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Nicotine이 배양된 정상 인체 멜라닌세포의 멜라닌화에 미치는 영향
최천필,김영일,이진우,이무형 경희대학교 동서의학연구소 2006 東西醫學硏究所 論文集 Vol.2006 No.-
Nicotine, the active ingredient of tobacco, causes increased platelet aggregation, endothelial cell damage and alterations in prostacyclin and thromboxane metabolism. Skin changes with nicotine include brown pigmentary staining of hands and nails, leg ulcers, cyanosis, decreased skin temperature and other signs of arterial insufficiency. However, the effect of nicotine on melanization is not well established. The purpose of this study is to evaluate the effect of nicotine on melanization in cultured normal human melanocytes. In order to evaluate non-cytotoxic dose of nicotine, we exposed various concentrations (0.01, 0.1, 1, 10, 100, and 1000 μg/ml) of nicotine to melanocytes and examined cell cytotoxicity using MTT assay. There was no cytotoxicity below 0.1 μg/ml of nicotine. After exposure to 0.1μg/ml nicotine on cultured normal human melanocytes, we investigated the effects of nicotine on the expression of tyrosinase (TYR), tyrosinase-related protein 1 (TYRP1), DOPAchrome tautomerase (DCT) at the protein levels in human skin melanocytes. There was no significant difference in the expression of TYR, TYRP1, and DCT protein after treatment with nicotine compared to the untreated control. These results suggest that short-term nicotine exposure had no direct melanogenic effect, in vitro.
최천필,이무형 대한의진균학회 2006 대한의진균학회지 Vol.11 No.1
Tinea capitis is a fungal infection of the scalp and hair. It is very common in children and unusual in adults. We evaluated the clinical and mycologic aspects of tinea capitis in 6 adult patients registered in Kyunghee University Hospital from January 2003 to December 2003. The isolated dermatophytic flora of the patients consisted of Trichophyton rubrum (83%) and Microsporum canis (17%). When tinea capitis occurs in adults the clinical features may be atypical and this may delay the diagnosis. The necessity for heightened clinical suspicion and diagnostic tenacity in the evaluation of adults with scalp dermatitis and/or alopecia for possible tinea capitis is underscored.
Trichophyton mentagrophytes에 의한 두부독창 1예
최천필,이무형,허충림 대한의진균학회 2004 대한의진균학회지 Vol.9 No.4
Kerion celsi is a highly inflammatory, supprative fungal infection of the scalp caused mainly by zoophilic dermatophytes transmitted from animals to man. We report a case of kerion celsi caused by Trichophyton(T.) mentagrophytes in 9 year-old male, who showed 10 × 9 cm and 2 × 1 cm sized, markedly inflammatory, boggy masses on the scalp and erythematous scaly patch on the philtrum. Cultures from a scalp lesion of the patient on Sabouraud glucose agar showed T. mentagrophytes. Treatment was done systemically with steroid and antifungal agents.