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정인애,강종백,Chung, In-Ae,Gang, Jong-Back Korean Society of Life Science 2002 생명과학회지 Vol.12 No.2
온도 기울기 전기영동장치를 이용하여 d(CXG)와 d(GXC) 염기의 열 안정성을 결정하는데 사람의 $\varepsilon$-글로빈 DNA조각을 사용하였다. 염기 쌍의 안정성은 이웃하는 염기서열에 의한 수소결합과 base stocking 상호작용에 의존한다. 염기 쌍의 안정성은 d(CXG) d(CYG)의 경우에 T.A<A.T<C.G<G.C이고 또한 d(GXC).d(GYC)의 경우는 A.T<T.A<C.G<G.C 이다. 그리고 d(GXC).d(GYC)의 경우에 mismatch 염기 쌍의 안정성은 G.T=T.G>G.A = A.G>C.T>T.C>C.A>A.C이다. Human $\varepsilon$-globin DNA fragment was used to determine the thermal stabilities of base pairs at d(CXG) and d(GXC) by Temperature Gradient Gel Electrophoresis(TGGE). The base pair stability depends on the hydrogen bonding interaction and base stacking interaction of neighbor base sequence. The orders of base pair stabilities were T.A<A.T<C.G<G.C for d(CXG).d(CYG) and A.T<T.A<C.G<G.C for d(GXC).d(GYC). And also heteroduplex TGGE suggested that the mismatch bases stabilities were G.T = T.G>G.A = A.G>C.T>T.C>C.A>A.C for d(GXC).d(GYC).
정인애,김기훈,박병규,김동휘 대한근전도전기진단의학회 2015 대한근전도 전기진단의학회지 Vol.17 No.1
The dorsal ulnar cutaneous nerve (DUCN) injury during wrist surgery often results in neuralgia, sensory loss, and sometimes neuroma at the nerve endings. This case is a rare report in that cutaneous nerve neuroma was diagnosed through ultrasonography without any surgical procedure and reinforces the usefulness of ultrasonography as a noninvasive complement to electrodiagnosis. In patients with focal entrapment neuropathy or cutaneous nerve injury diagnosed by electrodiagnostic studies, ultrasonographic examination is necessary to assess structural abnormality of the peripheral nerve in order to detect the injuries and neuromas that need further management.
Leptin 유전자 결핍 동물모델에서 단호박분말 투여가 지방대사변화에 미치는 영향
정인애,손태상,전상명,정현정,김옥경 한국영양학회 2023 Journal of Nutrition and Health Vol.56 No.5
Purpose: Obesity has emerged as a critical global public health concern as it is associated with and increases susceptibility to various diseases. This condition is characterized by the excessive enlargement of adipose tissue, primarily stemming from an inequity between energy intake and expenditure. The purpose of this study was to investigate the potential of sweet pumpkin powder in mitigating obesity and metabolic disorders in leptin-deficient obese (ob/ob) mice and to compare the effects of raw sweet pumpkin powder (HNSP01) and heat-treated sweet pumpkin powder (HNSP02). Methods: Leptin-deficient obese mice were fed a diet containing 10% HNSP01 and another containing 10% HNSP02 for 6 weeks. Results: The supplementation of ob/ob mice with HNSP01 and HNSP02 resulted in decreased body weight gain, reduced adipose tissue weight, and a smaller size of lipid droplets in the adipose tissue and liver. Furthermore, the ob/ob-HNSP01 and ob/ob-HNSP02 supplemented groups exhibited lower levels of triglycerides, total cholesterol, low-density lipoprotein cholesterol, fasting blood glucose, and insulin, as well as a reduced atherogenic index in comparison with the control group. Molecular analysis also demonstrated that the intake of HNSP01 and HNSP02 resulted in a diminished activation of factors associated with fatty acid synthesis, including acetyl-CoA carboxylase and fatty acid synthase, while concurrently enhancing factors associated with lipolysis, including adipose triglyceride lipase and hormone-sensitive lipase, in the adipose tissue. Conclusion: Taken together, these findings collectively demonstrate the potential of sweet pumpkin powder as a functional food ingredient with therapeutic properties against obesity and its associated metabolic disorders, such as insulin resistance and dyslipidemia.
회복실 간호사의 각성 섬망에 대한 지식과 각성 섬망 관련 업무 스트레스에 관한 연구
정인애,정덕유 병원간호사회 2014 임상간호연구 Vol.20 No.2
Purpose: This study was done to identify the level of knowledge on and stress from delirium among recoveryroom nurses, and correlations between these factors. Methods: In this study, 125 nurses agreed to participatein the study were surveyed from October 8 to October 28, 2013. Data were analyzed using t-test, ANOVA,Scheffè test and Pearson correlation. Results: Average percentage of correct answers to questions aboutdelirium was 81.9% and the mean score was 26.22 (±5.01). The mean score for recovery room nurses' workstress from emergency delirium was 3.86 (±0.99). Extent of knowledge on delirium significantly differed byage (F=15.017, p .001), length of clinical experience (F=22.132, p .001), length of recovery roomexperience (F=10.538, p .001), education (F=3.312, p =.040), and marital status (t=4.107, p .001). Stress from ED was significantly related to age (F=9.185, p .001), clinical experience (F=7.077, p=.001), andmarital status (t=-2.027, p =.045). Knowledge on delirium had a negative relationship with stress fromdelirium (r=-.514, p .001). Conclusion: Results show that nurses gained knowledge of delirium from theirown clinical experience indicating a need to develop educational programs to improve knowledge on deliriumand plans to reduce stress from delirium for recovery room nurses.
지속가능한 개발 관점에서의 국민의 삶의 밀착된 행복향상을 위한 SAC 모델 제안
정인애 한밭대학교 적정기술연구소 2014 적정기술 Vol.6 No.2
‘국민의 삶의 행복을 추구’라는 보다 새롭고 보다 실제적인 국민의 삶의 질적 향상에 대한 관심이 높아지고 있고 이에 따른 정부의 정책적, 제도적 노력이 수반되고 있다. 그러나 정부는 오랫동안 관료체제하에 운영관점(Operations Perspective), 기술중심(Technology Centered), 표준화(Standardization) 효율성(Efficiency)이 최우선의 가치가 되는 경제성장 위주의 R&D를 추구해왔기 때문에 국민의 삶과 밀착된 철학적, 방법적, 운영적인 추구를 하기에는 많은 어려움을 겪고 있다. 본 논문에서는 보다 국민의 삶에 밀착한 행복을 추구할 수 있는 대안으로 서비스디자인, 적정기술, 커뮤니티 디자인이 결합된 SAC(Service Design, Appropriate Technology, Community Design) 플랫폼을 제시하고 있다.
조사료와 Flaxseed oil 급여가 Friesian-Holstein 육우의 증체량과 분변 내 미생물 특성에 미치는 영향
정인애,정운시,전정태 강원대학교 동물생명과학연구소(구 강원대학교 동물자원공동연구소) 2016 동물자원연구 Vol.27 No.1
This study was conducted to evaluate the effects of grass and flaxseed oil on weight gain, fecal pH, microflora and acid resistance of fecal E. coli. in Friesian-Holsteins. Fifteen Holsteins were fed either conventional diet (C, n=5), grass (40%) and concentrate supplemented with flaxseed oil (60%) (T1, n=5) or grass only (T2, n=5) for 141 days, and T1 and T2 groups were grazed on pasture except feeding time. Grabbing fecal samples and measuring body weight were carried out at test day 1, 60, 120, 141. To evaluate acid sensitivity of fecal E. coli, feces were incubated in pH 2.0 anaerobic solution during 1 h at room temperature and measured survival rate. In terms of diets, C group had the highest n-6:n-3 ratio with 21.93, followed by T1 group (0.92) and T2 group (0.51). C and T1 group had higher final weight, total gain weight and average daily gain than T2 animals (p<0.05). The fecal pH of C group was maintained much lower than T1 and T2 group since day 120 (p<0.05). Total anaerobe in feces of C group were higher than the other groups since day 120 (p<0.05), but coliform bacteria were not significantly different among groups. Yeast and mold in feces of C group were significantly higher than the other groups from day 60 to day 141 (p<0.05), which is considered to be relevant to yeast in the diets. After feces were incubated at strong acid, more fecal E. coli of C group (34.09%) survived than those of T1 group (3.79%) and T2 group (1.02%) (p<0.05). From those results, it was considered that feeding grass and flaxseed oil to Holsteins enables to change fecal microflora, increase acid sensitivity of fecal E. coli and contribute to stay healthy for animals. It would be necessary to develop various grass feed diets and their applications for producing healthy and high quality meat products.
정인애(In Ae Chung),신동식(Dong Sik Shin),정병수(Byoung Soo Chung),고익태(Ik Tae Koh) 대한피부과학회 1988 대한피부과학회지 Vol.26 No.5
We report a case of cerebriform intradermal nevus. a cause of cutis verticis gyrata that clinically they resembled neurofibroma and revealed histopathologic finding consistent with intradermal nevus. The patient was a 6 year-old boy, who had a 17x18cm, soft, convoluted. pigmented mass over the parietal and occipital regions. The lesion had been present since birth and had been slowly increasing in size with convolution.