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정재화(Jae-Hwa Jung),윤필영(Pil-Young Yun),명훈(Hoon Myoung),신재일(Jae-Il Shin),이종호(Jong-Ho Lee),김명진(Myung-Jin Kim) 대한구강악안면외과학회 2003 대한구강악안면외과학회지 Vol.29 No.6
Tamoxifen is an selective estrogen receptor antagonist widely used in the management of patients with breast cancer for more than 30 years. It was thought to act primarily through occupying the estrogen receptor sites in ER positive breast cancer cells and directly on cancer cell proper. These inhibitory effects, which have been shown to be independent of the ER, highlight new mechanism of therapeutic action of tamoxifen. The purposes of this study were to identify ER in oral carcinoma cell lines and to evaluate ER independent cytotoxic effect of tamoxifen. KB(SCC), HSC-3(SCC) and A253(ACC) cell line were used and capacity of cell proliferation, apoptosis, in vitro invasion and gelatin zymography were tested. ER expression of each cell line were detected by RT-PCR and immunocytochemistry. Dose dependent inhibition of cell proliferation and inhibition of gelatinolytic activity were observed in all oral carcinoma cell lines and significant difference of apoptotic index were observed in A253 and KB. Tamoxifen inhibited in vitro invasion in all experimental groups. ER expression was detected in KB and A253. These data suggest that tamoxifen may play a role in management of oral carcinoma by independent cytotoxic effect and more advanced research must processed confirming ER-dependent cytotoxicity.
1980-2019년 기간 동안 소아청소년 알레르기질환에서 항원 감작의 변화
정재화 ( Jae Hwa Jung ),김가은 ( Ga Eun Kim ),박미르 ( Mireu Park ),김수연 ( Soo Yeon Kim ),김민정 ( Min Jung Kim ),이용주 ( Yong Ju Lee ),김윤희 ( Yoon Hee Kim ),김경원 ( Kyung Won Kim ),손명현 ( Myung Hyun Sohn ) 대한천식알레르기학회 2021 Allergy Asthma & Respiratory Disease Vol.9 No.4
Purpose: Allergen sensitization is constantly changing, and understanding these changes can help manage and prevent allergic diseases. This research analyzed and compared the changes in allergen sensitization in children diagnosed with allergic diseases us-ing the skin test and the multiple allergen simultaneous test. Methods: We retrospectively analyzed the data on children who were diagnosed with allergic diseases and received immunother-apy at Yonsei Medical Center from 1980 to 1998 and they were screened for allergen sensitization at Severance Hospital from 2005 to 2019. Results: Between 1980 and 1998, and between 2005 and 2019, data on 3,205 (male, 70.3%; mean age, 7.2±2.9 years) and 15,318 children (male, 62.8%; mean age, 8.8±4.5 years) were analyzed. The sensitized allergens that appeared in the 1980-1998 included Dermatophagoides farinae (91.0%), Dermatophagoides pteronyssinus (76.3%), cockroach (13.5%), and Alternaria (11.5%), in order of frequency; further, the sensitized allergens that appeared in the 2005-2019 included D. farinae (45.0%), D. pteronyssinus (39.6%), cat dander (12.2%), and dog dander (9.1%), in order of frequency. D. farinae and D. pteronyssinus demonstrated the highest sensitization rates, although the rates decreased gradually. The sensitization to cat dander and dog dander showed a growing trend, and sensiti-zation to Humulus japonicus, Candida, and cockroach decreased after 2005. Conclusion: Over the past 40 years, the allergen sensitization in Korean children with allergic diseases has increased. These changes reflect lifestyle and environmental changes and influence allergic disease management approaches. Thus, changes in allergic sensi-tization should be monitored continuously. (Allergy Asthma Respir Dis 2021;9:208-215)
정재화 ( Jae Hwa Jung ),김건엽 ( Keon Yeop Kim ),정성화 ( Seong Hwa Jeong ),김기수 ( Ki Su Kim ),이유미 ( Yu Mi Lee ) 한국치위생학회(구 한국치위생교육학회) 2014 한국치위생학회지 Vol.14 No.2
Objectives : This study aims to improve health and the quality of life of teenagers by identifyingan association between the periodontal status and oral health behaviors of Korean teenagers using2010 Korean National Oral Health Survey data. Methods : Subjects were teenagers aged from 12 to 15 in Korean National Oral Health Survey(KNOHS). The questionnaire consisted of periodontal status, general characteristics, periodontalrelated factors, and oral health related behaviors. Results : Gingival bleeding was found in 56.9% of teenagers because unhealthy periodontalstatus and tartars were found. Those who were 15 years old had unhealthier periodontal statusthan those who aged 12 years old. Those who lived in rural areas tended to have worse periodontalstatus than those who lived in the big cities. Access to dental floss, mouth rinsing solutionand regular dental checkup tended to make the healthier periodontal status. Smokers had theworse periodontal status than the nonsmokers. Conclusions : The oral health care in the teenagers aged from 12 to 15 is very importantbecause the permanent dentition is completed in this stage. It is necessary to lay emphasis onthe oral health improvement and dental caries prevention program to the teenagers.
격자볼츠만 방법을 이용한 도심지역 오염물질 확산에 대한 수치적 연구
정재화(Jae-Hwa Jung),변성준(Sung-Jun Byun),신명섭(Myung-Seob Shin),윤준용(Joon-Yong Yoon) 한국유체기계학회 2007 유체기계 연구개발 발표회 논문집 Vol.- No.-
The pollutant dispersion in a street canyon has been described in this study by using an two-dimensional lattice Boltzmann method coupled to the Smagorinsky sub-grid scale model. The pollutant source is divided ground-level source(Gl.S) and elevated source (ES). The obstacles were made a flat plate. The height of obstacle and distance of them were divided flow patterns as a isolated roughness flow, wake interference flow, skimming flow. The influence of the ratio between the height of the upstream and downstream canyon obstacles, as well as the gap distance between them was analyzed considering the situation of 'open country' and 'urban roughness'. The code for this research used large eddy simulation(LES) model by using lattice Boltzmann method(LBM).
합병증을 동반한 기관지 땅콩 흡인에서 체외막산소화 장치를 통한 치료 1예
정재화 ( Jae Hwa Jung ),설인숙 ( In Suk Sol ),윤서희 ( Seo Hee Yoon ),김민정 ( Min Jung Kim ),김윤희 ( Yoon Hee Kim ),신홍주 ( Hong Ju Shin ),박한기 ( Han Ki Park ),김경원 ( Kyung Won Kim ),손명현 ( Myung Hyun Sohn ),김규언 ( Kyu 대한천식알레르기학회(구 대한알레르기학회) 2016 Allergy Asthma & Respiratory Disease Vol.4 No.2
Foreign body aspiration commonly occurs, especially among children younger than 3 years of age. Most endobronchial foreign bodies may be easily removed by bronchoscopy and have a good prognosis. Despite advances in bronchoscopic procedures, difficulties in management of and complications from foreign body aspiration are still noted. We present a foreign body aspiration case with acute respiratory distress syndrome caused aspiration pneumonia, which was successfully treated by bronchoscopy under extracorporeal membrane oxygenation (ECMO). ECMO can be an effective and potentially life-saving method in complicated foreign body aspiration with uncompensated respiratory failure. (Allergy Asthma Respir Dis 2016;4:140-144)
비공간 데이터 일치 조건을 포함한 최근접 객체 질의 처리
정재화(Jae-Hwa Chung),강상원(Sang-Won Kang),길준민(Joon-Min Gil),정순영(Soon-Young Jung) 한국정보기술학회 2009 Proceedings of KIIT Conference Vol.2009 No.-
위치기반 서비스 분야에서 대표적으로 사용되는 최근접 객체(NN) 질의가 거리조건 이외에 비공간 데이터 일치 조건을 부가적으로 포함하고 있는 경우 R-tree 색인을 기본으로 하는 NN 처리 알고리즘은 효율적으로 질의 결과를 생성할 수 없다. 본 논문은 이러한 비공간 데이터 일치 조건을 포함하는 최근접 객체(NN) 질의 처리 기법을 제안하였다. 각각 유일한 비공간 데이터에 개별키 역할의 ‘타입’을 할당하고 색인 탐색의 효율성을 높이기 위하여 타입를 고려한 거리인 STDIST와 이를 보조하는 변형된 색인 구조인 MTR-tree 색인을 제안하였다. 또한 정확한 성능 평가 결과 STDIST와 MTR-tree 사용한 NN 알고리즘이 보다 R-tree를 사용하는 INN기법보다 약 20%~25% 우수한 것을 입증하였다. In location-based service, if nearest neighbor query contains non-spatial predicates as well as spatial condition, then the conventional processing techniques may not produce results efficiently. This paper defines nearest neighbor query that contains non-spatial predicates. For the efficient query processing, this paper defines each unique non-spatial data value as unique key "type" and suggests a novel STDIST that elevates efficiency of index tree traversal. Also suggests variant of R-tree, MTR-tree that contains auxiliary data for STDIST. In performance evaluation, NSPNN algorithm which adopts STDIST and MTR-tree outperforms 20%~25% over INN algorithm with R-tree.
김태호,정재화,Kim, Tae-Ho,Jung, Jae-Hwa 한국통계학회 2012 응용통계연구 Vol.25 No.1
통계청의 고용통계는 고용환경의 변화와 관련된 정보는 제공하지 않으며, 실업이 경기변동에 따라 변화하지만 함께 발표되는 월간산업동향과 관련된 분석은 제대로 이루어지지 않고 있다. 본 연구는 고용환경의 급변시 우리 사회의 주요 관심사인 실업 및 실망실업의 성향을 국내외 가격변수와 연계해 경기동행과 경기후행의 관계 안에서 통계적으로 분석하였다. 실망실업률은 일반 실업률에 비해 단기적 불균형에서 장기균형으로의 회복 속도가 빠르며, 특히 대부분 변수들의 변화에 상대적으로 민감하게 반응하는 것으로 추정되어 현실을 대변하는 의미있는 통계지표임을 시사한다. Published employment statistics do not provide enough information about the relationship of unemployment and economic and business conditions. This study investigates long-run equilibrium relations and short-run adjustment process of unemployment and discouraged unemployment with major price variables in the business coincident and lagging framework. Speed of adjustment from short-run disequilibrium to long-run equilibrium is found to be relatively faster for discouraged unemployment that appears more responsive to changes in most of explanatory variables. Discouraged unemployment is found to reflect reality and suggested to be a more meaningful statistical index.
김태호,정재화,김진수,Kim, Tae-Ho,Jung, Jae-Hwa,Kim, Jin-Soo 한국데이터정보과학회 2012 한국데이터정보과학회지 Vol.23 No.1
그간 보험소비자의 욕구가 다양화, 세분화되어 소비자 특성과 성향에 따른 선호도 파악의 중요성이 증폭되어 왔다. 보험상품의 판매채널 및 마케팅 환경 변화는 고객이 무엇을 중요시하며 상품을 구입하는지에 대한 분석이 요구되지만 이러한 분야에 대한 구체적인 연구가 많이 이루어지지 않아 마케팅 전략 수립에 애로가 있다. 본 연구는 보험 소비자들의 기본성향과 보험가입 패턴에 대한 구체적 정보를 파악하기 위한 설문조사를 실시하였으며, 효율적 통계적 기법을 적용하여 신규 고객 확보를 위한 모형을 구축해 방카슈랑스의 성공적 정착과 활성화 방안을 강구해 보았다. As insurance consumers' needs have been diversified and subdivided, it is increasingly important to grasp their preferences by characteristics and properties. Even though changer in sales channels and marketing conditions of insurance require to analyze what consumers take serious views to purchase, it is difficult to devise marketing strategies since not many concrete studies have been done in this field. A questionnaire survey was carried out to learn detailed information about basic disposition and buying patterns of insurance consumers. Applying efficient statistical techniques and then utilizing a model for securing new customers, this study attempts to explore a plan for rapid growth and successive establishment of bancassurance.