http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
상염색체우성 다낭신에서 질병진행 예측인자로서 요중 안지오텐시노겐의 유용성
박혜인조 ( Hayne Cho Park ),황진호 ( Jin Ho Hwang ),백선하 ( Seon Ha Baek ),한미연 ( Mi Yeun Han ),윤유경 ( Yu Kyoung Yun ),윤명옥 ( Myeong Ok Yoon ),오국환 ( Kook Hwan Oh ),구자룡 ( Ja Ryong Koo ),김형직 ( Hyung Jik Kim ),노정우 ( 대한신장학회 2011 Kidney Research and Clinical Practice Vol.30 No.5
Purpose: The renin-angiotensin-aldosterone system activation has been suggested as a potential risk factor for renal progression in autosomal dominant polycystic kidney disease (ADPKD). This study was performed to evaluate urinary angiotensinogen as a biomarker of renal progression in ADPKD. Methods: Patients with estimated glomerular filtration rate (eGFR) 30 mL/min/1.73m≥2 were enrolled in the study. Specimens (blood and urine) and computed tomography (CT) were taken from each subject. The eGFR was calculated by 4-variable MDRD equation and total kidney volume (TKV) was measured from CT images by modified ellipsoid method. Urinary angiotensinogen (AGT) and neutrophil gelatinaseassociated lipocalin (NGAL) were measured by ELISA. The concentration of AGT was adjusted with random urine creatinine (Cr). The association between urinary biomarkers, TKV and eGFR were evaluated. Results: A total of 59 (M:F=31:28) subjects were enrolled in the study and their mean age was 46 years. The eGFR and TKV at the enrollment were 77.3±15.6 mL/min/1.73m2 and 1389.8±925.1 mL, respectively. Log AGT/Cr was associated with TKV (r2=0.11p=0.01) in the earlier stage of disease (TKV<000 mL). However, it did not show significant correlation with eGFR. Log NGAL was not associated with either TKV or eGFR. Urinary AGT/Cr was closely related to the number of anti-hypertensive medication, TKV, and the presence of albuminuria, although there was no correlation with plasma renin activity or aldosterone level. Conclusion: Urinary angiotensinogen may be a useful biomarker of disease progression in ADPKD patients.
이정금(Lee Jung-Geum),김영란(Kim Young-Rhan),강효정(Kang Hyo-Jung),한미라(Han Mi-Ra),임부연(Lim Boo-Yeun) 한국열린유아교육학회 2007 열린유아교육연구 Vol.12 No.1
본 연구는 유아들이 산책활동을 통해 가지게 되는 독특한 경험양식을 주의 깊은 관찰과 경청을 통해 질적으로 연구해보는 것을 목적으로 하였다. 산책활동이 일상적인 생활로 이루어지는 두 유아교육기관 만5세 유아를 대상으로 비디오 촬영과 연구일지로 자료를 수집하였다. 본 연구에서 산책활동 경험은 그동안 현대 유아교육에서 간과 해온 자연의 의미와 중요성을 다시 생각하게 하는 기회를 제공하였으며, 특히 유아들은 자연과 만나면서 그들의 몸과 마음을 매우 특별하고 창의적인 방법으로 활용하고 확장하는 능력을 보여주었다. 산책활동을 통해 유아들이 구조화된 실내외 교실에서 경험할 수 없는 독특한 몸의 감각과 인지작용을 가능하게 함으로써 보다 높은 단계로 나아가는 학습능력 그리고 자연적 능력과 사회적 능력을 동시에 보여 주었다. 이러한 점에서 본 연구는 자연이 주요한 교육적 화두로 등장하는 오늘날 유아교육기관에서 유아의 풍부한 경험세계를 확장하는 좋은 활동의 예로써 산책활동에 보다 귀 기울이고 적극적으로 활용할 것을 제안하였다. This study aims at looking closely young children's experiential world observed through San-Check, a walking activity in nature. The researcher particularly focused on how young children build experiences in nature which are totally different from their structured classroom, and their competence in dealing with many stimuli and materials found in nature. Two classes of five-year-olds which do a walking activity on a daily basis were selected. Data were collected from direct observation of children's walking activity from June 2006 to September 2006. The researcher went to each school at least once a week to participate in the walking activity which lasted 2-3 hours or almost a half day before lunch time. The study revealed that young children construct their experiences in very creative and unique ways and are extremely competent in using their bodies and thoughts in nature. Children demonstrated a striking ability to use their bodies through their sensory organs and became more sensitive and intellectual. Children also displayed diverse ways of thinking ways that are more creative, alive and intellectual than those demonstrated in structured classrooms. Children's thinking skills became more imaginative, explorative, and sympathetic towards wildlife. This study suggests that a walking activity in an early childhood institution should be viewed as an educational activity that helps young children use their somatic senses in more intellectual ways. This study suggests that a walking activity like San-Check should be more actively considered to help young children's experience become more healthy, spiritual, and intellectual.