) (p <0.01). But significant difference was not noted between untreated Gravers' disease and Graves' disease in remission the stimulation index for IgA was different only between untreated Graves disease patients and the control groups; 2.4±0.5 versus 8.4±2.2 (p < 0.05). 6) Serum TBII showed no correlation with in vitro IgG levels of untreated patients with Graves' disease or patients with Graves' disease in remission. 7) There was no correlation between serum IgG and in vitro IgG, production not between serum IgA and in the vitro IgA production. The above results indicate that there is a defect in humoral immunity in patients with autoimmune thyroid disease, and the function of immunoglobulin production becomes normalized partially according to the remission of the disease.
노흥규,전병숙 충남대학교 의과대학 지역사회의학연구소 1982 충남의대잡지 Vol.9 No.2
To evaluate the diagnostic significance of thyroid autoantibodies in chronic lymphocytic thyroiditis, the serum anti-thyroglobulin antibody and anti-microsomal antibody were detected in 48 cases of chronic lymphocytic thyroiditis by RIA and TRC agglutination method, and compared with those of Graves' disease, simple goiter, thyroid cancer and adenomatous goiter treated at the Dept. of Internal Medicine, CNUH, since Oct. 1981 till Nov. 1982. The results were as follows: 1. The serum TG-Ab was positive in 47.9% of chronic thyroiditis, 40% in Graves' disease and 5.3% in simple goiter, whereas the serum MC-Ab was positive in 84.6% in Graves' disease and 77.1 % in chronic thyroiditis. 2. In 82.9% of 35 cases of chronic thyroiditis, any one of both TG-Ab or MC-Ab was positive. 3. Hypothyroidism were more prevalent in those cases whose antibodies were positive in both two, while euthyroidism in MC-Ab positive only.
각종 갑상선질환에서 혈청 Thyroglobulin 치에 관한 연구
이복희,노흥규,김창국,한봉헌,전병숙 대한핵의학회 1983 핵의학 분자영상 Vol.17 No.1
In an attempt to evaluate the diagnostic significance of the serum thyroglobulin (TG) in various thyroid disease states, authors measured serum TG by radioimmunoassay techniqe in 20 cases of normal subject, 22 cases of hyperthyroidism, 12 cases of diffuse nontoxic goiter (DNG) and 96 Gases of nodular nontoxic goiter (NNG). The results were as follows; 1) In 20 cases of normal subjects, serum TG level was 20.41±5.5 ng/ml (M±S.D.). There was no significant difference between males ans females. 2) In 22 cases of hyperthyroidism, serum TG level was 60.23±34.56 ng/ml and the range was from 22 to 175 ng/ml, which were significantly high levels comparing with normal controls (p〈0.01). 3) In 12 cases of euthyroidism with DNG, serum TG was 37.28±27.36 ng/ml and the range was from 14 to 89 ng/ml. In 96 cases of euthyroidism with NNG, serum TG was 70.43±78.18 ng/ml and the range was from 12.8 to 440 ng/ml. Both various showed significantly increased levels of TG than normal control (p〈0.01). 4) 57 cases of NNG pawere analysed pathologically by operation or needle biopsy and the TG level of each disease group is as follows. Thyroid carcinoma (l6 cases); 72.2±81.71 ng/ml, adenomatous goiter without cystic degeneration (15 cases); 74.86±45.64 ng/ml (M±S.D.) and adenomatous goiter with cystic degeneration (23 cases); 73.56±64.78 ng/ml (M±S.D.). There was no significant difference between each group. Also the TG levels of thyroiditis (5 cases) was 19.6±8.96 ng/ml (M±S.D.). 5) There were no significant correlations between serum thyroid hormones and serum TG in each thyroid functional states.
박해근,김광진,성혜숙,전병숙,Park, Hae-Kun,Kim, Kwang-Jin,Sung, Hae-Sook,Jeon, Byung-Sook 대한생리학회 1977 대한생리학회지 Vol.11 No.2
The maximum voluntary ventilation (MVV) is one of the most widely used pulmonary function test, but its measuring method was very difficult and unreliable. However, it is need to get more easy and simple measuring method of MVV. Therefore, this study was attempted to get more easy and simple measuring method of MVV by means of the forced expiratory volume $(FEV_{T})$. The young and healthy 1,000 Korean students(592 male and 408 female) were cheesed for this purpose and whose ages were from 8 to 20 years. A spirometer (9L, Collins Co.) was used for the MVV and FEV, and they were measured 3 times at standing position, and the highest value was used. In the measurements, the subjects for MVV were asked for the breath as fast and deeply as possible for 12 seconds, and for FEV were asked for the rapid and forceful exhalation after a maximal inhalation (forced expiratory curve). In the FEV measurements toward the end of the expiration, the subjects were exhaused to continue the effort until no further gas was expired. During these measurements, the investigator stood by the subject to give a constant encouragement. FEV were calculated in the volume exhaled during the one-half $(FEV_{0{\cdot}5,}\;ml)$, the first second $(FEV_{1{\cdot}0,}\;ml)$ and the percentage of the total vital capacity exhaled during the one-half second $(FEV_{0{\cdot}5,}\;%)$. The results are summarized as follows: 1) The values of MVV were increased linearly with ages until 20 in both sexes. The values of male at the age of 20 was $168.2{\pm}2.5L/min$, and female at the age of 17 was $112.3{\pm}3.0L/min$, respectively. 2) The values of FEV (ml) were increased linearly with ages until 20 in both sexes. The values of $FEV_{0{\cdot}5}$ were $2,797{\pm}65.7ml$ in the male of 20 years and were $2,088{\pm}54.6ml$ in the female of 17 years, and of $FEV_{1{\cdot}0$ were $4,119{\pm}68.2ml$ in the male of 20 years and were $2,897{\pm}65.9ml$ in the female of 17 years, respectively. 3) The correlation coefficients between MVV and $FEV_{0{\cdot}5}\;or\;FEV_{1{\cdot}0$ (ml) were 0.82 or 0.85 in the male, and 0.77 or 0.79 in the female, respectively. 4) The prediction formulae for MVV to be derived from above results were: For male: MVV (L/min) =7.19+$0.05{\times}FEV_{0\cdot5}(ml)$, MVV (L/min)=11.25+$0.04{\times}FEV_{1\cdot0}(ml)$ For female: MVV (L/min)=16.03+$0.05{\times}FEV_{0\cdot5}(ml)$, MVV (L/min)=9.47+$0.03{\times}FEV_{1\cdot0}(ml)$.