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- 저자 : 주남영(Nam Young Joo) (검색결과 3 건)
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간조직내 HBV precore 변이를 동반한 HbeAg 양성 만성 B 형간염 환자에서의 인터페론 치료효과
이연재(Youn Jae Lee),옥승철(Sung Cheul Ok),이상혁(Sang Hyuk Lee),설상영(Sang Young Seol),정정명(Jung Myung Chung),박영홍(Yeong Hong Park),주남영(Nam Young Joo) 대한내과학회 1998 대한내과학회지 Vol.55 No.1
N/A type, Group 2: mixed) were received 3-6 MU INF three times a week for 4-6 months, We did follow-ups for at least six months(mean : Group 1-11.3, Group 2- 13.7 months). A complete responder was defined as persis- tent(>6 months) normalization of transaminase and loss of HBeAg and/or seroconversion. Results : The HBV precore mutants were found in 15 cases(31.2%) among 48 patients: 7 cases(21.2%) in 33 HBeAg-positive patients and 8 cases(53.396) in 15 HBeAg-negative patients. The HBV precore mutants were more frequently found in HBeAg-negative patients(p= 0.043). Differences in severity of hepatic pathology were not observed in the wild-type versus mutant-type chronic hepatitis B patients(p =1.00). Initial response rate was not significantly different between two Groups(p= 0.228), but complete response rate had a lower tendency in Group 2 (p=0.073). Conclusion : There is a tendency for HBV precore mutants to be less responsive to INF therapy than wild type. Therefore the patients with chronic hepatitis B should be treated as early as possible in natural history of their liver disease before the emergence of HBV precore mutants.
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주남영,도복태,임원준,석욱,오용창,김명준,우종길,정정명 인제대학교 1998 仁濟醫學 Vol.19 No.1
총수담관 막양구조는 1939년 Carter 등에 의해 처음 보고된 이래 세계적으로는 약40예, 국내는 아직 많이 보고되지 않은 드문 질환이다. 저자들은 열을 동반하지 않고 황달 및 심와부 동통을 주소로 내원한 56세 남자 환자에서 내시경적 역행술로 진단하고 수술로 치료한 총수담관 막양구조 1예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. Common bile duct(CBD) web is a very rare disease. Since its first description in 1939 by Carter, about 40 cases have been reported in the world. This was found in a 56-year-old man who had the epigastralgia and jaundice without fever. He was diagnosed as CBD web by endoscopic retrograde cholangio-pancreatography (ER-CP) and treated with operation. We report this rare case with the review of literature.
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상부위장관 용종성 병변 265예의 내시경 및 병리조직 소견에 대한 연구
설상영,장윤식,윤상조,주남영,김민기,이상욱 인제대학교 1998 仁濟醫學 Vol.19 No.2
저자는 1988년 7월부터 1997년 12월까지 부산백병원에서 내시경 검사를 통해 상부 위장관의 용종성 병변이 확인된 265명 환자의 274 용종성 병변에서 용종을 올가미법, 박리 생검술, "O" ring 결찰술을 이용하여 절제술을 시행하였으며, 이들을 대상으로 임상적 및 조직학적 소견을 분석하였다. The gastrointestinal polyp is a premalignant lesion in varying degree. Polyps in the gastrointestinal tract can be removed by surgical excision, electrosurgical method, cryotherapy, regional radiotherapy and laser therapy with some limitations. Advance in fibroptic endoscopy have improved diagnostic capabilities and management in patients with gastrointestinal polyps and endoscopic polypectomy is the most simple and safe method in removal of these polyps. We have underwent endoscopic snare polypectomy, strip biopsy and "O"ring ligation on upper gastrointestinal tract polyps in 274 lesions of 265 patients who visited in Pusan Paik hospital from July 1988 to December 1997, and the clinical characteristics including histopathology has been evaluated. The results obtained were as follows : 1) The age distribution of patients were from 28-year old to 78-year old. The ratio of male to female was 1:1.45. 2) The common clinical symptoms presented were epigastric discomfort (38.4%), epigastric pain (28.1%) and indigestion (19.6%). 3) The number of patient wish single gastric polyp was 225(85%), and that of multiple gastric polyps was 40(15%). 4) The most common location of gastric polyps was antrum(47.2%) and followed by body(37.5%) and fungus(9.1%). 5) The removed polyps were mostly 0.5∼1cm(44.8%) in size and in the gross findings by Yamada classifications type II(41.9%) was most common. 6) Histological examinations of gastric polypoid lesions revealed that 63.1% of removed polyps were hyperplastic polyps and 24% of 7hose were adenomatous polyps. 7) Almost all cases showed no significant complication, but there were postpolypectomy abdominal pain in 20 cases(7.5%) and minor bleeding in 8 cases(3.0%). Finally, we concluded that endoscopic polypectomy is a safe and relatively simple procedure and postpolypectomy complication can be considerably reduced by conservative antiulcer therapy, So. most of polypoid lesions of upper gastrointestinal tract should be removed and meticulous pathological review is mandatory.
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