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인삼 사포닌의 생화학적 연구 ( Ⅶ ) 돼지의 염통 Isocitrate Dehydrogenase 에 미치는 영향
주중노,한정호 ( Chung No Joo,Jung Ho Han ) 생화학분자생물학회 1976 BMB Reports Vol.9 No.4
It was attempted in this study to observe the effect of ginseng saponin, one of the major components of Panax ginseng roots on pig cardiac NADP^+ specific isocitrate dehydrogenase [ICDH(NADP^+), EC 1.1.1.42] and NAD^+ psecific isocitrate dehydrogenase [ICDH(NAD^+), EC 1. 1. 1.41] in the absence and presence of adenine nucleotides such as AMP, ADP, ATP and NADPH in vitro and the following results were obtained. 1) It was observed that the Michaelis constants (Km) of ICDH(NADP^+) for isocitrate in the presence of Mg^(++) and Mn^(++) under the experimental conditions were 4.5 × 10^(-5)M and 3.3 × 10^(-5)M respectively. 2) In the presence of Mg^(++), ICDH(NADP^+)-catalyzed reaction rate lowered in the presence of the saponin when the concentration of isocitrate was high (over 3.3 × 10^(-5)M) compared with Km but when the isocitrate concentration was low (below 1.0 × 10^(-5)M), moderate amounts of the saponin (8.3 × 10^(-5)%-8.3 × 10^(-4)%) stimulated the reaction significantly. A similar effect of the saponin was also observed at the ICDH(NADP^+) catalyzed reaction in the presence of Mn^(++). 3) It was observed that ADP(8.3 × 10^(-5)M) inhibited the ICDH(NADP^+) activity but its inhibition effect was not significant when the isocitrate concentration in the reaction mixture was high (3.3 × 10^(-4)M). The saponin (8.3 × 10^(-5)%) was found to lower the ADP inhibition at the low isocitrate concentration. AMP, ATP and NADPH inhibition of the ICDH(NADP^+) was also observed but the saponin was found unable to recover their inhibition of the enzyme activity. 4) It was realized that ADP was one of the cofactors for ICDH(NAD^+) catalyzed reaction and ATP inhibited this reaction. It was found that the saponin was not able to recover the ATP inhibition but stimulated the ADP activation of this enzyme. 5) It has been suggested that the ginseng saponin would behave amphoterically and its action might be dependent not only upon its own concentration but also upon the nature and concentration of substrate and effectors.
Simulation Analysis of Flexible Track Drilling Machines Based on ADAMS
Zhong-gang Zhu(주중강),Qi Zhang(장기),Jian-Hua Lv(려건화),Zhen Qin(진진),Sung-Ki Lyu(류성기) 한국기계가공학회 2018 한국기계가공학회지 Vol.17 No.5
Flexible track drilling machines are credited with important applications in the area of aircraft manufacturing because of their portability, quick installation capabilities, and high efficiency. However, their structures are special and the constitution principles and motion characteristics are difficult to control, increasing the development costs and research cycle in the context of the technology blockade of foreign companies. The simulation analysis of flexible track drilling machines can be conducted by applying virtual prototypes, shortening the development cycle and reducing the cost. In this paper, a model of a machine is established by using the SolidWorks software and imported into ADAMS to conduct kinematic and dynamic simulation analysis. During the analysis, the feasibility of the configuration is checked, a reasonable driving motion is chosen, potential deficiencies are found, and improvement actions are raised.