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간세포암 환자의 혈청 Des -γ - Carboxy Prothrombin , Alpha - Fetoprotein 및 Anti - p53 항체검사의 유용성
황은주(Eun Joo Hwang),박태희(Tae Hee Park),조 몽(Mong Cho),문태용(Tae Yong Moon),이은엽(Eun Yup lee),김순호(Soon Ho Kim) 대한소화기학회 2001 대한소화기학회지 Vol.37 No.6
Background/Aims: Des-γ-carboxy prothrombin (DCP) and α-FP have been used for diagnosing hepatocellular carcinoma (HCC). Recently, anti-p53 antibodies have been detected in sera of the patients with cancer. The diagnostic significance of the combination assay of DCP, α-FP, and anti-p53 antibodies was evaluated in patients with HCC. Methods: For 78 cases of HCC, 17 cases of liver cirrhosis, 32 cases of chronic hepatitis, and 23 healthy controls, the serum levels of DCP, α-FP and anti-p53 antibodies were measured by enzyme immunoassay. Their sensitivity, specificity and accuracy were also assessed. Results: In patients with HCC, the sensitivity of DCP and α-FP was 52.9% and 66.7%, which were significantly higher than 7.7% of anti-p53 antibodies. In detecting HCC, the specificity of DCP, α-FP and anti-p53 antibodies was 91.8%, 89.8% and 98.0%, and their accuracy was 69.2%, 75.8% and 45.2%, respectively. No correlation was found among three tumor markers. The sensitivity and accuracy in the combination assay of DCP, α-FP and anti-p53, and in that of DCP and α-FP were higher than in assay of each tumor marker or other combination, especially in small sized HCC. Conclusions: A combination assay of DCP, α-FP, and anti-p53 antibodies and a combination assay of DCP and α-FP are useful for diagnosis or early detection of HCC, but the diagnostic usefulness of anti-p53 antibodies is still uncertain because of its low sensitivity. (Korean J Gastroenterol 2001;37:448-484)