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미세전류 자극이 얼굴 피부개선에 미치는 영향에 관한 임상시험 연구
조승관,김성국,김용민,박세근,이지환,김한성,Cho, Seungkwan,Kim, Seong Guk,Kim, Yong-Min,Park, Se-Keun,Lee, Chi Hwan,Kim, Hansung 대한의용생체공학회 2016 의공학회지 Vol.37 No.5
This study examined the effectiveness of micro-current stimulation (MCS) to improve the facial skin qualities by performing clinical test. The MCS is generally known that provide healing response in the damaged tissue and pain relief through activating the adenosine triphosphate (ATP) and protein synthesis. In here, we can hypothesize that the improvement of facial skin qualities may occur due to MCS, since the induction of micro-current from outside may enhance the cellular activity according to ATP activation. From the clinical test, our results showed that a variety of evaluating categories, which is able to assess the skin qualities, significantly enhanced due to stimulation of micro-current after 7 and 14 days. Therefore, we can estimate that MCS in human facial skin may be effective to improve the skin qualities.
Wnt/β-catenin 신호 활성화를 통한 미세전류 자극의 지방생성 억제 효과
황동현,이한아,이민주,조승관,김한성,Hwang, Donghyun,Lee, Hana,Lee, Minjoo,Cho, Seungkwan,Kim, Han Sung 대한의용생체공학회 2020 의공학회지 Vol.41 No.6
This study aimed to evaluate the inhibitory effect of micro-current stimulation(MCS) on adipogenesis regarding with Wnt/β-catenin pathway using the ob/ob mouse and 3T3-L1 cell line. 6-week old ob/ob male mice were equally assigned to four groups: obese group(ob), obese with MCS groups(50 μA, 200 μA, and 400 μA). 6-week old C57BL/6J male mice were assigned to the control group(CON). We analyzed abdominal adipose tissue volume by using in vivo micro-CT and measured the body weight, feed intake, liver weight and triglycerides in serum. All the MCS groups showed that significantly reduced body weight and triglycerides in serum. In the case of liver weight and abdominal adipose tissue volume, the inhibitory effect of adipogenesis was shown in the 200 μA and 400 μA groups. To elucidate the anti-obesity effect of MCS, β-catenin, C/EBPα and FAS protein expressions were analyzed by western blotting. β-catenin expression was upregulated, C/EBPα and FAS expression were down-regulated in the relatively high-intensity groups(200 μA and 400 μA). Thus, the 200 μA and 400 μA for the intensity of MCS were chosen for cell experiments. In the 3T3-L1 cell line, Wnt/β-catenin pathway including Wnt10b, Wnt3a, β-catenin and Cyclin D1 was activated in all MCS groups. Accordingly, the expression level of C/EBPα was decreased during the differentiation and lipid droplet was significantly reduced in Oil red O staining results. These results suggest that the Wnt/β-catenin signaling might be activated by MCS with current intensities between 200-400 μA and it may lead to anti-obesity effects.
고지방 식이 섭취 소동물 모델을 활용한 전신진동 자극의 복부 지방 감소 효능 평가
황동현,김서현,이한아,이상엽,서동현,조승관,천슬기,한태영,김한성,Hwang, Donghyun,Kim, Seohyun,Lee, Hana,lee, Sangyeob,Seo, Donghyun,Cho, Seungkwan,Chen, Seulgi,Han, Taeyoung,Kim, Han Sung 대한의용생체공학회 2017 의공학회지 Vol.38 No.1
The prevalence of obesity has noticeably increased worldwide over several decades with various complication. Even though anti-obesity drug treatments have been spotlighted by resulting in effective mean weight losses, its adverse effects cannot be overlooked. Thus, this study aimed to evaluate the effects of multi-frequency whole body vibration, one of the mechanical stimulus, as a countermeasure against obesity. Thirty-two-6-week-old C57BL/6J male mice were equally assigned to four groups: the Control group (CON, n = 8), the Sham group (Sham, n = 8), the sham with single frequency whole body vibration (S+V, n = 8), and the sham with multi frequency whole body vibration (S+MV, n = 8). After 4 weeks, morphologic changes in the adipose tissue were evaluated from three-dimensional images using in vivo micro-computed tomography. At 4 weeks, the volume of the abdominal adipose tissue, which had the highest value in Sham group, noticeably reduced in S+MV group compared to it in S+V group. These results implied that the accumulation of abdominal adipose tissue can be effectively reduced through applying multi-frequency whole body vibration.
손량희(Ryanghee Sohn),최희석(Heuseok Choi),조승관(Seungkwan Cho),김한성(Hansung Kim),김영호(Youngho Kim) 대한기계학회 2008 대한기계학회 춘추학술대회 Vol.2008 No.5
We were performed the three dimensional motion analysis for the 'Arthritis Knee Brace(AKB)' which has widening effects on the knee joint condylar separation. The knee joint condylar separations were measured at 1.807㎜(lateral), 0.474㎜(center) and 2. 172㎜(medial) by the fluoroscopy. Finite elememt method result in condylar stress decrease at 3.951㎫ in femur and 4.556㎫ in tibia. However, three dimensional gait analysis showed that all three lower joints(hip, knee ankle) were more flexed during AKB walking, and ground reaction force was larger in AKB walking just before the push-off. In the future, the joint moment and power as well as the electromyogram have to be analyzed to find the biomechanical disadvantage of AKB.