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염증성 장질환과 5-ASA 투여가 임신 및 태아에 미치는 영향울산대학교 의과대학 서울아산병원 내과학교실
최지훈 ( Ji Hun Choi ),유혜승 ( Hye Seung Yoo ),양석균 ( Suk Kyun Yang ),명승재 ( Seung Jae Myung ),조윤경 ( Yun Kyung Cho ),이윤정 ( Yun Jung Lee ),변정식 ( Jeong Sik Byeon ),이진혁 ( Gin Hyug Lee ),정훈용 ( Hwoon Yong Jung ) 대한장연구학회 2004 Intestinal Research Vol.2 No.1
Background/Aims: 5-Aminosalicylic acid (5-ASA) preparations are the first-line drugs in the treatment of inflammatory bowel disease (IBD). The aim of this study was to examine the influence of IBD and its treatment with 5-ASA on pregnancy and fetal outcome. Methods: A total of 56 patients (ulcerative colitis 41, Crohn``s disease 15) experienced 84 pregnancies among 634 female patients with IBD between June 1989 and August 2003. The outcomes of 42 pregnancies exposed to 5-ASA during pregnancy were compared with those of 42 non-exposed pregnancies. Results: Pregnancy outcomes were not different between the exposed and non-exposed pregnancies in terms of live birth (85.7% vs 80.9%), abortion (11.9% vs 19.0%), stillbirth (2.4% vs 0%), preterm delivery (11.1% vs 5.9%), low birth weight (11.1% vs 8.8%), congenital malformation (2.8% vs 2.9%), and aggravation of disease during pregnancy (21.4% vs 16.7%). These figures appear to be similar to those of general population. Conclusions: Neither ulcerative colitis nor Crohn``s disease has any significant impact on pregnancy outcome, and 5-ASA does not increase the risk of congenital malformation.
양동훈 ( Yang Dong Hun ),명승재 ( Myeong Seung Jae ),장혜숙 ( Jang Hye Sug ),송진우 ( Song Jin U ),양석균 ( Yang Seog Gyun ),이진혁 ( Lee Jin Hyeog ),정훈용 ( Jeong Hun Yong ),홍원선 ( Hong Won Seon ),김진호 ( Kim Jin Ho ),민영일 대한소화기학회 2003 대한소화기학회지 Vol.42 No.6
Enteropathy-associated T-cell lymphoma (EATL) is an unusual primary gastrointestinal lymphoma, particularly associated with celiac sprue. This tumor usually affects the jejunum and grossly presents as multiple circumferential ulcers without the formation of definite tumor masses. Moreover, mesenteric lymph nodes are commonly involved. The patients have typically suffered from abdominal pain, diarrhea, or weight loss whereas some patients may manifest with nonspecific symptoms for a period of years or an acute emergency of perforation, obstruction, or hemorrhage. The clinical course of EATL is very unfavorable and the prognosis is poor. Both celiac sprue and EATL are very rare diseases in Asia, except India and Middle East. We report a 60-year-old male diagnosed as having EATL after segmental small bowel resection, who presented with recurrent gastrointestinal bleeding. (Korean J Gastroenterol 2003;42:527-532)
저등급 위점막연관림프조직형 림프종의 조직학적 관해 후 단클론성의 지속여부가 재발에 미치는 영향
김규종 ( Kim Gyu Jong ),이진혁 ( Lee Jin Hyeog ),정훈용 ( Jeong Hun Yong ),홍원선 ( Hong Won Seon ),김진호 ( Kim Jin Ho ),민영일 ( Min Yeong Il ) 대한소화기학회 2003 대한소화기학회 추계학술대회 Vol.2003 No.-
<목적> 조직학적 관해를 획득한 위 MALT 림프종 환자의 약 50~70%에서 지속되는 B-세포 단클론성의 임상적인 의미에 대해서는 아직 밝혀져 있지않다. 또한, 조직학적 관해가 질병으로 부터의 완전한 치유를 대변해 줄 수 있을지도 명확하지 않다. 본 연구에서는 3제 요법으로 조직학적 관해를 획득한 H. pylori 양성인 저등급 위 MALT 림프종 환자들을 대상으로 중합효소연쇄반응 (polymerase chain reaction, PCR)을 이용한 B
홍성수 ( Hong Seong Su ),이진혁 ( Lee Jin Hyeog ),정훈용 ( Jeong Hun Yong ),홍원선 ( Hong Won Seon ),김진호 ( Kim Jin Ho ),민영일 ( Min Yeong Il ) 대한소화기학회 2003 대한소화기학회 추계학술대회 Vol.2003 No.-
<목적> 최근 우리나라에서 역류성 식도염의 빈도가 증가하는 추세이며, 대부분의 역류성 식도염은 경도의 역류성 식도염으로 알려져 있으나, 역류성 식도염의 자연경과에 대해서는 보고가 없다. 본 연구의 목적은 역류성 식도염의 자연경과와 중증 역류성 식도염으로 진행하는 데 관여하는 인자를 알아보는 것이다. <대상 및 방법> 1996년 1월 1일부터 2000년 12월 31일까지 서울 아산병원 건강증진센터를 방문하여 상부 소화관 내시경상 역류성 식도염으로 진단된
위암의 조기 진단을 위한 위세척액과 위조직에서 Telomerase 활성도 및 Telomerase Reverse Transcriptase 발현
이현주 ( Lee Hyeon Ju ),명승재 ( Myeong Seung Jae ),박영환 ( Park Yeong Hwan ),조윤경 ( Jo Yun Gyeong ),정훈용 ( Jeong Hun Yong ),이진혁 ( Lee Jin Hyeog ),홍원선 ( Hong Won Seon ),양석균 ( Yang Seog Gyun ),김진호 ( Kim Jin Ho ) 대한소화기학회 2003 대한소화기학회지 Vol.42 No.3
Background/Aims: Telomerase activity and telomerase reverse transcriptase (TERT) expression have been proposed as a marker for malignancy. However, little is known about those markers in intestinal metaplasia (IM). This study was performed to evaluate the usefulness of telomerase activity in gastric washing fluid and TERT expression in tissue as a marker for early diagnosis of stomach cancer. Methods: Gastric washing fluid and biopsies were taken endoscopically. We examined the telomerase activity by telomeric repeat amplification protocol (TRAP) and the TERT expression by semiquantitative reverse transcription-polymerase chain reaction in 26, 21 and 15 cases of cancer, IM, and normal mucosa respectively. Results: The telomerase activity was positive in 65% of cancer, 44% of incomplete IM, and 33% of complete IM. The TERT was expressed in 89% of cancer, 81% of IM, but not in normal mucosa. The TERT expression level was higher in cancer and incomplete IM than in complete IM and normal mucosa (p<0.05). Conclusions: Telomerase activity in gastric washing fluid and TERT expression in tissue may have limited usefulness as a marker for the early diagnosis of stomach cancer. However, the increased levels of TERT expression in IM and cancer suggest that TERT expression may be associated with carcinogenesis in stomach cancer. (Korean J Gastroenterol 2003;42:183-189)
박종범 ( Bak Jong Beom ),양석균 ( Yang Seog Gyun ),명승재 ( Myeong Seung Jae ),변정식 ( Byeon Jeong Sig ),이윤정 ( Lee Yun Jeong ),이진혁 ( Lee Jin Hyeog ),정훈용 ( Jeong Hun Yong ),홍원선 ( Hong Won Seon ),김진호 ( Kim Jin Ho 대한소화기학회 2004 대한소화기학회지 Vol.43 No.1
Background/Aims: The aim of this study was to evaluate the clinical characteristics and course of Korean patients with Crohn`s disease (CD). Methods: A total of 113 patients who were newly diagnosed as having CD at the Asan Medical Center between October 1989 and December 2001 were included. Results: The male to female ratio was 1.9:1 and the mean age at diagnosis was 24.2±7.8 years. The disease location was the small bowel in 19.5%, the large bowel in 11.5%, and the both small and large bowels in 69.0% of the patients. Empirical anti-tuberculous medications were administered to 53 cases (46.9%). Major complications of CD were intestinal obstruction (25.7%) and perianal fistula (42.5%). The cumulative remission rate was 75.7% at 1 year and 80.7% at 3 years from diagnosis. The cumulative relapse rate was 30.7% at 1 year and 53.0% at 3 years from remission. The cumulative operation rate was 11.5% at 1 year and 13.1% at 3 years from diagnosis. Conclusions: There are no differences in the remission and recurrence rates between Korean and Western patients with CD. Although the cumulative operation rate seems to be lower in Korea than in Western countries, the cause of the difference is uncertain. Further studies are needed to determine the characteristics of CD in Korea. (Korean J Gastroenterol 2004;43:8-17)