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HBsAg 양성인 환자에서 Pre - S ( 2 )Ag 의 임상적 의의
김동섭(Dong Sub Kim),김경희(Kyung Hee Kim),최우창(U Chang Choi),이관식(Kwan Sik Lee),문영명(Young Myoung Moon),최흥제(Heung Jai Choi) 대한내과학회 1989 대한내과학회지 Vol.36 No.5
N/A The Pre-S(2) gene in the HBV DNA genome encodes a peptide in the HBV envelope which is called Pre-S(2) Ag, and this antigenie determinant stimulates the formation of anti-Pre-S(2). It has been reported that Pre -S(2)Ag appears in the early phase of acute viral hepatitis with HBV DNA, HBeAg, and there is a correlation between the titer of HBV DNA and that of Pre-S(2)Ag. We collected a total of 73 cases with a diagnosis of acute viral hepatitis, chronic hepatitis, liver cirrhosis, or asymptomatic carrier from April to September 1988 in order to check Pre-S(2)Ag, anti-Pre-S(2), HBsAg, anti-HBs, HBeAg, and anti-HBe, HBV DNA. The following results were obtained: 1) Pre-S(2)Ag was seen in 60 cases(82.1%) of 73 HBsAg positive patients. 2) Anti-Pre-S(2)Ag was not detected in all cases. 3) Pre-S(2)Ag was seen in 92.3% of HBeAg patients patients and in 60% of anti-HBe positive patoents. There was a statistical significance between the two groups (p < 0.05). 4) The mean value of Pre-5(2)Ag was 1.047±1.007 O. D. in HBeAg(+) patients and 0.369+0.463O.D. in anti -HBe(+) patients. There is a statistical significance between the two groups(p<0.01). 5) Pre-S(2)Ag was seen in 92% of HBV DNA(+) patients and in 75% of HBV DNA(-) patients and this was a statistical significance (p<0.05). 6) There was no relationship between the titer of HBV DNA and Pre-S(2)Ag. 7) The mean value of Pre-S(2) Ag w as 1.201±0.93 O.D. in HBV DNA(+) patients and 0582±0.785O.D. in HBV DNA(-) patients. There was no statistical significance. In concluion, Pre-S(2)Ag seemed to reflect the replication of the virus but not the degree of replication. Pre-S(2)Ag was suggested to have no more significance than HBV DNA or DNA polymerase, Pre-S(2)Ag disappeared later than HBV DNA, but earlier than HBsAg. We need a long-term follow-up study to deter- mine prognostic value with anti-Pre-S(2).
김경희,정현주,문영명,이관식,최우창,이희대 대한소화기내시경학회 1989 Clinical Endoscopy Vol.9 No.1
Recently therapeutic efficacy of stomach cancer was greatly improved due to early diagnosis and irnproved diagnostic and therapeutic modalities. Especially in early gastric cancer, 5 year survival rate is near 100%. Recarrence of early gastric cancer after curative surgery is rarely reported. Recently authors experienced one case of recurrent stomach cancer arising from remmnant stomach 14 years after gastrectomy of EGC type I(m), so we reports it here with review of literatures.