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황금(Scutellaria Radix)의 에타놀 추출물이 백서 치조골 형성에 미치는 영향
박준봉,허익,권영혁,배기환,정종평,Park, Joon-Bong,Herr, Yeek,Kwon, Young-Hyuk,Bae, Ki-Hwan,Chung, Chong-Pyung 대한치주과학회 1997 Journal of Periodontal & Implant Science Vol.27 No.3
The purpose of this study was to evaluate the effects of ethanolic extracts of Scutellaria Radix on the alveolar bone formation in the extract socket of rat. Thirty-six Sprague-dawley rats were used in this study. Mean body weight of rat was $130{\pm}5g$. Experimental animal were administered 0.4% ,${\beta}-aminopropionitril$(Sigma, USA) with the solid commercial food for 5 days. All the maxillary 1st molar of the rats were extracted by using of the tissue forcep under the general anesthesia with Pentobarbital sodium(Tokyo Chemical Co, Japan) injection into intraperitoneal space. All the extracted rats were divided into two group, experimental group which were feeded the solid food mixed ethanolic extracts of Scutellaria Radix, and control group which were feeded same food without reagent. At 1, 3, 5, 7, 9 and 14th days after tooth extraction, rats in both groups were serially sacrificed respectively. All the specimen were treated as usual method and prepared Hematoxylin-eosin stain for the light microscopic observation. The results were as follows : 1. Bone formation of extracted socket starts from the area on remained periodontal ligament than other area. 2. In the case of administration of the extracted Scutellaria Radix showed rapid healing process of connective tissue than non-administrated group. 3. In the case of administration of the extracted Scutellaria Radixshowed rapid osteogenesis than non-administrated With above results, it was concluded that ethanolic extracts of Scutellaria Radix may play a favorable role on the healing process of exatraction socket after extraction in rats. It was suggested that further study to evaluate the different concentration and administration method of ethanolic extracts of the Scutellaria Radix into same experimental model.
Poly(L-lactide)와 돼지골기질에서 추출 부분정제한 골형성단백을 이용한 조형가능성 골형성유도체의 개발
이종호(Jong Ho Lee),정종평(Chong Pyung Chung),이승진(Sung Jin Lee) 대한구강악안면외과학회 2000 대한구강악안면외과학회지 Vol.26 No.2
The purpose of this study was to develop an osteogenic, biodegradable material using polymer and BMP. It was designed to have structural function and be moldable, for the reconstruction of load bearing areas and deformities of various configurations. Bone apatite was added to Poly(L-lactide)(PLLA) and made porous for osteoconductability and ease of BMP loading. The materials, with or without BMP purified from porcine bone matrix, were evaluated in cranial bone defect models in rats for biocompatibility and bone regeneration capability. The following results were obtained: The PLLA-BMP material with BMP added to the polymer showed 30% healing of cranial bone defects in rats during the 2 weeks to 3 months period of observation. The moldable PLLA agent without BMP also showed 25% bone healing capacity. Although new bone formation was incomplete in the critical size defect of rat cranium, it can be concluded that the unique moldability of those agents makes them useful for the reconstruction of various bone defects and maxillofacial deformities.
권영혁,박준봉,허익,정종평,한수부,이승진,Kwon, Young-Hyuk,Park, Joon-Bong,Herr, Yeek,Chung, Chong-Pyung,Han, Soo-Bog,Lee, Seung-Jin The Korean Academy of Periodontoloy 1998 Journal of Periodontal & Implant Science Vol.28 No.3
4 beagle dogs aged over one and half years and weighed 15 to 16 Kg were utilized in this study. Experimental dehiscent defects were made in the mandibular edentulous area after removal of lower premolar. e-PTFE membrane resorbable membrane, and PDGF-BB-loaded resorbable membrane were covered at the dehiscent defects around the dental implants respectively. Animal was sacrificed at 1, 2, 3 months respectively. Non-decalicifed specimens were made and mutiple-stained for light microscopic study. The results were as follows: 1. Dehiscent defects around the implant installed in the beagle dog were an excellent defect model for studying guided bone regeneration. 2. Fibroblasts penetrated into expanded-PTFE membrane was observed and inflammatory cell infiltration was also observed around the membrane. 3. Resorbable membrane was degradaded and resorbed at 1 month after application to the dehiscent defect. Though multinucleated giant cells were observed adjacent to the membrane, that had no reverse effect on the boe regeneration. 4. PDGF-BB-Ioaded resorbable membrane was same capability as the resorbable membrane and e-PTFE membrane in the guided bone regeneration. 5. PDGF-BB-Ioaded resorbable membrane-applied site was better than resorbable membrane-applied site in the speed and maturity of bone formation. Within the above results, it was suggested that PDGF-BB-Ioaded resorbable membrane might have same bone regeneration capacity as nonresorbable membrane in the dehisced implant of the beagle dog and potentiality to use in human subjects.
치과용 골유착성 임플랜트 고정체 형상의 응력 분산에 관한 연구
한종현,전흥재,정신영,허성주,최용창,정종평,구영,류인철,김명호,Han, Chong-Hyun,Chun, Hung-Jae,Jung, Sin-Young,Heo, Seong-Joo,Choi, Yong-Chang,Chung, Chong-Pyung,Ku, Young,Ryu, In-Chul,Kim, Myung-Ho 대한치과보철학회 2000 대한치과보철학회지 Vol.38 No.4
Finite element analyses were performed to study effects on stress distribution generated in jaw bone for various shapes of dental implants: plateau type, plateau with small radius of curvature, triangular thread screw type in accordance with ISO regulations and square thread screw filleted with small radius partially. It was found that square thread screw filleted with small radius was more effective on stress distribution than other dental implants used in analyses. Additional analyses were performed on the implant with square thread screw filleted with small radius for very-ing design parameters, such as the width of thread end, the height of the thread of the implant and load direction, to determine the optimum dimensions of the implant. The highest stress concentration occurred at the region in jaw Pone adjacent to the first thread of the implant. The maximum effective stress induced by a 15 degree oblique load of 100 N was twice as high as the maximum effective stress caused by an equal amount of vertical load. Stress distribution was more effective in the case when the width of thread end and the height of thread were p/2 and 0.46p, respectively, where p is the pitch of thread. At last, using tensile force calculated from the possible insert torque without breading bone thread, finite element analysis was performed on the implant to calculate pre-stress when the primary fixation of the implant was operated in jaw bone. The maximum effective stress was 136.8 MPa which was proven to be safe.
Change of plaque removal ability by worn toothbrush
이학철,양병근,이철우,이용무,류인철,정종평,한수부,Lee, Hak-Churl,Yang, Byung-Kun,Lee, Chul-Woo,Lee, Yong-Moo,Rhyu, In-Chul,Chung, Chong-Pyung,Han, Soo-Boo The Korean Academy of Periodontoloy 2004 Journal of Periodontal & Implant Science Vol.34 No.1
연구 목적: 3개월 간의 잇솔질에 따른 칫솔의 마모의 정도와 양상을 관찰하고, 이를 이용한 잇솔질 시의 치태 제거능력의 변화를 평가하여 일반적으로 권장되고 있는 3개월 주기의 칫솔 교체 주기의 근거를 실제 임상적으로 확인해보고자 하였다. 연구방법: 치주적으로 건강한 치과 대학생 52명을 대상으로 설문지를 통해 잇솔질 습관을 조사하고, 치석제거술을 시행하고 실험기간 동안 동일한 칫솔과 치약을 사용하게 하였다. 1주일 후와 2달과 3달째에 구강 내를 erythrosine으로 염색한 후 6개의 Ramfjord 치아의 plaque score를 측정하고, 3달 동안 사용한 칫솔을 수거하여 brushing surface area의 면적으로 마모도를 평가하였다. 결과: 6명이 탈락하였고 전체 부위의 plaque score는 1주 때와 비교하여 2,3 개월의 값이 통계학적으로 유의한 차이가 없었으나, 치간 부위의 plaque score는 3개월의 plaque score와 상관관계는 약하였다. 교체 주기, 잇솔질 횟수, 시간 등의 잇솔질 습관과 마모도의 연관성도 없었지만, 잇솔질 시간과 3개월째의 plaque score의 상관관계는 유의성 있는 결과를 보였다. 결론: 3개월 동안 사용한 칫솔의 치간 부위 치태제거 능력은 감소하였으며, 이의 임상적 영향에 대한 장기간의 연구가 필요하겠다.
법랑기질유도체가 탈회 치근표면에서 치주인대섬유아세포의 생물학적 성상에 미치는 영향
이강운,김태일,설양조,이용무,구영,류인철,정종평,한수부,Lee, Kang-Woon,Kim, Tae-Il,Seol, Yang-Jo,Lee, Yong-Moo,Ku, Young,Rhyu, In-Chul,Chung, Chong-Pyung,Han, Soo-Boo 대한치주과학회 2008 Journal of Periodontal & Implant Science Vol.38 No.4
Purpose: The aim of this study was to investigate the effects of EMD on demineralized root surface using human periodontal ligament cells and compare the effects of root conditioning materials(tetracycline(TCN), EDTA). Material and Methods: Dentin slices were prepared from the extracted teeth and demineralized with TCN and EDTA. Demineralized dentin slices were incubated at culture plate with 25, 50 and $100{\mu}g/ml$ concentration of EMD. Cell attachment, alkaline phosphatase activity test, protein synthesis assay and scanning electronic microscopic examination were done. Results: Cells were attached significantly higher in EMD treated group at 7 and 14 days. Cell numbers were significantly higher in EMD treated group. Alkaline phosphatase activity was significantly higher in EMD treated group at 7 and 14 days. Protein synthesis was significantly higher in EMD treated group at 7 and 14 days. Conclusion: Enamel matrix derivatives enhance the biologic activities of human periodontal ligament cells on demineralized root surface and its effects are dependent on the concentration of EMD.
민감성 치아에 대한 수산화인회석 함유 치약의 임상적 효과
김수환,박준범,이철우,구기태,김태일,설양조,이용무,구영,정종평,류인철,Kim, Su-Hwan,Park, Jun-Beom,Lee, Chul-Woo,Koo, Ki-Tae,Kim, Tae-Il,Seol, Yang-Jo,Lee, Yong-Moo,Ku, Young,Chung, Chong-Pyung,Rhyu, In-Chul 대한치주과학회 2009 Journal of Periodontal & Implant Science Vol.39 No.1
Purpose: The aim of this study was to compare the effectiveness of hydroxyapatite containing toothpaste with positive control toothpastes in reducing dentine hypersensitivity. Materials and methods: This clinical trial was a double-blind, randomized, parallel group comparison of two, namely hydroxyapatite containing toothpaste and strontium chloride containing toothpaste. A total of 55 subjects were included in this study. The subjects were given randomly assigned one of the two toothpastes after received tooth brushing instruction at baseline. Some clinical indices(PI, GI, PD), verbal rating score(VRS) for sensitivity to stimulus, the effect in relieving sensitivity and visual analogue scale(VAS) for sensitivity at baseline, week 2, week 4 and week 8 were assessed. All data were evaluated by intention-to-treat analysis. Results: Overall, PI and GI scores were significantly reduced compare baseline in all groups(p<0.05). In addition, there was significant difference in PI at 4 weeks and in GI at 4, 8 weeks between groups. The proportions of subjects relieved sensitivity were 70.4% in experimental group and 57.1% in control group at 8 weeks respectively. The VRS for sensitivity to three kinds of stimuli and VAS for sensitivity decreased according to time, there was no overall difference between two groups(p>0.05). Conclusion: This study demonstrated that the new hydroxyapatite containing toothpaste was similarly effective in reducing dentine hypersensitivity with pre-existing benchmark toothpaste.