관절원판 절제술후 중간삽입물 고정에 피브린 접착제의 응용

정훈,김형근,김영수,유기준,안병근,Chung, Hoon,Kim, Hyeong-Keun,Kim, Young-Soo,Yu, Ki-Jun,Ahn, Byoung-Guen 대한악안면성형재건외과학회 1992 Maxillofacial Plastic Reconstructive Surgery Vol.14 No.3

Meniscectomy is indicated for the internal derangement of disk with perforation and gross morphological changes, nonreactive to conservative treatment procedures. After the meniscectomy, permanent disk replacement can be followed. Variable materials have been introduced for disk replacement. Of them, relatively harder replacing materials should have been fixed with surgical wire only. This poor fixation method provide inadequate retentive force and conclusively can be attributed to postoperative noise, poor prognosis. We tried to use biocompatible fibrin adhesive in order to obtain additional fixation force in the method above mentioned and treated two patients with the late stage of internal derangement of disk In both cases, satisfactory results were obtained.

밭작업용 복합작업기의 작업하중분석에 관한 연구

한정우(Jeong Woo Han),김응경(Eung Kyeong Kim),정훈형(Hoon Hyung Jung),박영준(Young Jun Park) 대한기계학회 2018 大韓機械學會論文集A Vol.42 No.4

복합작업기는 트랙터에 장착되어 경운과 배토작업을 동시에 수행하는 다목적 밭작업용 농기계이다. 작업시에는 불규칙한 변동하중과 고하중을 받게 되므로 구조강도와 내구성 측면에서 매우 취약하다고 할 수 있다. 본 논문은 스트레인게이지 계측과 하중재구성기법을 활용하여 복합작업기의 작업하중이력을 도출하는 방법에 관한 연구이다. 복합작업기 구성품인 디스크 해로우의 구조해석결과를 토대로 변형률응답특성이 최대가 되는 최적의 응답지점을 찾고, 변형률응답특성이 독립적 상관성이 보장되는 범위에서 스트레인게이지 수량을 결정하였다. 필드 테스트에서 얻어진 계측 데이터는 신호 필터링을 통해 트랙터속도가 14 ~ 16 km/h 구간의 변형률이력을 도출하고, 하중재구성기법을 적용하여 하중이력으로 재구성하였다. x, y, z 방향의 하중 벡터를 합성하여 피로손상이 가장 큰 피로하중의 주방향을 찾았으며, 모든 하중을 주방향 축으로 투영시켜 등가하중이력으로 변환하였다. A composite working implement is an agricultural machinery work tool that performs simultaneous cultivating and ridging. This may be critical in terms of structural strength and durability, because these implements are subjected to irregular, random, and high loads during work. In this research, a load reconstruction technique utilizing strain gage signals measured with field tests was used to derive load histories for a disk harrow mounted on the composite working implement. Additionally, the optimum points at which the strain response reaches maximum were found using the disk harrow finite-element analysis results. A method is proposed for reconstructing the load histories from measured strain data at a tractor velocity of 14~16 km/h, identifying the principal direction with the highest fatigue damage direction in the x-, y-, and z-axes, and projecting loads on the axis for conversion into an equivalent load.

트레드밀 운동이 알츠하이머 형질전환 생쥐 뇌의 인지기능과 미토콘드리아의 PGC-1α, cytochrome-c 발현에 미치는 영향

구정훈 ( Jung Hoon Koo ),조준용 ( Jun Yong Cho ) 한국체육대학교 체육과학연구소 2013 스포츠사이언스 Vol.30 No.2

알츠하이머질환은 초기 미토콘드리아 내 Aβ-42 단백질의 축적으로 산화적 스트레스의 증가와 함께 미토콘드리아 기능이상을 일으킨다. 따라서 본 연구의 목적은 지구성 운동을 통한 인지기능 개선과 세포사멸의 손상지표인 Cytosolic Cytochrome c수준을 확인하고 미토콘드리아 기능 및 생합성에 관련된 PGC-1α에 미치는 영향을 알아보는데 있다. NSE/PS2m 알츠하이머 형질전환 생쥐 Tg-CON (n=5), Tg-EXE (n=5) 집단과 비 형질전환 생쥐 Non-Tg-CON (n=5), Non-Tg-EXE (n=5) 집단으로 구분하고 12주간 점진적인 부하를 주어 최종 12m/min, 60min/day, 5days/weeks 강도로 트레드밀 운동을 실시하였다. 먼저지구성 운동을 통한 인지능력검사에서는 수영거리 및 시간이 Tg-CON 집단에서 유의하게 가장 높았으며 지구성 운동 후 통계적으로 유의하게 감소하여 결과적으로 알츠하이머 형질전환 생쥐의 인지력 및 행동적 능력을 향상시켰다. 세포사멸에 관련된 cyto-Cytochrome c 축적은 Tg-CON 집단에서 유의하게 가장 높았으며 Tg-EXE 집단에서는 cyto-Cytochrome c 축적이 유의하게 감소하였다. 미토콘드리아 생합성에 핵심적인 유전자인 PGC-1α는 세포질 및 미토콘드리아에서 Tg-CON 집단에서 유의한 감소 나타났으며 지구성운동 후 유의하게 증가하였다. 따라서 지구성 운동은 알츠하이머질환 초기 미토콘드리아의 기능이상을 일으키는 산화적 스트레스를 완화시키고 미토콘드리아의 생합성을 증가시켜 알츠하이머질환의 초기 예방 및 치료기전으로 효과적인 방법이라고 생각된다. Mitochondrial dysfunction and oxidative stress are early event in Alzheimer Disease``s by the accumulation of Aβ-42 in the brain mitochondria. The purpose of this study was to investgate the effects of treadmill exercise training on cognitive performance, Cytosolic Cytochorme c and mitochondria function and biogenesis factors such as PGC-1α. All mice were divided into 4 gourps (Non Tg-CON, Non Tg-exe, Tg-CON, Tg-EXE). The running speed and duration of the exercise were gradually increased and on the last week of the 12 weeks training protocol, ran 12m/min, 60m/day, 5days/week. First of all, treadmill exercise has been shown to improve cognitive and behavior function in Tg-EXE group compared with Tg-CON group. Levels of cyto-Cytochrome c in Tg-CON group were very significantly higher than all other groups, whereas treadmill exercise training decreased the expression of cyto-Cytochrome c in Tg-EXE group. In addition, level of mt-PGC-1α and cyto-PGC-1α in Tg-CON group were very significantly lower than all other groups, whereas treadmill exercise significantly enhanced the expression of mt-PGC-1α and cyto-PGC-1α in Tg-EXE group. Taken together, these finding suggest that treadmill exercise training in Tg mice alliviated the cognitive performance and up-regulation of mitochondria biogenesis in the AD brain is the main targets for prevention and treatment.

운동과 뇌기능: 알츠하이머 질환을 중심으로

구정훈 ( Jung Hoon Koo ),조인호 ( In Ho Cho ),조준용 ( Jun Yong Cho ) 한국체육대학교 체육과학연구소 2014 스포츠사이언스 Vol.31 No.2

알츠하이머질환은 대표적인 신경퇴행성 질환으로 노인 인구의 증가에 따라 질환자의 수가 급격하게 증가하고 있다· 현재까지 알츠하이머 질환에 나타나는 주요 특징으로는 Aβ 단백질 축적에 의한 노인성 반점과 tau 단백질의 과인산화에 의한 신경세포 내 신경섬유원 축적으로 인해 뇌신경세포 사멸과 인지기능의 저하가 나타난다· 또한 알츠하이머 질환은 인슐린 저항성과 미토콘드리아 기능이상으로 뇌의 에너지 대사의 불균형이 나타나기 때문에 결과적으로 세포내 축적되어 산화적 스트레스를 일으키는 Aβ 단백질과 과 인산화된 tau 단백질의 축적을 지연시키거나 제거하기 위한 다양한 연구들이 진행되고 있다· 최근 운동이 알츠하이머 질환을 대상으로 세포내 축적되는 독성물질을 감소시키고 뇌신경세포의 사멸 억제 및 뇌신경세포생성을 증가시켜 인지력의 개선되는 것으로 보고되었다· 뿐만 아니라 운동은 알츠하이머 질환의 뇌의 인슐린 신호전달을 증가시켜 인슐린 저항성을 개선시키고, 미토콘드리아 생합성과 관련된 단백질의 발현을 증가시켜 결과적으로 뇌의 에너지대사에 효과적인 방법으로 제시되어 운동이 뇌 신경발달에 긍정적인 영향을 미칠 것으로 보고되었다· 하지만 아직까지 알츠하이머 질환을 치료하는 기전은 대부분 약물에 의존하고 있는 실정이며 운동을 통한 알츠하이머 질환에 대한 연구가 매우 부족하기 때문에 알츠하이머 질환과 운동에 관련된 구체적인 연구가 필요하다고 생각된다· Alzheimer``s disease (AD) is a representative neurodegeneration disorder that is increasing rapidly with the prolonging life expectancy and increasing elderly population· The two major pathological hallmarks of AD are the β-amyloid (Aβ) protein and neurofibrillary tangles (NFTs) in the brain and leading to neuronal cell death and ultimately cognitive dysfunction· Also brain insulin resistance and mitochondria dysfunction may significantly contribute to the AD, indicating that inhibiting and reducing of Aβ protein and NFTs is the main targets for prevention and treatment of AD· Recently, exercise decrease the Aβ protein, NFT and neuronal cell death and increase the neurogenesis and ultimately enhancement of cognitive function in AD· Moreover, exercise increase the insulin signaling pathway- relatived protein and mitochondria biogenesis factor, indicating that exercise may be beneficial in prevention or treatment of AD· However, in AD, the most of therapies have depended primarily drugs until now and effects of exercise is very short research· Therefore, more research is necessary to prove effect of exercise on AD·

측두하악장애자의 측방운동 궤적에 관한 연구

정훈(Hoon Jung),이준규(Jun-Kyu Lee),강동완(Dong-Wan Kang) 대한턱관절교합학회 1997 구강회복응용과학지 Vol.13 No.2

신뢰도 벡터 기반의 다단계 음성인식

전형배,황규웅,정훈,김승희,박준,이윤근,Jeon, Hyung-Bae,Hwang, Kyu-Woong,Chung, Hoon,Kim, Seung-Hi,Park, Jun,Lee, Yun-Keun 대한음성학회 2007 말소리 Vol.63 No.-

In this paper, we propose a use of confidence vector as an intermediate input feature for multi-stage based speech recognition architecture to improve recognition accuracy. A multi-stage speech recognition structure is introduced as a method to reduce the computational complexity of the decoding procedure and then accomplish faster speech recognition. Conventional multi-stage speech recognition is usually composed of three stages, acoustic search, lexical search, and acoustic re-scoring. In this paper, we focus on improving the accuracy of the lexical decoding by introducing a confidence vector as an input feature instead of phoneme which was used typically. We take experimental results on 220K Korean Point-of-Interest (POI) domain and the experimental results show that the proposed method contributes on improving accuracy.

풍력터빈 성능 검증을 위한 출력측정 유효영역 선정

오기용(Oh, Ki-Yong),정훈(Jun, Hoon),이준신(Lee, Jun-Shin) 한국신재생에너지학회 2009 한국신재생에너지학회 학술대회논문집 Vol.2009 No.06

Power generation of wind turbine which is installed in wind farm should be measured to predict economic feasibility of wind farm. Also electric power company want to verify wind turbine performance which is stated by manufacturer. The International Electrotechnical Commission(IEC) published 61400-12-1 Power performance measurements of electricity producing wind turbines for test of wind turbine power performance. In this paper, measurable sector of wind speed is analysed based on IEC 61400-12-1 to verify power curve of wind turbine with various wind turbine in wind farm.

Chronic Actinomycosis of the Cervical Lymph Node Simulating a Thyroid Neoplasm

Young Jin Suh(서영진),Hun Jung(정훈),Hyung Min Chin(진형민),Hyeon Min Cho(조현민),Yong Sung Won(원용성),Jun-Gi Kim(김준기),Woo Bae Park(박우배),Chung Soo Chun(전정수) 대한외과학회 2002 Annals of Surgical Treatment and Research Vol.62 No.5

올리브유의 기능성과 활성성분

허완(Wan Heo),이소윤(So Yoon Lee),임수영(Su-Young Lim),판정훈(Jeong Hoon Pan),김형민(Hyung Min Kim),김영준(Young Jun Kim) 한국식품과학회 2012 한국식품과학회지 Vol.44 No.5

Olive oil is widely consumed in Korea, and is a representative fat source in the Mediterranean diet, known to be effective in the prevention of coronary artery disease. In addition, diverse functionalities have been reported, such as anti-cancer, anti-oxidation, and anti-inflammation effects. In this review, the status of production and variety were investigated with respect to the functionalities of olive oil. The main functional constituents of olive oil are oleic acid, known to improve blood cholesterol, and the minor constituents are polyphenol, tocopherol, squalene, and phospholipid, the concentrations of which can be used to distinguish pressed from refined olive oil. A number of studies of the functionality of olive oil have dealt with the minor constituents, and the beneficial functionalities, such as anti-oxidation, anti-inflammation, and improving blood circulation have been reported. This review intensively investigates the functionalities and the responsible components, and suggests that continual studies on olive oil are necessary for the prevention of various metabolic diseases.

보중익기탕(補中益氣湯) 복용 후 재발생한 미만성 간질성 폐렴

김승구 ( Seung Gu Kim ),강건희 ( Gun Hi Kang ),김준재 ( Jun Jae Kim ),박현 ( Hyun Park ),백나나 ( Na Na Baek ),이현경 ( Hyun Kyung Lee ),신은아 ( Eun Ah Shin ),이영민 ( Young Min Lee ),이혁표 ( Hyuk Pyo Lee ),정훈 ( Hoon Jeung ) 대한결핵 및 호흡기학회 2008 Tuberculosis and Respiratory Diseases Vol.65 No.5

Many classes of drug, such as antineoplastic drugs and antiarrhythmic drugs, have potential to induce interstitial lung disease. Herbal medicines are also believed to have the potential to induce pneumonitis. However, to our knowledge, there are no reports of pneumonitis caused by herbal medications in the Korean medical database. We report a case of recurrent pneumonitis caused by a self rechallenge of the Herbal medicine Bojungikgitang (Bu-Zhong-Yi-Qi-Tang : Hochu-ekki-to). (Tuberc Respir Dis 2008;65:416-420)