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Flow Cytometer 를 이용한 , 결핵환자의 말초혈액 및 늑막저류액에서의 T - 임파구아형의 변화에 관한 연구
정은택(Eun Taik Jeong),정헌택(Hun Taeg Chung),박경옥(Kyung Ock Park) 대한내과학회 1989 대한내과학회지 Vol.37 No.1
N/A Recently, the development of monoclonal antibodies against human T lymphocytes subsets has allowed the classification of T cell subsets based on functional properties, namely helper/inducer and suppressor/ cytotoxic cells. The importance of a balance between helper and suppressor cells in maintaining immune homeostasis has recently been illustrated and abnormalities in these T cell subsets have been associated with tuberculous diseases. The flow cytometric study was performed to observe the change of the percentage of T-lymphocyte subsets in the peripheral blood of normal controls, pulmonary tuberculosis and tuberculous pleurisy patients, and in the pleural fluid of tuberculous pleurisy patients. The results obtained were as follows: 1) In normal controls, the percentage of T4+ and T8+ and T4+/T8+ ratio in peripheral blood were 43.66±7.91 %, 28.23±3.07% and 1.57±0.38, respectively. 2) In the peripheral blood of pulmonary tuberculosis and tuberculous pleurisy patients, the percentates of T4+ were 39.33±12.10 % and 40.24±8.01%, that of T8+ were 22.26±8.73% and 22.65±8.07% and the T4+/T8+ ratios were 2.06±0.55 and 2.06±0.99. T4 was decreased insignificantly. T8+ was decreased significantly and T4+/T8+ was increased insiginficantly in both groups compared with the normal controls. 3) The tuberculous pleurisy patients showed a significant increase in the percentage of T4+ cells (57.43±9.54 %) and in the T4+/T8+ ratio (3.07±1.27), but no change in the percentage of T8+ cells (20.73±6.00%) in the pleural fluid compared with peripheral blood.