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베체트 환자에서의 monocyte chemoattractant protein-1의 상승
도주호 ( Do Ju Ho ),정지현 ( Jeong Ji Hyeon ),박찬석 ( Park Chan Seog ),고지송 ( Go Ji Song ),김순섭 ( Kim Sun Seob ),최현철 ( Choe Hyeon Cheol ),손장명 ( Son Jang Myeong ),민도준 ( Min Do Jun ),박성환 ( Park Seong Hwan ),조철수 ( 대한내과학회 2003 대한내과학회지 Vol.65 No.4
목적: 베체트병에서는 림프구, 단핵구, 호중구에 의한 염증성 혈관염이 흔하게 발생하는데 특히 단핵구의 활성화와 충원을 책임지는 MCP-1과 같은 케모카인의 증가가 조직 내 염증세포의 충원과 침윤에서 중요한 역할을 할 것으로 생각되나 아직까지 이에 대한 연구는 없는 실정이다. 저자들은 본 연구에서 베체트병 환자의 혈청 혹은 세포배양액에서 MCP-1의 표현을 조사하고 RANTES, MIP-1α IL-8 등 다른 케모카인들과의 연관성을 조사하였다. 방법: 7 Background: Monocyte chemoattractant protein-1 (MCP-1) belongs to C-C subfamily of chemokines, which stimulates the migration of monocytes. MCP-1 exerts various effects on the monocytes, including the induction of integrin and tissue factor, and synthesis
이정록 ( Lee Jeong Log ),신영신 ( Sin Yeong Sin ),이승우 ( Lee Seung U ),최현철 ( Choe Hyeon Cheol ),김형욱 ( Kim Hyeong Ug ),박철휘 ( Park Cheol Hwi ),최영진 ( Choe Yeong Jin ),장윤식 ( Jang Yun Sig ),방병기 ( Bang Byeong Gi ) 대한신장학회 2003 Kidney Research and Clinical Practice Vol.22 No.6
A 33-year-old man was admitted with macroscopic hematuria and systemic edema appearing after an acute upper respiratory tract infection. On admission, hypertension, nephrotic syndrome were evident together with a decreased renal function. Renal biopsy showed markedly increased mesangial cells acompanied with increase of endocapillary cells including neutrophils. Immunofluorescence microscopy showed granular deposits of C3 and IgA. Electron Microscopy revealed so-called hump on the subepithelial area. These features were consistent with the coexistence of IgA nephropathy (IgAN) and post-infections glomerulonephritis. It is not clear about the prognosis and the therapeutic regimen in the patient who develop above situation. Although the patient showed still persistent proteinuria, high dose steroid therapy was probably useful for improving the disease. (Korean J Nephrol 2003;22(6):773-776)