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池昌準,鄭克守 慶北大學校 醫科大學 1974 慶北醫大誌 Vol.15 No.1
大腸 또는 下腹部症狀을 가진 患者中 直腸鏡檢査에 依해 直腸粘膜이 正常 또는 여러 程度의 炎症所見을 나타낸 140例(cholera 27例 包含)에 對해서 直腸生檢 및 replica cyeology를 施行한 結果 다음과 같은 成績을 얻었다. 1. 直腸鏡檢査上 炎症의 所見이 있을때 生檢에서 粘膜의 炎症細胞가 增加해 있는 수가 흔히 있고 이 境遇에 replica cytology所見에서도 炎症細胞가 多數 觀察되는 수가 흔히 있기는 하나 그 關聯性은 그렇게 密接하지는 않았다. 2. 直腸鏡檢査上 異常所見이 없고 生檢 結果 亦是 正常인 例의 約 15%에서 replica cytology上 炎症細胞가 多數 觀察되어 炎症의 存在를 疑心케 하였고 3.8%에서는 아주 多數의 多形核白血球가 集團的으로 觀察되므로서 뚜렷한 炎症의 存在를 시사하였다. 3. 直腸鏡檢査所見上 充血像을 본 境遇에는 生檢에 依해 40%에서 粘膜炎症細胞의 增加를 볼 수 있었고 replica cytology檢査上으로는 50%에서 炎症의 所見을 볼 수 있었으며 10%에서는 아주 多數의 多形核白血球가 觀察되므로서 뚜렷한 炎症이 있음을 시사하였다. 4. 潰瘍을 隨伴한 大腸炎의 境遇(全 10例中 8例가 ameba性 大腸炎으로 判讀되었음) 潰瘍이 없는 粘膜部位에서 生檢과 細胞診을 한 結果는 生檢所見에 正常이 40%, replica cytology上 正常이 20%이었다. 5. Cholera例(27)例의 直腸鏡檢査所見은 多少間의 炎症所見을 나타낸 것이 18.5%이었고 生檢上 直腸粘膜에 炎症細胞의 增加는 29.6%에서 觀察되었으며 replica cytology檢査上으로는 18.5%에서 炎症의 所見을 나타내었고 7.4%에서 아주 多數의 多形核白血球가 觀察되어 뚜렷한 炎症이 있음을 시사하였다. 直腸鏡檢査, 生檢 및 replica cytology檢査上 cholera에 特異하여 보이는 所見은 없었다. 6. Replica cytology檢査는 大腸炎症의 診斷에 있어서 直腸鏡檢査 및 直腸生檢과 더불어 臨床에 利用해서 많은 도움을 줄 수 있는 檢査라고 생각되었다. Sigmiodoscopy, biopsy and replica cytology of rectum were done on 140 cases with colonic symptoms or lower abdominal discomfort including 27 cases of cholera and the following results were obtained. 1. Inflammatory findings by biopsy and replica cytology correlated fairly well with sigmoidoscopic findings but no close relationships between these three methods were noted. 2. About 3.8% of those with negative sigmoidoscopy and rectal biopsy (93 cases, excluding cholera) showed definite evidence of inflammation. 3. About 40 and 50% of those with hyperemic mucosa by sigmoidoscopy (10 cases) showed increased inflammatory cells by biopsy and replica cytology respectively and 10% showed definite evidence of inflammation by replica cytology. 4. On cases of colitis with ulcerations by sigmoidoscopy (10 cases), biopsy and replica cytology were done on areas of intervening mucosa between ulcers or erosions and about 60 and 80% of cases showed inflammatory evidence by biopsy and replica cytology respectively. 5. Among 27 cases of cholera, about 18% showed pictures of colitis by sigmodioscopy. Rectal biopsy presented increased inflammatory cells in the mucosa in about 29.6% of cases while replica cytology showed increased inflammatory cells in 18.5% and definite evidence of inflammation in 7.4%. 6. Replica cytology appeared to be a valuable method for the detection of inflammation of the rectal mucosa.
鄭俊謨,池昌準,鄭克守 慶北大學校 醫科大學 1974 慶北醫大誌 Vol.15 No.1
Types and incidence of primary chronic gastritis in Korean were examined based on 1086 cases without focal lesions such as peptic ulcer, benign or malignant growth, bezoar etc., among a series of 2000 cases of gastrofiberscopy performed during the past 5 years and 5 months from Jan., 1968 to Jun., 1973, at the Endoscopy Room of Kyungpook University Hospital. The results obtained were as follows: 1. Frequency of primary chronic gastritis was 34.8% and it was about 2.5 times more prevalent in male than in femal. 2. The incidence of superficial, atrophic and hypertrophic gastritis were 20.9%, 12.3% and 1.6% respectively. 3. Superficial gastritis appeared more frequent in younger age group although it was not much impressive. Atrcphic gastritis, on the contrary, showed increased frequency with age increment from 9.9% in 3rd decade to 40.0% in 8th decade. 4. Classification of chronic superficial gastritis with erosions to several types was tentatively done by the authors and pattern of marked inflammatory changes with erosions was most prevalent (45.6%) among them. 5. Overall incidence of primary chronic gastritis in Korean is no more higher than those reported in other countries and atrophic gastritis appeared much less in its incidence in Korean than reported in Japan.
Experimental Phasing Using Zinc and Sulfur Anomalous Signals Measured at the Zinc Absorption Peak
이상민,김민규,지창준,이진원,차선신 한국미생물학회 2013 The journal of microbiology Vol.51 No.5
Iron is an essential transition metal required for bacterial growth and survival. Excess free iron can lead to the generation of reactive oxygen species that can cause severe damage to cellular functions. Cells have developed iron-sensing regulators to maintain iron homeostasis at the transcription level. The ferric uptake regulator (Fur) is an iron-responsive regulator that controls the expression of genes involved in iron homeostasis, bacterial virulence, stress resistance, and redox metabolism. Here, we report the expression, purification, crystallization,and phasing of the apo-form of Bacillus subtilis Fur (BsFur) in the absence of regulatory metal ions. Crystals were obtained by microbatch crystallization method at 295 K and diffraction data at a resolution of 2.6 Å was collected at the zinc peak wavelength (λ=1.2823 Å). Experimental phasing identified the positions of one zinc atom and four sulfur atoms of cysteine residues coordinating the zinc atom, indicating that the data contained a meaningful anomalous scattering originating from the ordered zinc-coordinating sulfur atoms, in spite of the small anomalous signals of sulfur atoms at the examined wavelength.