연구논문 : In Silico QSAR를 이용한 식품유래 신경발달독성물질 검색 및 독성강도평가ㅂ

정연화 ( Yeon Hwa Jung ),김영원 ( Young Won Kim ),민정란 ( Jeong Ran Min ),정상희 ( Sang Hee Jeong ) 한국동물실험대체법학회 2011 동물실험대체법학회지 Vol.5 No.1

Developmental neurotoxicity (DNT) of chemicals is a serious threat to human health. Exposure to DNT during the perinatal period can result in behavioral abnormalities and cognitive deficits that appear later in life. The aims of this study were to predict human health impact of chemicals via food ingestion using chemical structure-based toxicity predicting program (In Silico QSAR). The determination factors that affect DNT risk potency were selected as developmental toxicity potential (DTP), blood-brain-barrier transfer, a predictor of logarithm of n-octanol/water partition coefficient (VLOGP),rat oral LD50, and rat chronic oral lowest-observed-adverse effect level (LOAEL). 39 kinds of chemicals were identified as high DNT potential chemicals. 2,3,7,8-Tetrachlorodibenzo-p-dioxin and hexachlorobenzene are classified as high DNT potential chemicals. Those chemicals need to be carefully treated as probable high potent DNTs and full scaled in vivo studies are required to characterize the risk of DNT.

백미 변온 저장중 과당의 변화

정연화(Yeon-Hwa Jung),강문선(Moon-Sun Kang),김무남(Mu-Nam Kim),전순실(Soon-Sil Chun) 한국식품영양과학회 1994 한국식품영양과학회지 Vol.22 No.6

변온 조건하에서 백미를 저장했을 때 수분활성에 따른 과당의 변화를 고찰한 결과를 요약하면 다음과 같다. 과당은 저장 초기에 0차반응으로 증가하다가 일정 시간 이후 1차반응으로 감소하였다. 반응속도는 수분활성과 저장온도가 높을수록 빨랐고, 각 수분활성에서의 활성화에너지는 과당 증가시 10.76~19.56, 감소시는 4.53~8.40㎉/mole이었다. 그리고 Q_(10)값은 증가시 1.74~2.74, 감소시는 1.26~1.54였다. Accelerated shelf-life test로 부터 구한 25℃에서의 shelf-life는 수분활성 (0.44, 0.52, 0.65, 0.75)에 따라 252, 212, 193, 162일의 범위였으며, 온도와 수분활성이 증가함에 따라 단축되었다. 변온조건에서의 실측치와 예측치를 비교한 결과 유효 온도차는 과당 증가시 0.49~2.52, 감소시는 1.03~2.02의 차이를 보였다. Kinetic studies were performed to investigate free-fructose content change in rice during storage. The rice was stored at various water activities (0.44, 0.52, 0.65 and 0.75) and at fluctuating temperature(30/50℃) over period of 22 weeks. At early stage of storage free-fructose content increased by zero-order reaction, whereas at later stage, it decreased by first-order reaction. The reaction rates were positively related to water activity and/or temperature during storage. Activation energies calculated at a range of aw 0.44~0.75 were found to be 10.76~19.56㎉/mole and 4.53~8.40㎉/mole, for the period of increase and decrease in the free-fructose contents, respectively. The shelf-life assessed at 25℃ was found to be 252(aw 0.44), 212 (aw 0.52), 193(aw 0.65) and 162(aw 0.75)days.

난용성 약물인 Ciprofloxacin 의 염 형성에 의한 용해도 개선에 관한 연구

정연화(Yeon Hwa Jung),손영택(Young Taek Sohn) 한국약제학회 1998 한국약제학회 총회 및 학술대회 요지집 Vol.- No.28

N/A N/A

In Silico QSAR를 이용한 식품유래 신경발달독성물질 검색 및 독성강도평가ㅂ

정연화 ( Yeon Hwa Jung ),김영원 ( Young Won Kim ),민정란 ( Jeong Ran Min ),정상희 ( Sang Hee Jeong ) 한국동물실험대체법학회 2011 동물실험대체법학회지 Vol.5 No.1

Developmental neurotoxicity (DNT) of chemicals is a serious threat to human health. Exposure to DNT during the perinatal period can result in behavioral abnormalities and cognitive deficits that appear later in life. The aims of this study were to predict human health impact of chemicals via food ingestion using chemical structure-based toxicity predicting program (In Silico QSAR). The determination factors that affect DNT risk potency were selected as developmental toxicity potential (DTP), blood-brain-barrier transfer, a predictor of logarithm of n-octanol/water partition coefficient (VLOGP),rat oral LD50, and rat chronic oral lowest-observed-adverse effect level (LOAEL). 39 kinds of chemicals were identified as high DNT potential chemicals. 2,3,7,8-Tetrachlorodibenzo-p-dioxin and hexachlorobenzene are classified as high DNT potential chemicals. Those chemicals need to be carefully treated as probable high potent DNTs and full scaled in vivo studies are required to characterize the risk of DNT.

주변성 거대세포 육아종의 증례보고

김성수,정연화,조봉혜,나경수,Kim Sung-Soo,Jung Yeon-Hwa,Cho Bong-Hae,Nah Kyung-Soo 대한영상치의학회 1997 Imaging Science in Dentistry Vol.27 No.2

The authors experienced one case of peripheral giant cell granuloma occurred at the gingiva of right maxillary molar in a 12-year-old male patient. The lesion showed amorphous calcification within soft tissue mass which made difficult to differentiate this lesion from peripheral ossifying fibroma and peripheral odontogenic fibroma clinically and radiographically. The final diagnosis was made histologically.

온도와 수분활성을 달리한 보리가루 저장시 유효 Lysine의 감소

송미영(Mee-Yeong Song),정연화(Yeon-Hwa Jung),전순실(Soon-Sil Chun),김무남(Mu-Nam Kim) 한국식품영양과학회 1988 한국식품영양과학회지 Vol.17 No.4

변온조건하에서 보리가루를 저장하였을 때 수분활성에 따른 available lysine의 손실을 반응속도론적으로 고찰한 결과 Avalilable lysine은 일차반응으로 감소하였으며 반응속도는 수분활성과 저장온도가 높을수록 빨랐고, 각 수분활성에서의 활성화 에너지는 6.02~10.32Kcal/mole, Q_(10)치는 1.34~1.65였다.<br/> Accelerated shelf~life test로부터 구한 25℃에서의 shelf-life는 60~216일의 범위였으며 온도와 수분활성이 증가함에 따라 단축되었다.<br/> 변온조건에서의 실측치와 예측치를 비교한 결과 유효온도차는 1.21~2.23℃였고 shelf-life는 실측치와 예측치가 약간 차이를 나타내었다. Lysine is known as a limiting amino acid in barley and easily inactivated by the browning reaction during processing or storage.<br/> The barley powders ground to 120 mesh in particle size were controlled at water activity of 0.44, 0.52, 0.65 and 0.75 by using saturated salt soultions and then stored at 35, 45 55℃. Another portion of the sample of which the water activities were controlled as same above was stored at 35℃ and 55℃ alternately with 7days interval.<br/> The reaction of available lysine loss in barley powders was found to be first order. The activation energies calculated from Arrhenius plot ranged 6.02~10.32Kcal/mole, and Q_(10) values were between 1.34 and 1.65.<br/> These kinetic parameters were used to predict the available lysine loss of barley powders under the fluctuatingtemperature storage.<br/> The predicted shelf-life at various water activities tested was a little higher than the actual values.

온도와 수분활성을 달리한 녹차 저장중의 비효소적 갈변

김영숙(Young-Suk Kim),정연화(Yeon-Hwa Jung),전순실(Soon-Sit Chun),김무남(Mu-Nam Kim) 한국식품영양과학회 1988 한국식품영양과학회지 Vol.17 No.3

변온조건하에서 녹차를 저장하였을 때 수분활성에 따른 browning development를 반응속도론적으로 고찰한 결과 brownung development는 영차반응으로 증가하였으며, 반응속도는 수분활성이 높을수록, 저장속도가 높을수록 빨랐고, 각 수분활성에서의 활성화 에너지는 1.5~2.4Kcal/mole, Q_(10)치는 1.07~1.12였다.<br/> Accelerated shelf-life test로부터 구한 25℃에서의 shelf-life는 57~113일의 범위였으며, 온도와 수분활설이 증가함에 따라 단축되었다. 변온조건에서의 실측치와 예측치를 비교한 결과 유효온도차는 2.66~5.64℃였고, shelf-life는 예측치가 높게 나타났으나 이 방면의 연구가 더욱 진행된다면 변온저장의 결과를 효율적으로 예측할 수 있을 것으로 예상된다. Non-enzymatic browning is a carbohydrate dehydration reaction, accelerated through the interaction of amino compounds. Reaction depends on several factors including temperature, reactant concentration, pH, water activity and specific ion concentrations, and results in progressive development of brown pigments in the affected food systems.<br/> The present study was designed to utilize a kinetic apporach to analyze the effect of temperature and water activity on the browning development in green tea. The green tea was controlled at aw of 0.33, 0.44, 0.52 and 0.65 using saturated salt solutions and then stored at 35, 45 and 55℃. Anthor portion of the sample of which the water activities were controlled in the same manner was stored at 35 and 55℃ alternately with 7 days interval. Simplified kinetic models were used to obtain the various kinetic parameters for browning development in green tea subjected to accelerated shelf-life tests(ASLT).<br/> The reaction of browning development was zero order. The activation energies calculated from Arrhenius plot ranged 1.5~2.4Kcal/mole and Q_(10) values were between 1.07 and 1.12. These kinetic parameters were then used to predict browning development under the nonsteady storage. Assessed from the parameters the shelf-lives at 25℃, the time to reach 1.02 O.D./ g solid at which severe brown color change could be detectable, ranged 57 to 113 days and showed decrease with increase in aw. The predicted shelf-lives at different water activities were a little higher than actual values.

시메티딘과 파모티딘의 다형에 대한 연구

정신희(Shin Hee Jung),임정아(Jung A Lim),전임작(Im Jak Jeon),정연화(Yeon Hwa Jung),이경이(Kyong Ee Lee),손영택(Young Taek Sohn) 한국약제학회 1998 한국약제학회 총회 및 학술대회 요지집 Vol.- No.28

N/A N/A

신체적 억제대 지침 개발 및 사용 효과

정윤중,김혜현,김은한,김지연,차세정,김유진,강정은,정연화,정영선,김영환,경규혁,홍석경,Jung, Yooun-Joong,Kim, Hea-Hyun,Kim, Eun-Han,Kim, Ji-Yeoun,Cha, Se-Jung,Kim, You-Jin,Kang, Jung-Eun,Chung, Yeon-Hwa,Jung, Young-Sun,Kim, Young-Hwan,Kyou 한국의료질향상학회 2014 한국의료질향상학회지 Vol.20 No.1

Objective: The objective of this research was to develop a guideline for more effective use of physical restraint on patients in the intensive care unit and training the nurses on it and applying it on clinical practice to assess its effectiveness. Method: This research analyzed the before and after effect of the development of a guideline for physical restraint by dividing the category into nurse and patient. In the case of nurse, a comparison of knowledge and nursing service regarding the use of physical restraint from before the training on physical restraint guideline(Jan. 2011) and after the training on physical restraint guideline(Dec. 2011) was made. In the case of patient, a comparison of physical restraint usage rate and average usage time, the number of unplanned extubation cases were compared from before the use of physical restraint (Jan.~Apr. 2011) and after the use of physical restraint (Sep.~Dec. 2011) were made. Result: After the training on the physical restraint guideline, the knowledge of the nurse and the nursing practice showed notable improvement by (p<0.000) and (p<0.048) respectively and in patient, physical restraint usage rate and average time of usage decreased by (p<0.001) and (p<0.001) respectively. And despite the decrease in the number of cases in which the physical restraint was used, the number of unplanned extubation cases remained the same. Conclusion: Physical restraint guideline training and guideline usage can be stated to have brought out positive effect in both the nurse and patient. In order to maintain such positive effects, continuous training is necessary and continuous revaluation is necessary, regarding knowledge and nursing practices.

상악 구치부 임플란트 치료를 위해 내원한 환자들에서 Cone-beam CT를 이용한 상악동의 평가

정창신(Chang-Shin Cheong),조봉혜(Bong-Hae Cho),황대석(Dae-Seok Hwang),정연화(Yeon-Hwa Jung),나경수(Kyeong-Soo Naa) 대한구강악안면외과학회 2009 대한구강악안면외과학회지 Vol.35 No.1

Objective: The purpose of this study is to determine the prevalence of sinus disease and abnormalities in patients scheduled for dental implant in maxillary posterior area using cone beam CT. Patients and Method: One hundred five maxillary sinuses in eighty-seven patients who underwent cone beam CT for dental implant in maxillary posterior area were included. Any patients who had previous history of sinus operations were not included. The sinus abnormalities were classified as follows ; normal (membrane thickness 〈2 mm), mucosal thickening (membrane thickness ≥ 2 mm and 〈6 mm), partial opacification (membrane thickness 〉6 mm but not full), full opacification and mucous retention cyst. The relationship between the remaining bone height, sinus symptoms and maxillary sinus abnormality was statistically surveyed. Results: Of 105 maxillary sinuses in 87 patients, 80 (76%) maxillary sinuses showed abnormalities ; 4 of 4 symptomatic patients and 76 of 101 asymptomatic patients. Mucosal thickening was the most common sinus abnormality. Only 3 (4%) of 80 maxillary sinus abnormalities were caused by the odontogenic origin. The prevalence of maxillary sinus abnormalities was higher in the symptomatic group than asymptomatic one (p<0.05). Conclusion: Maxillary sinus abnormalities were very common in the patients who were planning implantation in maxillary posterior areas. This result supports that thorough evaluation for maxillary sinus is recommended when implant treatment is planned for those areas.