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음파영동 경피약물수송에 의한 Piroxicam Gel의 경피투과
최석주,오명화,김태열,Choi Suk-Joo,Oh Myung-Hwa,Kim Tae-Youl 대한물리치료학회 2002 대한물리치료학회지 Vol.14 No.4
Transdermal permeation enhancer has been used to increased skin absorption. External control of drug release and skin absorption can also be achieved by iontophoresis or phonophoresis. However, because several problems with iontophoresis are that it has a risk to skin damage because of the change of pH and the increase of current density in applying it and that it can be applied only in the form of water solution, This study is to enhance drug permeation via skin following application of ultrasound. For this goal, in gel containing piroxicam, the degree of skin permeation in vitro and anti-inflammatory effect in in vivo were investigated. Permeation study using hairless mouse skin was performed at 37 $^{\circ}C$ using buffer saline as the receptor solution. The amount of piroxicam were quantified using a HPLC system consisting of solvent delivery system. Following adoption of ultrasound 1 MHZ, it showed relatively high permeation rate where it was compared with non treated by ultrasound. The influence of duty cycle having an effect on skin permeation rate was slight higher in the case of using pulsed mode. Skin permeation increase attended by intensity of ultrasound, the permeation of trice was accelerated at 2.0 W/$cm^{2}$ than 1.0 W/$cm^{2}$. The skin permeation of piroxicam was substantially influenced by ultrasound. Anti-inflammatory effects were determined using carrageenan-induced paw swelling method in SD rat. Paw swelling tests showed that pulsed phonophoresis group was more effective than control group and only gel application group. The conclusion of phonophoresis was found to improve significantly the skin permeation in vitro and the anti-inflammatory effect in vivo.
산전 부신피질 호르몬 다회 투여요법이 조산아의 예후에 미치는 영향에 대한 비교 연구
최석주 ( Suk Joo Choi ),양순하 ( Soon Ha Yang ),최성진 ( Seong Jin Choi ),서용수 ( Yong Soo Seo ),김영아 ( Young Ah Kim ),노정래 ( Cheong Rae Roh ),김종화 ( Jong Hwa Kim ) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.11
목적: 본 연구의 목적은 산전 부신피질 호르몬의 다회 투여가 1회 투여와 비교하여 조산아의 호흡기계 합병증을 비롯한 조산아의 예후에 대한 영향을 분석하고자 하였다. 연구 대상 및 방법: 임신 24주에서 34주 사이에 조기 분만의 위험이 있는 282명의 산모들을 대상으로 후향적 고찰을 시행하였다. 연구 대상 산모는 부신피질 호르몬 투여 유무 및 횟수에 따라 (1) 부신피질 호르몬을 투여 받지 않은 군 (비사용군), (2) 부신피질 호르몬을 1회 투여 받은 Objective: The aims of this study are to determine the effects of multiple courses of antenatal corticosteroid therapy on the perinatal outcomes, especially the respiratory outcomes of the preterm neonates and to compare them with the single course of ant
최석주 ( Suk Joo Choi ) 대한산부인과학회 2010 Obstetrics & Gynecology Science Vol.53 No.1
태아 목덜미 투명대는 임신 제1삼분기 말 초음파에서 태아의 목 뒤 연조직의 경계와 표면을 덮는 피부조직 경계 사이에 체액이 차 있는 무에코성 피하 공간이다. 이 시기의 태아 목덜미 투명대 증가 (95 백분위수 이상)는 다운 증후군 등의 홀배수체 이상 및 다양한 태아의 구조적 기형과 깊은 관련이 있다. 태아 목덜미 투명대 증가는 임산부 혈청 PAPP-A 및 free β-hCG와 함께 복합선별검사를 하면 다운 증후군 진단의 정확도를 높일 수 있다. 특히 목덜미 투명대 증가를 포함한 복합선별검사는 임신 제2삼분기 선별검사에 비해 더 이른 임신 주수에 더 정확한 선별이 가능하다는 장점을 가지고 있다. 목덜미 투명대가 증가된 태아는 염색체 이상이 없더라도 유산, 사산, 선천성 심기형을 비롯한 주요 선천성 기형의 위험이 증가하며, 목덜미 투명대의 증가할수록 그 위험이 증가한다. 본 종설에서는 태아 목덜미 투명대 증가의 기전, 목덜미 투명대의 올바른 측정법 및 해석, 목덜미 투명대 증가의 처치 등에 관하여 정리해보고자 하였다. Fetal nuchal translucency (NT) is an echolucent space between the dorsal edge of soft tissue of the fetal neck and the linear echo of the skin observed in a midsagittal image measured at 11 to 13(+6) weeks of gestation. Increased NT (>95 percentile) is highly associated with fetal aneuploidy and congenital structural anomalies including congenital heart defects. In combination with maternal serum PAPP-A and free beta-hCG, increased NT has been demonstrated to provide efficient Down syndrome risk assessment, with a detection rate of 80-87% (5% false-positive rate), and it also allows earlier diagnosis of fetal aneuploidy. Even in the absence of aneuploidy, increased NT is still associated with an increase in adverse perinatal outcome including abortion, fetal death and a variety of fetal malformations. This paper will review the mechanism of increased NT, correct measurement of NT, and recent evidences for interpretation and management for the fetuses with increased NT.
어린선양 사르코이드증 ( Ichthyosiform sarcoidosis )
최석주(Suk Joo Choi),한을희(Eul Hee Han),권경술(Kyung Sool Kwon),정태안(Tae Ahn Chung) 대한피부과학회 1994 대한피부과학회지 Vol.32 No.1
Although acquired ichthyosis has been associated with a number of systemic illnesses, an association with sarcoidosis has rarely been reported. We report a patient with aquired ichthyosis of the lower and upper extrimities whose diagnosis of cutaneous sarcoidosis was confirmed by histologic examination. Systemic involvement in the patient revealed occular, pulmonary and nerve disease. A diagnosis of sarcoidosis must be considered when a patient presents with acquired ichthyosis. (Kor J Dermatol 1994; 32(1): 172-176)
첨규 콘딜롬에서 중합효소 연쇄반응을 이용한 Human Papillomavirus DNA 검색에 관한 연구
최석주(Suk Joo Choi),문두찬(Doo Chan Moon),권경술(Kyung Sool Kwon),정태안(Tae Ahn Chung) 대한피부과학회 1993 大韓皮膚科學會誌 Vol.31 No.4
Background : Condylomata acuminata is a sexually transmitted cisease which is caused by the human papillomavirus(HPV). The types of HPV causing condylomata acuminata are HPV 6,11,16,18. HPV 16 and 18 are related to anogenital carcinoma. Objective : The goals of this study were to determine the types cif HPV in condylomata acuminata, and to investigate the relationship between condylomata acuminata and anogenital carcinoma. Methods : Polymerase chain reaction and restriction fragment le igth polymorphisms were performed in the paraffin-embedded tissues of 17 cases of condylomata acciminata. Results : HPV DNA was detected in all of 17 cases of condylomata accuminata tested. HPV 6 and 11 were found in 53% (9/17) and 41% (7/17) of the samples, respectiiely. HPV 16 and/or 18, which are related to anogenital carcinovia, were not detected, except in one case in which HPV 16 was found to be superimposed with HPV 6 and 11. Conclusion : These results suggest that most of condylomata acumirata are caused by HPV 16 and 11, and there is not so much risk of this disease transforming into the aiogenital carcinoma. (Kor J Dermatol 1993;31(4):507-516)
수중운동이 스테로이드를 투여한 흰쥐의 골격근 무게 및 단백질 함량에 미치는 효과
윤세원,김태열,최석주,Yoon Se-Won,Kim Tae-Youl,Choi Suk-Joo 대한물리치료학회 2003 대한물리치료학회지 Vol.15 No.3
The purpose of this study was to know the effect of aquatic-exercise on muscle atrophy which induced by steroid injection. The forty-eight Sparague-Dawley adult male rats were assigned to the 4 groups; Group I (distilled water injection), Group II (steroid injection), Group III (distilled water injection with aquatic exercise), Group IV (steroid injection with aquatic exercise). We observed their body weight, muscle relative weight, myofibrillar protein content. The results of this study were as follows; 1. Body weight was decreased rapidly on steroid injection groups in comparison with distilled water injection groups after 2 weeks (p<0.01), but that was almost recovered as before test on steroid injection group with aquatic exercise. 2. The relative weight of gastrocnemius muscles was decreased on steroid injection groups in comparison with distilled water injection groups. however, Decrease of it on steroid injection group with aquatic exercise for steroid injection group was fallen. There was very significant difference after 4 weeks (p<0.01). 3. Myofibrillar protein content of gastrocnemius muscles was decreased on steroid injection groups in comparison with distilled water injection groups. however, Decrease of it on steroid injection group with aquatic exercise for steroid injection group was fallen. There was significant difference after 4 weeks (p<0.05).