한국인의 G Protein $\beta$3 Subunit유전자의 다형성과 뇌혈관 질환과의 상관성에 대한 연구

최민희,이진우,이경진,이효정,노삼웅,최현,조기호,홍무창,신민규,김영석,배현수,Choi Min Hee,Lee Jin Woo,Lee Kyung Jin,Lee Hyo Jung,Rho Sam Woong,Choi Hyun,Cho Ki Ho,Hong Moo Chang,Shin Min Kyu,Kim Young Suk,Bae Hyun Su 대한동의생리학회 2003 동의생리병리학회지 Vol.17 No.3

Background and purpose: Hypertension and obesity has been implicated in the most important risk factors for stroke. The original finding that the G-protein beta3 subunit (GNB3) C825T allele associates with essential hypertension and obesity has been confirmed in several different populations. Hence, our objective was to determine whether the GNB3 C825T polymorphism predicts interindividual variation in stroke. Method: We recruited 361 stroke patients (cerebral infarction, n=278; intracerebral hemorrhage (ICH), n=83) and 199 healthy control subjects. Subjects were genotyped for GNB3 C825T mutation and findings were investigated for association with stroke. Result: The GNB3 T/T type was significantly associated with cerebral infarction prevalence (OR, 1.98; 95% Cl, 1.14-3.46; p=0.015). While, ICH was not found to be significantly associated with GNB3 T/T type (OR, 1.63; 95% ICH, 0.74-3.56; p=0.219). Similarly, no significant association was determined between GNB T/C type, and cerebral infarction (OR, 1.09; 95% Cl, 0.68-1.74; p=0.716), and ICH (OR, 1.14; 95% Cl, 0.59-2.21; p=0.697). Conclusion: In clinical characteristics, this study shows no differences among GNB3 genotypes, that are BMI, WH ratio. hypertension rate, and ischemic heart disease rate, total lipid level, triglycerides level, total cholesterol level, HDL cholesterol level, prothrombine time, with the exception of LDL cholesterol concentrations. However, our subjects showed an inverse relationship between LDL cholesterol level and the risk of cerebral infarction. We have shown that the GNB3 T/T genotype is strongly associated with cerebral infarction. (OR, 1.98; 95% Cl, 1.14-3.46; p=0.015).

지식 엔진 기반 당뇨 유헬스 서비스 개발 사례

최민희(Min-Hee Choi),김정아(Jeong-Ah Kim),한수나(Soo-Na Han),장학철(Hak-Chul Jang) 한국정보기술학회 2010 Proceedings of KIIT Conference Vol.2010 No.-

의료서비스의 전문화 및 다양화 그리고 디바이스의 발달은 대면 중심의 의료체계에서 예방 사후관리, 맞춤형 의료서비스 등 새로운 의료서비스의 형태로 진화하고 있다. 본 논문에서는 지식 엔진 기반 당뇨 유헬스 서비스에 대하여 사례를 통해 환자 데이터를 지능적으로 처리하고 판단한 개인 맞춤형 의료 서비스를 제공해주는 방법을 제공하고자 하였으며. 지식 엔진 기반 당뇨 유헬스 서비스 설계 및 개발 운영 과정에서 주요 이슈들을 도출하여 새로운 의료서비스에 더욱 효율적이고, 간편하게 수행하기 위한 방법을 제공하고자 한다. The specialization and diversity of medial service and the development of device have caused new types of medical services such as prevention, after-care service, and the medical service based on patients' needs. The study examined the examples of Glycosuria U-health service based on knowledge engine to provide the way of individual based medical services, which processes and infers patients' data intelligently. It also aims to provide more effective and convenient method of new medical services by identifying the problems which are caused in the process of Glycosuria U-health service based on knowledge engine.

연구논문 : "그린 하모니"-대학생의 전인건강을 위한 원예치료 프로그램

최민희 ( Min Hee Choi ),이인숙 ( In Sook Lee ),조태동 ( Tae Dong Cho ),서정근 ( Jeung Keun Suh ) 한국환경과학회 2010 한국환경과학회지 Vol.19 No.11

This research was to find out the effectiveness of the horticultural therapy program based on the therapeutic factors and the must meaningful experiences of the clients. For this purpose "Green harmony" program focused on harmony through horticulture was implemented. It is based on the preposition that holistic health is promoted with harmonious relationships with oneself, other people, community and nature. The program has three-fold structure: In innermost it deals with the task of the late adolescent. i.e., self identity, secondly the experience of communication and solidarity in the group, and finally extension of interest to the community. For the therapeutic intervention, questions using the metaphor of the activity were given to the clients for the establishment of self-identity, while group activity mid the donation of the works let the second and third purpose accomplished. Outdoor activity, `Tire garden project`, has provided the clients with chances of the contact with nature, cooperation with other group members, and a contest to provoke enthusiasm. Also recycling and greening of the community were possible by utilizing old tires for the containers and by donating the final works to the community. For the evaluation of the result, the effect of the program on the stress of the college students was tested, and the most meaningful experiences during the participation to the program were asked to identify the therapeutic factors acknowledged by clients. "Green harmony" program has brought positive effects on the stress of the clients in spite of relatively short period of five weeks. The clients has acknowledged plant/nature contact and interactions between group members for the most meaningful experiences. This research suggests "Green harmony" horticultural therapy program based on the therapeutic factors is highly applicable for the general populations.

전신경락마사지 전 대추 섭취가 마사지 후 중년여성의 산화스트레스와 피로에 미치는 영향

최민희(Min Hee Choi),강상모(Sang Mo Kang) 한국인체미용예술학회 2014 한국인체미용예술학회지 Vol.15 No.4

This study attempted to develop and suggest a plan to maximize the effects of meridian massage for middle-aged women (aged 30s-50s) living in Seoul and Gyeonggi-do. For this, the effects of meridian massage with jujube tea. In this study, following meridian massage, fatigue sufferers were divided into two groups. A total of 8 people from the control group drank 100ml of water prior to the relaxing therapeutic treatment while those from the experimental group drank 100ml of jujube-infused (25g) water. After a 2-hour meridian massage, fatigue severity was assessed and a blood analysis performed. After meridian massage, fatigue severity improved from 'more than average' to 'mild or below' in five respondents (62.5%) in the jujube tea experimental group. The blood analysis revealed that after the meridian massage, lactic acid decreased by 4.0% and 32.1% in the control group and experimental group, respectively. In terms of uric acid, a significant decline was observed in both the control group (3.3%) and experimental group (6.6%). In terms of hormone changes, cortisol decreased by 28.7% and 39.5% in the control group and experimental group, respectively. Regarding serotonin, no significant difference was found in either group. Regarding oxygen free radical-related changes, SOD increased by 55.7% and 10.6% in the control group and experimental group, respectively. In terms of BAP, an 0.8% increase was found in the control group while a 4.9% increase was observed in the experimental group. In terms of D-ROMs, in contrast, the control group declined by 2.9% while the experimental group increased by 5.2%. Therefore, it appears that lowered fatigue was found after meridian massage in the experimental group because of the low lactic acid and uric acid levels. In addition, a decrease in cortisol levels, a slight increase in SOD and a significant increase of BAP had an effect on lowering fatigue as well. As a result,

녹차 섭취 경락마사지가 중년여성의 산화스트레스와 피로에 미치는 영향

최민희(Min-Hee Choi). 강상모(Sang-Mo Kang) 한국인체미용예술학회 2014 한국인체미용예술학회지 Vol.15 No.2

In terms of lactic acid levels, a statistically significant decrease was observed in both the control group (3.5%) and experimental group (35.4%). In terms of uric acid levels, a statistically significant decrease by 3.0% and 5.4% was found in the control and experimental groups, respectively. In terms of hormone changes, cortisol levels declined by 28.6% in the control group and by 32.4% in the experimental group with statistical significance. In terms of serotonin levels, no statistically significant difference was detected in either group. In terms of oxygen free radical-related changes, SOD increased with statistical significance by 22.9% in the control and by 41.3% in the experimental group. In terms of BAP, a 0.8% increase was found in the control group while a statistically significant increase (2.6%) was observed in the experimental group. In terms of d-ROMs, a statistically significant decrease was detected in the control (2.7%) and experimental (4.3%) groups. The results above reveal that the experimental group is weaker than the control group in terms of post-massage fatigue severity because of low lactic acid and uric acid levels. In addition, it appears that low cortisol, high SOD, high BAP and low d-ROMs had an effect on the results.

부모의 우울여부에 따른 12~15개월 부모-영아 간 상호작용 특성 연구

최민희 ( Min-hee Choi ),이경숙 ( Kyung-sook Lee ) 한국영유아아동정신건강학회 2015 영유아아동정신건강연구 Vol.8 No.1

본 연구는 부모의 우울 여부에 따른 부모와 12~15개월 영아의 상호작용 특성 차이에 대해 알아보고자 하였다. 연구대상은 서울에 위치한 종합병원 4곳의 산부인과에서 발달평가를 진행한 후, 본 연구 검사에 참여한 부모 60명과 영아 30명을 대상자로 선정하였다. 우울 척도 결과에서 총점이 7점 이상인 경우 우울이 높은 것으로 구분하여, 연구 대상자를 부모 모두 우울한 10쌍(20명), 모 우울이나 부 비우울한 10쌍(20명), 부모 모두 비우울한 10쌍(20명)인 총 세 집단으로 분류하였다. 본 연구에서는 부모의 정신건강을 알아보기 위해 우울 척도(CESD-10), 영아의 정신건강을 알아보기 위해 부모 작성형 영유아 모니터링 체계(K-ASQ), 영아 기질 검사(IBQ-R-S), 영유아기 사회ㆍ정서 문제행동 측정도구(ITSEA)를 사용하였다. 또한 부모와 영아 간의 상호작용을 측정하기 위해 비디오 녹화를 통한 질적 접근으로 진행하였으며, 부모-아동 상호작용 놀이평가도구(P-CIPA)와 모-영아 놀이 상호작용 측정도구(MIPIS)를 수정한 척도와 부모의 비전형적 행동을 측정도구(AMBIANCE)를 사용하였다. 본 연구의 결과를 요약하면 다음과 같다. 첫째, 부모 우울여부에 따른 부모우울집단, 모우울/부비우울집단, 부모비우울집단 간, 집단 내 부-영아, 모-영아 상호작용 차이를 보였다. 둘째, 부모 우울여부에 따라 부모의 비전형적 행동 특성에 차이를 보였다. 셋째, 부모의 우울여부에 따른 부모와 영아 간 상호작용은 상호관련성이 있는 것으로 나타났다. 넷째, 부모의 우울여부에 따른 집단 간 영아 발달 차이는 사회ㆍ정서 행동문제 측정(ITSEA)한 결과 부모가 우울한 집단일수록 영아가 낯선부적응과 수면 문제행동을 보이는 것으로 나타났다. 그러나 발달 수준 측정과 기질 검사에서는 부모의 우울여부에 따른 집단 간 차이는 없었다. This study examined characteristics of parent-infant (aged 12 to 15 months) interactions depending on the level of depression of parents. Subjects included 30 infants and their 60 parents. They received developmental assessment in the obstetrics and gynecology departments of four general hospitals in Seoul. The parents were grouped depending on the findings of the 10-item Center for Epidemiological Studies Depression Scale (CESD-10). Scores of seven or above were classified as higher depression and the parents were divided into three groups of ten pairs each: Group 1 - both parents are depressed; Group 2 -mother is depressed and father is not; and Group 3 - both parents are not depressed. Mental state (depression) of the parents was measured by CESD-10. For infants, Ages & Stages Questionnaires (ASQ), the infant monitoring system completed by the parents, Infant Behavior Questionnaire-Revised (IBQ-R-S), the assessment of infant temperament, and Infant Toddler Social Emotional Assessment (ITSEA) were administered. Parent-infant interactions were measured by Parent-Child Interaction Play Assessment (P-CIPA), a modified scale of Mother-Infant Play Interaction Scale (MIPIS), and Atypical Maternal Behavior Instrument for Assessment and Classification (AMBIANCE). The findings are as follows. First, there was a difference among the three groups in terms of father-infant and mother-infant interactions depending on depression of parents. Second, there was a difference in characteristics of atypical behaviors of parentsdepending on depression of parents. Third, there were correlations between parent-infant interactions and depression of parents. Fourth, in terms of difference in the developmental level among infants between groups which was measured by ITSEA, infants inGroups 1 & 2 showed a higher level of difficulties in adapting to unfamiliar environments and sleep problems than infants in Group 3. However, no difference was found between groups in terms of depression of parents by the K-ASQ and the IBQ-R-S.

『儀鳳四年皆土』글씨기와를 통해 본 新羅의 統一意識과 統一紀年

崔珉熙(Choi Min-Hee) 경주사학회 2002 경주사학 Vol.21 No.-

식물 소재 첨가가 분쇄 돈육의 육색 및 지방 산화에 미치는 영향

최민희(Min-Hee Choi),정해정(Hai-Jung Chung) 동아시아식생활학회 2008 동아시아식생활학회지 Vol.18 No.6

자연재난에 의한 전력설비 피해 예측을 위한 인공신경망(ANN) 알고리즘 개발

최민희(Min-Hee Choi),정남준(Nam-Joon Jung),이규철(Kyu-Chul Lee),정재성(Jae-Sung Jeong),서인용(In-Young Seo) 대한전기학회 2019 전기학회논문지 Vol.68 No.9

Damage to the power system caused by natural disasters, including typhoons, is gradually increasing. The amount of the power outage caused by major typhoons shows 1.25 million households by “Rusa” in 2002, 1.44 million by “Maemi” in 2003, 1.68 million by “Kompasu” in 2010, 1.93 million by “Bolaven” in 2012 and 0.25 million by “Chaba” in 2016. Power companies are striving to establish an integrated system and simulators to predict power facility damage by natural disasters in advance and to establish a rapid response system in case of damage. In this paper, we developed the power facility damage prediction algorithm applied artificial neural network (ANN) for 6 kinds of natural disasters such as typhoon, strong wind, heavy rain, heavy snow, cold wave and heat wave. The algorithm consists of three phases: ① the establishment of big data by extracting meteorological data from the Automatic Weather System from 2007 to 2018, ② the analysis of the correlation between the power failures and the weather conditions(such as wind speed, rainfall, etc.) and ③ the evaluation of damage prediction algorithms using the ANN. In particular, comparisons and analyses with the Linear Regression(REG) algorithm were performed to assess the accuracy of the ANN algorithm. This algorithm was applied to Typhoon “Chaba” in 2016 to predict the failure of electric wires and Cut Out Switch (COS) in Seogwipo. The prediction error(MAE) of the ANN is 0.127, which is better than the performance of the REG.

케이슨 구조계의 설계 최적성 평가

최민희(Choi Min-Hee),류연선(Ryu Yeon-Sun),김정태(Kim Jeong-Tae),나원배(Na Won-Bae) 대한토목학회 2005 대한토목학회 학술대회 Vol.2005 No.10