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최주환,양제파,이진환,이준희,김현구,용환석,이승룡 대한암학회 2022 Cancer Research and Treatment Vol.54 No.3
Purpose The usefulness of rehabilitation in patients with reduced lung function before lung surgery remains unclear, and there is no adequate method for evaluating the effect of rehabilitation. We aimed to evaluate the usefulness of rehabilitation in patients with non-small cell lung cancer (NSCLC) undergoing lung cancer surgery.Materials and Methods We retrospectively analyzed the medical records of NSCLC patients at Korea University Guro Hospital between 2018 and 2020. Patients were divided into two groups depending on whether they underwent rehabilitation. Pulmonary function test (PFT) data and muscle determined using chest computed tomography (CT) images were analyzed. Because the baseline characteristics were different between the two groups, propensity score matching was performed.Results Of 325 patients, 75 (23.1%) and 250 (76.9%) were included in the rehabilitation and non-rehabilitation (control) groups, respectively. The rehabilitation group had a worse general condition at baseline. After propensity score matching, 45 patients remained in each group. Pulmonary function (forced expiratory volume in 1 second, %) (p=0.001) and the Hounsfield unit of erector spinae muscle (p=0.001) were better preserved in the rehabilitation group. Muscle loss of 3.4% and 0.6% was observed in the control and rehabilitation groups, respectively (p=0.003). In addition, the incidence of embolic events was lower in the rehabilitation group (p=0.044).Conclusion Pulmonary rehabilitation is useful in patients with NSCLC undergoing lung surgery. Pulmonary rehabilitation preserves lung function, muscle and reduces embolic events after surgery. Pulmonary rehabilitation is recommended for patients with NSCLC undergoing surgery.
최주환,오지연,이영석,허규영,이승룡,심재정,강경호,민경훈 연세대학교의과대학 2019 Yonsei medical journal Vol.60 No.2
Purpose: The most common cause of acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is respiratory infection. Most studies of bacterial or viral cause in AECOPD have been conducted in Western countries. We investigated bacterialand viral identification rates in AECOPD in Korea. Materials and Methods: We reviewed and analyzed medical records of 736 cases of AECOPD at the Korea University Guro Hospital. We analyzed bacterial and viral identification rates and classified infections according to epidemiological factors, such asGlobal Initiative for Chronic Obstructive Lung Disease stage, mortality, and seasonal variation. Results: The numbers of AECOPD events involving only bacterial identification, only viral identification, bacterial-viral co-identification,and no identification were 200 (27.2%), 159 (21.6%), 107 (14.5%), and 270 (36.7%), respectively. The most common infectiousbacteria identified were Pseudomonas aeruginosa (13.0%), Streptococcus pneumoniae (11.4%), and Haemophilus influenzae(5.3%); the most common viruses identified were influenza virus (12.4%), rhinovirus (9.4%), parainfluenza virus (5.2%), andmetapneumovirus (4.9%). The bacterial identification rate tended to be higher at more advanced stages of chronic obstructivepulmonary disease (p=0.020 overall, p=0.011 for P. aeruginosa, p=0.048 for S. pneumoniae). Staphylococcus aureus and Klebsiellapneumoniae were identified more in mortality group (p=0.003 for S. aureus, p=0.009 for K. pneumoniae). All viruses were seasonal(i.e., greater prevalence in a particular season; p<0.050). Influenza virus and rhinovirus were mainly identified in the winter,parainfluenza virus in the summer, and metapneumovirus in the spring. Conclusion: This information on the epidemiology of respiratory infections in AECOPD will improve the management of AECOPDusing antibiotics and other treatments in Korea.
최주환,최종현,이영석,오지연,민경훈,허규영,이승룡,심재정,강경호 대한결핵 및 호흡기학회 2017 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.124 No.-
Nivolumab, a human programmed death 1(PD-1) immune checkpoint inhibitor antibody has been approved in Korea for the treatment of advanced NSCLC after platinum-based chemotherapy. Nivolumab has demonstrated longer overall survival than docetaxel among the previously treated NSCLC patients. We have assessed the safety of nivolumab in 8 patients who were enrolled in the NSCLC Expanded Access Program (EAP) in Korea University Guro Hospital(KUGH). Subjects with NSCLC who have relapsed after a minimum of 1 prior systemic treatment for stage IIIB/stage IV disease were included. Subjects were treated with 3 mg/kg of nivolumab IV every 2 weeks for a maximum of 24 months with 14-day dosing period in each cycle. Patients received ≥ 1 dose of nivolumab and were monitored for adverse events using NCI Common Toxicity Criteria(Version 4.0). As of June 30, 2017, 8 NSCLC patients participated in the EAP from KUGH and received nivolumab. All participants were male. Except for 1(12.5%) current smoker and 1(12.5%) never smoker, other 6(75%) patients were former smokers. The average of smoking period was 27 pack-years. 2 had squamous and 6 had non-squamous histology. At the time of enrollment, 4 had bone and 3 had brain metastases. During the nivolumab chemotherapy, 2 patients had pneumonia, 1 patient had cancer pain and 1 had stroke. Other 4 patients had no critical complication during the treatment. Our study results suggest that Korean EAP participants had safety profiles consistent with what was previously reported in Checkmate-017,057 and supports the use of nivolumab in Korean population
광·열복합경화조건에 따른 폴리우레탄 아크릴레이트계 수지를 이용한 TPEE Mono-filament의 경화성 및 물성 연구
최주환,김아롱 한국섬유공학회 2019 한국섬유공학회지 Vol.56 No.5
Flexibility and hardness are very important for expressing color in textile materials using UV curing technology. In the preceding study, the lack of hardness resulted in dye migration challenges. In this study, we investigated the effects of an oligomer, hardener content ratios, and curing time on the UV and thermal dual curable resin on thermoplastic copolyester (TPEE) mono-filament while maintaining flexibility. We observed that an O-3 oligomer with 13,000 mPa·s viscosity, 11.25:4.65 ratio of HDI/Photoinitiator, photocuring time of 40 s, and thermal curing time of 5 min, showed the best formula conditions. By dual curable resin treatment of the TPEE filament, the tensile strength increased under all UV and heat treatments, but the elongation increased after 10 min of heat treatment. We also observed the surface and cross-section of the dual curing TPEE mono-filament.
ATO 복합사를 이용한 열차단 직물의 태양방사투과율 변화 연구
최주환,김대근,김선남,최동혁,이승걸,Choi, Joo Hwan,Kim, Dae Geun,Kim, Sun Nam,Choi, Dong Hyuk,Lee, Seung Geol 한국섬유공학회 2016 한국섬유공학회지 Vol.53 No.6
In this study, we manufactured ATO (antimony tin oxide) combined fibers to improve solar energy transmittance of sunscreen fabrics. The results indicate that the solar energy transmittance is improved with increasing sheath ratios and ATO content. We observed that the MS2-7W sample with 50:50 sheath/core ratio and 3 wt% of ATO content show the best performance. We also manufactured the sunscreen fabrics using the developed ATO combined fibers to check the performance of the thermal barrier. The results of the solar energy transmittance analysis show that an approximate 58% improvement was achieved for the thermal barrier over the commercial sunscreen fabric without any ATO content.