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NANB 간질환 환자에서 2세대 효소 면역 검사법과 중합효소 연쇄 반응법을 이용한 C형 간염바이러스 감염의 진단
이복근(Bock Gyeon Lee),권기호(Ki Ho Kwon),박양훈(Yang Hun Park),김한성(Han Sung Kim),정찬수(Chan Su Jeong),제영성(Young Sung Jae),이준상(Joon Sang Lee),유방현(Bang Hyun Liu),박영홍(Young Hong Park),이기영(Kee Young Lee) 대한소화기학회 1994 대한소화기학회지 Vol.26 No.5
N/A The first-generation enzyme linked imrnumosorbent assay(ELISA) method to detect hepati- tis C virus(HCV) has been used with relatively good sensitivity in the diagnosis of chronic non A non B hepatitis infecton, but its sensitivity in cases of acute hepatitis remains poor. The secondeneration ELISA which uses recombinant proteins and synthetic peptides from both structural and nonstructural regions increases the sensitivity in diagnosing HCV infection, and diminishes the number of false-positive reactions. The polymerase chain reaction(PCR) has been used to detect infectivity of anti HCV positive patients more accurately, to evaluate ver- tical transmission, and to monitor the response to antiviral ther~apy for chronic HCV infection. Serum samples from 35 patients with non A non B type liver disease were tested by the secondeneration ELISA and the PCR to evaluate the roles of hepatitis C viral infections in NANB patients. HCV RNA was detected by single polymerase c~t~ain reaction technique using primers deduced from the 5noncoding region of HCV genome. Among the 35 patients, 27 pa- tients were positive for anti HCV (Group A), while 8 were negative for anti HCV(Group B). Among anti HCV positive patients, 11% and 33% o~f patients were related to the transfu- sion and acupuncture, respectively. We could detect HCV RNA in the sera from 27 patients (100%) in the group A and 4 patients(50%) in the group B. We conclude that the combination methods of secondeneration ELISA plus PCR reduce the chance of false diagnosis of HCV infection compared to the first generation ELISA and the PCR can be used to diagnose HCV infection in anti HCV negative hepatitis patients.(Ko- rean J Gastroenterol 1994; 26; 825 832)
간장 ( 肝臟 ) 및 담도 ( 膽道 ) : 특발성 세균성 복막염 환자의 예후 결정 인자에 관한 연구
강종식(Jong Sik Kang),문중갑(Joong Kap Moon),이승주(Seung Ju Lee),이정웅(Jung Woong Lee),정찬수(Chan Su Jeong),이준상(Jun Sang Lee) 대한소화기학회 1991 대한소화기학회지 Vol.23 No.2
N/A We examined 34 cases of spontaneous bacterial peritonitis retrospectively to evaluate the factors influencing prognosis in spontaneous bacterial peritonitis. The obtained results were as follows. The groups with higher serum bilirubin, lower ascitic glucose concentration, more abnormal y-GTP, combined hepatic encephalopathy and positive ascitic culture showed poor prognosis significantly. Also, the groups with increased frequency of admission by spontaneous bacterial peritonitis and cultured enteric organism (esp.E.coli) in ascites tended to show poor prognosis. But, fever, serum creatinine level, PMN fraction in ascites or peripheral blood, and postitive blood culture were not related to prognosis statistically.
김한성,이준상,조강일,정찬수,한경근 대한소화기학회 1992 대한소화기학회지 Vol.24 No.2
Cystic masses of the spleen are rare and identification of their origin is critical to proper management. They are thought to originate from an abnormality in the development of the spleen. Presenting symptoms are freguently due to compressive effects of the mass or due to infection. Cystic splenic masses are most commonly secondary and have no internal cellular lining. And they are usually related to prior splenic injury. Primary splenic cysts are very rare and have an epidermal lining. Computed abdominal tomography outlines the anatomy and character of cystic masses of the spleen. Cysts localized to a single pole can be treated by partial splenectomy. Authors had experienced a case of huge splenic true cyst who was treated by splenectomy without any complications. So this case is presented with a brief review of the literature.
이승주,문중갑,강종식,이정웅,정찬수,임승균 대한내과학회 1991 대한내과학회지 Vol.40 No.6
Annular subvalvular left ventricular aneurysm is a rare cardiac malformation occurring predominantly in blacks, and the developmental aspects of this malformation are not known. In Korea there has been one case report accompanied with subacute bacterial endocarditis. We experienced a case of subannular aortic aneurysm with bicuspid aortic valve in a 21-year-old man who had been diagnosed as subacute bacterial endocarditis. To our knowledge, this is the fourth report in the world of subannular aortic aneurysm with congenital bicuspid aortic valve. We speculate about the cause of the malformation in our patient. The deformed bicuspid aortic valve may have caused high pressure in the left ventricle, and the associated congenital disorder of the connective tissue in the wall near the atrioventricular groove may have caused herniation of the endocardium and formation of a subannular aortic aneurysm under this high pressure.
Diphenylhydantoin에 의한 중증 재생불량성 빈혈 1예
김한성,한경근,김종현,김경환,조강일,정찬수,정철호,제영성,임창현 대한내과학회 1993 대한내과학회지 Vol.44 No.5
DPH는 경련치료제 및 예방요법제로 가장 널리 사용되어 왔으며, 이 약제에 의한 부작용은 아주 드물게 조혈장기에 손상을 줄 수 있다. 저자들은 항경련제로 DPH 사용 중 갑자기 발생한 중중 재생불량성 빈혈 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Since 1938, Diphenylhydantoin (DPH) has remained one of the most widely used anticonvulsants for treatment and prevention of seizures. DPH may induce serious damage to the hematopoietic system. Especially, DPH induced severe aplastic anemia is one of the most severe complication and its incidence is extremely rare. We recently expreienced one case of severe aplastic anemia in 52-year-old woman following administration of DPH. Litreature was reviewed briefly.