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신규 합성 KATP 통로 개방제인 SKP-450과 대사체 SKP-818의 흰쥐 적출 심장 및 대동맥에 대한 작용
정이숙(Yi Sook Jung),문창현(Chang Hyun Moon),유성은(Sung Eun Yoo),신화섭(Hwa Sup Shin) 대한약학회 1997 약학회지 Vol.41 No.2
The effect of potassium channel openers, SKP-450, SKP-818 and lemakalim have been compared in rat heart and aorta. In rat isolated heart, SKP-450 had a greater negative inotropic effect than lemakalim and KR-30818 against left ventricular developed pressure (LVDP) and double product of heart rate and LVDP (DP). In addition, SKP-450 had a greater effect than lemakalim and KR-30818 in increasing coronary flow, indicating a more potent vasodilating effect in coronary artery. Negative inotropic effect and coronary vasodilating effect of SKP-450 and SEP-818 were significantly reduced by 10 min-perfusion with 10-6M glyburide, a selective blocker of ATP-sensitive potassium channel. In rat aorta, SKP-30450 and SKP-30818 as well as lemakalim induced powerful concentration-dependent relaxations against norepinephrinc-induced tone (EC50, mcM : SKP-30450, 0.107 +/- 0.009; SKP-30818, 0.476 +/- 0.022; lemakalim, 0.565 +/- 0.039). These relaxant effects were significantly reduced by pretreatment with glyburide. In sununary, SKP-30450 and SKP-30818 showed greater negative inotropic and vasorelaxant effect than lemakalim in rat aorta with order of potency of SKP-30450 > SKP-30818 > lemakalim. These actions are suggested to be mediated at least in part by a mechanism which involves the opening of ATP-sensitive potassium channel.
정이숙(Yi Sook Jung),조태순(Tai Soon Cho),문창현(Chang Hyun Moon),신화섭(Hwa Sup Shin) 대한약학회 1997 약학회지 Vol.41 No.1
In the present study, capsaicin-induced desensitization of peripheral sensory nerves were investigated by using guinea pig bronchi, in which these nerves are stimulated with capsaicin to produce a contractile response via the release of sensory neuropeptides such as substance P and neurokinin A. The contractile response to capsaicin was inhibited by the combination of CP96345 and SR 48968 suggesting that the excitatory effect of capsaicin is mediated via both the tachykinin NK-1 and NK-2 receptor. Capsaicin produced in vitro-desensitization in dose-dependent manner, but after this in vitro-desensitization the response to NK-1 and NK-2 receptor agonist did not change. Systemic administration (s.c.) of capsaicin also desensitized significantly bronchial tissues but could not produce any change in the contractile response to the selective agonists of NK-1 and NK-2 receptor. Therefore, the present results suggest that functional desensitization to capsaicin-induced contractile response in guinea pig bronchi does not involve NK-1 and NK-2 receptor, while excitatory effect of capsaicin is mediated via both NK-1 and NK-2 receptor. In conclusion, it is suggested that capsaicin- induced excitation and desensitization involves somewhat different pathways.
당뇨병성 심혈관합병증에 대한 KST221085의 개선효과
정이숙(Yi Sook Jung),한호규(Hoh Gyu Hahn),이수환(Soo Hwan Lee),백은주(Eun Joo Baik),문창현(Chang Hyun Moon) 대한약학회 2001 약학회지 Vol.45 No.3
The present study was conducted to evaluate the effect of KST221085, a newly synthesized antidiabetic agent, on the hearts from streptozotocin (572)-induced diabetic rats. In isolated diabetic hearts, left ventricular developed pressure (LVDP), heart rate (HR) and coronary flow rate (CFR) were decreased compared to normal control, indicating cardiovascular dysfunction in diabetic heart. The treatment with 10mcM KST221085 remarkably improved the diabetes-induced contractile impairment, without any influence on HR. Reduced coronary flow in diabetic heart was also significantly increased by treatment with 10mcM KST221085, In isolated aorta·on diabetic rat, treatment with 10mcM KST22108S increased endothelium-dependent relaxation, suggesting that KST221085 can improve the impaired endothelial function in diabetic aorta. Our results suggest that KST221085 treatment can improve the cardiovascular dysfunction in STZ-induced diabetic rats.
횐쥐의 심혈관 기능에 대한 carbofuran의 독성작용
정이숙(Yi Sook Jung),이수환(Soo Hwan Lee),백은주(Eun Joo Baik),문창규(Chang Kiu Moon),문창현(Chang Hyun Moon) 대한약학회 2001 약학회지 Vol.45 No.6
Of all pesticides, carbamates are known to be most common, stance alternatives such as orcanophosphates have long lifetime and are extremely toxic to produce a delayed neurotoxic effect. Although a number of studies about toxicity of carbofuran, a most widely used carbamate, have been reported, its cardiovascular toxicity has not yet been studied. In the present study; we investigated its cardiovascular toxic effect in anesthetized rat in vivo and in isolated Langendorff rat heart. In anesthetized rat model, carbofuran (10 mg/tg) signiscantly reduced heart rate, and transiently increased blood pressure. In isolated rat heart, carbofuran (10mcM) caused a significant depression in the left ventricular developed pressure (LVDP), indicating contractile dysfunction by carbofuran. Carbofuran (10mcM) also decreased coronary flow rate (CFR) in isolated heart, indicating carbofuran-induced coronary dysfunction. These results suggest that carbofuran can cause cardiac dysfunction in rat in vivo and vitro.
정상 및 당뇨 흰쥐에서 주령과 절실에 의한 양파의 혈당조절작용 변화
문창현(Chang Hyun Moon),정이숙(Yi Sook Jung),김민화(Min Hwa Kim),이수환(Soo Hwan Lee),백은주(Eun Joo Baik),박세원(Se Won Park) 한국응용약물학회 1997 Biomolecules & Therapeutics(구 응용약물학회지) Vol.5 No.4
Onion (Allium cepa Linn) has been reported to have hypoglycemic activity in human and several animal models. In the present study, we performed intraperitoneal glucose tolerance test (IPGTT) in young (1.5 mo) and aged (5 mo) rats treated with onion in order to determine whether aging can influence on the anti-hyperglycemic effect of onion. In addition, we investigated the hypoglycemic effect of onion in streptozotocin-induced diabetic rats treated with aqueous extracts of onion (500 mg/kg, i.p., daily) for 4 weeks. Blood glucose level was determined in fasted and fed rats by using a glucometer (Johnson & Johnson). In glucose tolerance test, blood glucose level was maximally increased 15 min after glucose load (2 g/kg, i.p.), and recovered to the basal level 3 hr after glucose challenge in young and old rats. The maximum blood glucose levels of young and aged rat were 184 ± 7.49 and 225.2 ±12.55 mg/dl, respectively. A single i.p. injection of aqueous extract of onion (1 g/kg) 30 min before glucose challenge significantly decreased blood glucose levels at 15, 30, 60, 90 min after glucose load in aged rats, while the administration of onion did not show any significant effect in young rats. In onion-treated diabetic rats, significant hypoglycemic effect (p<0.05) was observed, and the effect was greater in fasted rats than in fed. In conclusion, these results suggest that anti-hyperglycemic effect of onion can be changed by age and fasting.
카드뮴이 뇌혈관 내피세포에서의 $PGE^2$ 및 COX-2 발현에 미치는 영향
박동현,김영채,문창규,정이숙,백은주,문창현,이수환,Park Dong-Hyun,Kim Young-Chae,Moon Chang-Kiu,Jung Yi-Sook,Baik Eun-Joo,Moon Chang-Hyun,Lee Soo-Hwan 환경독성보건학회 2006 환경독성보건학회지 Vol.21 No.3
In order to get insight into the mechanism of cadmium (Cd)-induced brain injury, we investigated the effects of Cd on the induction of COX-2 in bEnd.3 mouse brain endothelial cells. Cd induced COX-2 expression and $PGE_2$ release, which were attenuated by thiol-reducing antioxidant N-acetylcysteine (NAC) indicating oxidative components might contribute to these events. Indeed, Cd increased cellular reactive oxygen species (ROS) level and DNA binding activity of nuclear factor-kB (NF-kB), an oxidative stress sensitive transcription factor. Cd-induced $PGE_2$ production and COX-2 expression were significantly attenuated by Bay 11 7082, a specific inhibitor of NF-kB and by SB203580, a specific inhibitor of p38 mitogen activated protein kinase (MAPK). These data suggest that Cd induces COX-2 expression through activation of NF-kB and p38 MAPK, the oxidative stress-sensitive signaling molecules, in brain endothelial cells.
구속 스트레스 및 수면장애를 유도한 흰쥐에서 허브 복합추출물에 의한 개선 효과
정안나(An Na Jung),이보경(Bo Kyung Lee),이두이(Doo Yi Lee),이지인(Ji In Lee),정이숙(Yi-Sook Jung) 한국식품영양과학회 2016 한국식품영양과학회지 Vol.45 No.3
본 연구에서는 라벤더, 캐모마일, 레몬버베나, 타임, 바질의 복합 열수 추출물이 수면을 촉진하고 스트레스를 완화하는지 확인하기 위하여 농도에 따라 동물모델에 미치는 효과를 관찰하였다. 허브 복합추출물(HME)을 10, 30, 100 mg/kg의 농도로 3주간 구속 스트레스 모델과 수면장애 모델에 각각 경구투여 하였고, 실험 결과 구속 스트레스를 유도한 동물모델에서 HMEⅡ군(30 mg/kg)과 HMEⅢ군(100 mg/kg)은 혈장 내 코티졸과 IL-6 함량을 감소시켰으며, HMEⅢ군은 체중 대비 부신 무게도 유의적으로 회복시킨 것을 확인하였다. 수면장애 모델에서는 HMEⅢ군이 대조군에 비해 체중이 증가하였고, HME Ⅱ, Ⅲ군은 혈장 내 멜라토닌 수치를 높였으며 코티졸 수치를 감소시켰다. 이러한 결과를 통해 본 실험에서 사용한 허브 복합추출물이 농도에 따라 스트레스 완화와 수면장애 개선에 효과가 있음을 확인하였다. In the present study, we examined whether or not an herbal mixture extract (HME) has attenuation effects on immobilization stress and sleep disturbance in rats. Immobilization stress was induced by restricting movement using a constraint box for 2 h, and sleep disturbance was induced by exposure to 300 lx of constant light for 24 h and injection of caffeine (1 mg/kg, i.p.). Rats were orally treated with distilled water (vehicle) or HME for 3 weeks at different doses of 10, 30, and 100 mg/kg/d (HME Ⅰ, Ⅱ, and Ⅲ, respectively). In the immobilization model, HMEⅢ treatment significantly decreased adrenal gland weight, whereas HME Ⅱ and Ⅲ treatment reduced plasma levels of cortisol. HME Ⅱ and Ⅲ also reduced the level of IL-6. In the sleep disturbance model, HME Ⅱ and Ⅲ meaningfully reduced the plasma level of cortisol, and the increased plasma level of melatonin. HMEⅢ significantly increased body weight. HME reduced immobilization stress and ameliorated disturbance in rats. These findings suggest that HME may have beneficial potential for attenuation of sleep disturbance and stress.
이희주(Hee Joo Lee),문창현(Chang Hyun Moon),정이숙(Yi Sook Jung),김민화(Min Hwa Kim),이수환(Soo Hwan Lee),백은주(Eun Joo Baik),홍정(Jeong Hong),왕희정(Hee Jung Wang),김명욱(Myung Wook Kim) 한국응용약물학회 1998 Biomolecules & Therapeutics(구 응용약물학회지) Vol.6 No.4
Intravenous lipid emulsion is used extensively as a major component of parenteral nutrition for patients in the surgical intensive care unit. Abnormal cardiovascular function related to lipid infusion has been reported although conflicting results exist. In the present study, we investigated the effects of intravenous emulsions of long-chain triglyceride (LCT) and medium-chain triglyceride (MCT) on myocardial ischemia/ reperfusion injury and on platelet aggregation in rat. There was no difference between LCT and MCT considering the effects on left ventricular developed pressure (LVDP) and coronary flow rate (CFR) before and after ischemia/reperfusion in isolated rat heart. On the other hand, a difference was found between LCT and MCT with regard to their effects on heart rate (HR) and end diastolic pressure (EDP) after ischemia/ reperfusion. After ischemia/reperfusion, HR was significantly (P<0.05) reduced and EDP significantly (P<0.05) increased by LCT (18±2.0% and 42.8±8.9%, respectively), but not by MCT. Ex vivo platelet aggregation induced by collagen was reduced by LCT infusion, but not by MCT. These findings suggest that MCT may have slightly more favorable effect than LCT on the myocardial function after ischemia/reperfusion in rat.