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바이오인포매틱스(Bioinformatics) 서비스의 적정가격 산정에 관한 연구
최원훈,강경식 대한안전경영과학회 2016 대한안전경영과학회지 Vol.18 No.1
Bioinformatics service is very new and emerging in market that provides information such as whether or not occurrence of a particular disease through the base of DNA(Deoxyribonucleic Acid) & RNA(Ribo Nucleic Acid) sequence analysis. Recently, interest growing rapidly in utilization of the industrial purpose, but provision of commercialization like pricing and service packaging is not enough to go to market. For go-to-market, firstly refine the services and perform cost calculation of services in cost-plus method then estimate consumer utility by conducting conjoint analysis. Collectively, with cost and consumer utility result, optimal service price can be calculated.
박광우,최원훈,박성호,최진화,박석원,박진호 한국물리학회 2015 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.67 No.1
We investigated the volume averaging effect for air-filled cylindrical ionization chambers to determine the correction factors in a small photon field for a given chamber. We measured output factors with several cylindrical ionization chambers, and by using a mathematical method similar to deconvolution, we modeled the non-constant and inhomogeneous exposure function in the cavity of the chamber. The parameters in the exposure function and the correction factors were determined by solving a system of equations that we had developed by using the measured data and the geometry of the given chamber. The correction factors (CFs) were very similar to those obtained from Monte Carlo (MC) simulations. For example, the CFs in this study were found to be 1.116 for PTW31010 and 1.0225 for PTW31016 while the CFs obtained from MC simulations were reported as being approximately between 1.17 and 1.20 for PTW31010 and between 1.02 and 1.06 for PTW31016 in a 6-MV photon beam of 1 × 1 cm2. Furthermore, the method of deconvolution combined with the MC result for the chamber’s response function showed a similar CF for PTW 30013, which was reported as 2.29 and 1.54 for a 1 × 1 cm2 and a 1.5 × 1.5 cm2 field size, respectively. The CFs from our method were similar, 2.42 and 1.54. In addition, we report CFs for PTW30013, PTW31010, PTW31016, IBA FC23-C, and IBA CC13. As a consequence, we suggest the use of our method to measure the correct output factor by using the fact that an inhomogeneous exposure causes a volume averaging effect in the cavity of air-filled cylindrical ionization chamber. The result obtained by using our method is very similar to that obtained from MC simulations. The method we developed can easily be applied in clinics.
근접치료용 방사성 동위원소의 선량분포 확인을 위한 디지털 반도체 센서의 제작 및 평가
박정은,김교태,최원훈,이호,조삼주,안소현,김진영,송용근,김금배,허현도,박성광,Park, Jeong-Eun,Kim, Kyo-Tae,Choi, Won-Hoon,Lee, Ho,Cho, Sam-Joo,Ahn, So-Hyun,Kim, Jin-Young,Song, Yong-Keun,Kim, Keum-bae,Huh, Hyun-Do,Park, Sung-Kwang 한국의학물리학회 2015 의학물리 Vol.26 No.4
방사선 치료분야 중 근접치료는 방사성 동위원소를 체내에 직접 삽입하여 병변 세포를 사멸시키는 치료법으로써, 주로 고선량률 치료가 시행되고 있다. 현재 치료계획과 실제 선량 방출범위의 일치성 여부는 Film/Screen 시스템을 통해 확인하고, 확인된 선량분포에 따라 방사선 치료를 시행하고 있다. 선량 분포 확인 시 F/S 시스템을 이용할 경우, Film 현상조건에 따른 신호 왜곡과 반음영에 의한 저분해능으로 인하여 치료계획과의 선량 분포 일치성을 정량적으로 파악하기 힘든 단점이 있다. 본 연구에서는 방사선 근접치료 시 치료계획과 동일한 선량 분포 여부를 확인하는 디지털 검출시스템의 기초 연구를 진행하고자, PIB법을 이용한 $HgI_2$ 반도체 검출센서를 제작하였다. 또한 이를 근접치료선원을 이용해 평가함으로써, QA 시스템으로 이용 가능성을 검증하고자 하였다. 근접치료 범위의 확인을 위하여 SDD의 변화에 대한 신호 수집량을 평가한 결과, 치료 범위 이상의 거리에서는 산란선으로 추정되는 낮은 신호만이 측정되었으므로 치료 계획시와 동일한 치료 범위를 정량적으로 확인할 수 있었다. 또한 동일한 ${\gamma}$-선 조사 조건에 대한 재현성 평가 결과, 변동계수 1.5% 이내인 것을 확인하였다. 이와 같은 결과를 바탕으로, 본 연구에서 제작한 센서는 방사선 근접치료 QA 시스템으로 적용 가능할 것이라 사료된다. In radiation therapy fields, a brachytherapy is a treatment that kills lesion of cells by inserting a radioisotope that keeps emitting radiation into the body. We currently verify the consistency of radiation treatment plan and dose distribution through film/screen system (F/S system), provide therapy after checking dose. When we check dose distribution, F/S systems have radiation signal distortion because there is low resolution by penumbra depending on the condition of film developed. In this study, We fabricated a $HgI_2$ Semiconductor radiation sensor for base study in order that we verify the real dose distribution weather it's same as plans or not in brachytherapy. Also, we attempt to evaluate the feasibility of QA system by utilizing and evaluating the sensor to brachytherapy source. As shown in the result of detected signal with various source-to-detector distance (SDD), we quantitatively verified the real range of treatment which is also equivalent to treatment plans because only the low signal estimated as scatters was measured beyond the range of treatment. And the result of experiment that we access reproducibility on the same condition of ${\gamma}$-ray, we have made sure that the CV (coefficient of variation) is within 1.5 percent so we consider that the $HgI_2$ sensor is available at QA of brachytherapy based on the result.