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RISS 인기검색어
- 검색키워드
- 저자 : 진호준(Ho Joon Jin) (검색결과 4 건)
- 무료
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김근호(Gheun Ho Kim),진호준(Ho Joon Jin),정우경(Woo Kyung Chung),안규리(Cu Rie Ahn),김성권(Suhng Gwon Kim),이정상(Jung Sang Lee) 대한내과학회 1995 대한내과학회지 Vol.49 No.1
N/A Objectives: Past researches on the biochemical properties and pathogenicity of hantavirus have been mainly from rodent isolates, and we performed this study to obtain human isolates from patients with hemorrhagic fever with renal syndrome (HFRS) and to analyze the rate and source of viral isolation. Methods: Blood and urine specimens were collected from 48 patients with HFRS and inoculated onto subconfluent monolayers of Vero-E 6 cells, and human isolates of hantavirus were identified by direct and indirect immunofluorescent techniques, immunoblot analysis, and reverse transcriptase-directed polymerase chain reaction(RT-PCR). Results: Nineteen viral isolates(31 samples) were recovered from the blood and urine of 48 patients(90 samples) during days 3-11 following the onset of illness. Isolation rates of the virus from whole blood, serum, plasma, urine, and peripheral blood monuclear cells were 75%, 30%, 25%, 25%, and 18%, respectively. Viruses were more frequently isolated during days 3-9 of the illness(37%) than after day 9 (17%). Specific hantavirus antigens of isolates were identified by both indirect and direct immunofluorescent techniques and immunoblot analysis. The hantairus genomic sequences were detected in some of the isolates by RT-PCR. Conclusion: Nineteen hatavirus isolates were successfully recovered from 48 HFRS patients, mainly in the whole blood. Further investigations will be required to elucidate the differences in the pathogenicity of these human isolates using serologic and molecular biologic methods.
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김혜영,한진석,이정상,김현리,김진,이중건,이서진,김근호,진호준,전은실,주권욱,나기영,정우경,오지은,엄재호,궁성수 대한신장학회 2000 Kidney Research and Clinical Practice Vol.19 No.5
The purpose of this study was to elucidate whether the molecular defect of acid-base transporters in renal tubules is related to the functional defect of urinary acidification in distal renal tubular acidosis(RTA). We performed NH₄Cl, furosemide, or bicarbonate loading test to evaluate renal acidification function, and immunohistochemistry using antibodies to H^+ -ATPase, Cl^-/HCO₃^- exchanger(band-3 protein), and Na^+/K^+ -ATPase in kidney tissue in 6 patients with RTA and renal cell carcinoma patients as normal controls. Kidney tissue was obtained either by percutaneous needle biopsy(RTA) or nephrectomy(NC). The results were as follows; 1) In all six RTA patients, proton secretory defect of distal acidification was shown by a failure to lower the urine pH after NHC1 loading or furosemide test or abnormally low urine-blood pCO₂ difference during bicarbonate loading. In two patients with RTA, proximal acidification defect was combined, which was demonstrated by increased fractional excretion of bicarbonate. 2) In mal control, intense H^+ -ATPase and band-3 protein staining was observed in collecting ducts. 3) In distal RTA patients, H6+ -ATPase and band-3 protein staining was not demonstrable or markedly decreased in the intercalated cells of distal nephron. 4) In two patients who had both proximal and distal RTA, H^+ -ATPase staining was markedly decreased in the brush border of proximal tubules as well as the distal nephron. In conclusion, the defect of acid-base transporters in renal tubule was related with the functional defect of urinary acidification in distal RTA.
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낭창성 신염의 임상적 고찰 및 사망과 관련된 예후 인자에 대한 분석
김성권,진호준 대한신장학회 2000 Kidney Research and Clinical Practice Vol.19 No.6
Objectives: Of 339 patients with systemic lupus erythematosus(SLE) observed at Seoul National University Hospital in Seoul, 221 fulfilled criteria for lupus nephritis. We evaluated the clinicopathologic findings, outcomes and prognostic factors of patients' survival. Methods: We searched computer system of our center using disease code for SLE from January 1973 to January 1995 and found 339 SLE patients among whom there were 221 definite lupus neplritis patients. We retrospectively reviewed medical records and investigated the influence of multiple prognostic factors on patients' survival using Cox hazard function analysis. Results: Of 221 patients, 89.6% were female. The mean age of onset of SLE was 27.7±10.4 years and the mean follow-up duration was 42.5±40.2 months. The most frequent symptoms at diagnosis were skin manifestations. Hypertension was diagnosed in 21.7% of patients and 21.6% had serum creatinine greater than 1.4mg/dL. Overall, 37.7% were nephrotic. Renal biopsy performed on 159 patients show the following World Health Organization Class distribution: Class I 1.3%, class II 8.8%, class III 6.3%, class IV 65.4%, class V 13.2%, class IV+V 5.0%. Remission of nephritis was observed in 31.3% of patients. At the last follow-up period, there were 23 patients with deteriorated renal function among 168 patients and renal failure developed in 3.2%. Twenty eight patients died, primarily from infection, with 86.2% and 78.3% 5-year and 10-year survival rates, respectively. Initial presence of renal insufficiency(serum creatinine≥1.4mg/dL) and treatment with prednisolone only were most important in predicting patients' survival. Combination treatment of high dose prednisolone and cytotoxic drug(azathioprine, oral cyclophosphamide, or iv cyclophosphamide) appeared to be beneficial for nephritis. Treatment modality was only independent risk factor associated with lower survival probability. Conclusion: The characteristics of our patients were not so different from those of others. Treatment modality and renal fnction were important predictors of fatality. Treatment with high dose prednisolone and cytotoxic drug improved the clinical outcome of lupus nephritis, as compared with prednisolone alone.
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