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Docosahexaenoic acid의 모유두세포 증식 효능 및 기전
고지연,오일중,강정일,최윤경,윤훈석,유은숙,고창익,안용석,Ko, Jiyeon,Oh, Il-Joong,Kang, Jung-Il,Choi, Youn Kyung,Yoon, Hoon-Seok,Yoo, Eun-Sook,Ko, Chang-Ik,Ahn, Yong-Seok 제주대학교 의과학연구소 2019 The Journal of Medicine and Life Science Vol.16 No.3
Docosahexaenoic acid (DHA), a principal of mackerel-derived fermented fish oil, increases the proliferation of dermal papilla cells (DPCs) via the upregulation of cell cycle-associated proteins such as cyclin D1 and cdc2 p34, and might promote hair-growth. However, the intracellular mechanisms that underlie the action of DHA in the proliferation of DPCs have not been investigated fully. In this study, we addressed the action mechanisms of DHA to trigger the activation of anagen in DPCs. DHA activated β-catenin signaling by the increased phosphorylation at serine 552 and serine 675 as well as the translocation and accumulation of activated β-catenin into the nucleus. In the other hand, DHA inhibited canonical TGF-β/Smad signaling by the decreased phosphorylation of Smad2/3. Taken together, the results indicate that DHA might stimulate anagen signaling via the activation of Wnt/β-catenin pathway, while the inactivation of canonical TGF-β signaling pathway in DPCs.
최성권(Song Kwon Choi),박동춘(Dong Chun Park),최윤경(Yoon Kyung Choi),이지은(Ji Eun Lee),이수선(Soo Sun Lee),박윤희(Youn Hee Park),유영옥(Young Oak Lew),김대훈(Dae Hoon Kim),남궁성은(Sung Kwen Namkoong) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.12
N/A Acardia is a very rare congenital anomaly occurring in less than 1 in 35,000 deliveries. Acardiac parabiotic twin has been reported only in multiple, monochronic pregnancies. This anomalous fetus is sustained in utero by parasitic anastomoses to the circulation of its usually normal co-twin and is therefore not compatible with extrauterine survival. A case of an acardiac parabiotic twin is described, and the literature concerning the incidence, classification and etiology of acardiac is reviewed.