공황장애의 암묵 및 외현기억 편향

정나영,채정호,이경욱,Jung, Na-Young,Chae, Jeong-Ho,Lee, Kyoung-Uk 대한불안의학회 2012 대한불안의학회지 Vol.8 No.1

Patients with panic disoder (PD) show recollection of their first panic attack, which resembles a trauma that is perceived as an unexpected frightening and subjectively life-threatening event. Information-processing models suggest that anxiety disorders may be characterized by a memory bias for threat-related information. This paper reviews the previous researches that investigated the implicit and/or explicit biases in patients with panic disorder. Among the 17 studies, which addressed the explicit memory bias in PD patients, 11 (64.7%) were found to be explicit memory bias in PD patients. In regards to the implicit memory bias, 4 out of 9 studies (44.4%) were found to support the memory bias. The result shows that evidence of explicit memory bias in PD patients was supported by a number of previous researches. However, evidence of implicit memory bias seems less robust, thus, needs further research for replication. Also, development of new paradigms and applications of various methods will be needed in further researches on memory bias in PD patients.

외국의 백신 능동적 감시 시스템 소개

정나영 ( Na-young Jeong ),박상신 ( Sangshin Park ),임은선 ( Eunsun Lim ),최남경 ( Nam-kyong Choi ) 한국보건정보통계학회(구 한국보건통계학회) 2019 한국보건정보통계학회지 Vol.44 No.4

Vaccines require higher safety standards than most other medicinal products because they are given to healthy individuals, including infants, children, and elderly. Despite various activities by national agencies, public concern about vaccine safety often arises. Post-marketing activities for vaccine safety can be broadly classified into passive and active surveillances. Many countries as well as Korea operate passive vaccine safety surveillance systems that report adverse events related to vaccines. However, the active surveillance systems operate only in several countries, such as the United States of America (USA), Europe, Canada and Australia. In the US, Vaccine Safety Datalink (VSD) and Post-Licensure Rapid Immunization Safety Monitoring (PRISM) were developed in 1990 and 2009 respectively for monitoring vaccine actively. In the case of Europe, the Vaccine Adverse Event Surveillance and Communication (VAESCO) consortium was launched in 2008. After the end of VAESCO, the Accelerated Development of VAccine beNefit-risk Collaboration in Europe (ADVANCE) was organized to establish a vaccine benefit-risk monitoring framework in 2013. Canada has been operating a vaccine active monitoring system known as the Canadian Immunization Monitoring Program, ACTive (IMPACT) since 1991. The objective of this review was to describe and compare background, databases, and analysis systems of various vaccine active surveillance systems in the US, Europe, and Canada. We described the examples of studies on the safety of influenza A (H1N1) vaccines carried out in each system. This review could help provide directions for the future development of the ideal active vaccine safety surveillance system in Korea.

유럽의 백신 유익성-위해성 감시를 위한 ADVANCE 프로젝트 소개

정나영 ( Na-young Jeong ),이해인 ( Hae-in Lee ),김민주 ( Min-ju Kim ),김희진 ( Hee-jin Kim ),최남경 ( Nam-kyong Choi ) 한국보건정보통계학회 2021 보건정보통계학회지 Vol.46 No.4

The vaccine benefit-risk assessment entails comprehensive and systematic evaluation of the major benefits and risks of vaccine based on information after a marketing authorization. In 2009, the influenza A (H1N1) pandemic led to the licensing of new H1N1 vaccines in many countries including Europe. The post-marketing evaluation and monitoring of H1N1 vaccines was carried out based on a project previously conducted in Europe. In 2013, the Accelerated Development of VAccine beNefit-risk Collaboration in Europe (ADVANCE) project was launched with the support of Innovative Medicines Initiative (IMI) to address the limitations reported in the previous project. ADVANCE consisted of seven Work Packages (WPs), each indicating the vaccine benefit-risk monitoring readiness across four areas: Governance, Data source, Methods, and Study. First, a model for vaccine surveillance and governance with various functions such as decision making, quality management, execution, and financial administration was established. Also, the project developed a tool to identify, collect, and link the data sources available for vaccine surveillance. In addition, various methodologies were reviewed to assess the infectious disease burden, vaccine coverage, and benefit-risk based on linked data sources in Europe. Guidelines were proposed for real-world vaccine surveillance studies. Accordingly, a variety of tools and programs were developed, including a code of conduct related to the benefit-risk assessment of vaccines, ADVANCE International Research Readiness (AIRR), CodeMapper, and VaccO. Since the end of the ADVANCE project in 2019, the Vaccine Monitoring Collaboration for Europe (VAC4EU) has been conducting effective and sustainable vaccine benefit-risk monitoring programs based on the vision and ideology of ADVANCE. This study explains the contents and findings of ADVANCE with emphasis on WPs and proposes directions for establishing a vaccine benefit-risk assessment system in Korea.

서울 일부지역 초등학교 고학년생의 영양지식, 식태도와 식행동

정나영(Na Young Jeong),김경원(Kyung Won Kim) 대한지역사회영양학회 2009 대한지역사회영양학회지 Vol.14 No.1

This study was aimed to examine nutrition knowledge, dietary attitudes, and eating habits of elementary school students and to examine if their characteristics differ by gender. Subjects were 5th and 6th graders of an elementary school (n=317) in Seoul, and the survey was done during July 2007. Mean height, weight, BMI of subjects was 148.1 cm. 41.7 kg, 19.0, and 14.3% of subjects were categorized as the overweight/obese group. Anthropometric data were not significantly different by gender. Mean score of nutrition knowledge was 14.9 out of 20 showing moderate knowledge levels, and girls scored higher on nutrition knowledge than boys (p<0.05). Subjects showed knowledge deficit in areas such as nutrients, food groups and specific weight control information. The percentages of correct answers regarding meals for brain function were significantly higher in girls than in boys (p<0.05). They got nutrition information mainly from mass media and family/relatives. The mean score of dietary attitudes was 41.2 (possible score: 10-50) indicating somewhat positive attitudes, and the score of eating behaviors was 34.8 (possible score: 15-45). Subjects showed problems in eating habits such as having unbalanced diets and snack foods. 82.6% of subjects had unbalanced meals, and these percentages were higher in girls (87.2%) than in boys (78.1%, p<0.05). Vegetables and fish/shellfish were the most disliked foods. Specific eating behaviors, such as eating slowly, eating grains and having processed foods less frequently, were better in girls than in boys (p<0.05). Results also showed that majority of subjects need to improve specific behaviors including having diverse foods, eating meals slowly, having meals at regular times, having adequate foods in each food groups, and eating sweets or salty foods less frequently. Only 52.7% of subjects perceived their body images as normal, and 56.4% had experience of weight control. Reasons for weight control were different by gender (p<0.05). Based on these findings, nutrition education for school children should focus on modifying eating habits or eating behaviors, by suggesting practically applicable methods and providing nutrition information that is interesting and suitable to school-aged children. (Korean J Community Nutrition 14(1):55~66, 2009)

국내 65세 이상 노인의 폐렴구균 23가 다당질 백신 접종 현황

김정아(Jeong Ah Kim),원희현(Heehyun Won),정나영(Na-Young Jeong),최남경(Nam-Kyong Choi) 대한약학회 2023 약학회지 Vol.67 No.4

Shadow IT를 고려한 새로운 관리체계 도입에 관한 연구

유지연(Ji Yeon Yoo),정나영(Na Young Jeong) 한국IT서비스학회 2016 한국IT서비스학회지 Vol.15 No.3

In a dynamic IT environment, employees often utilize external IT resources to work more efficiently and flexibly. However, the use of external IT resources beyond its control may cause difficulties in the company. This is known as “Shadow IT.” In spite of efficiency gains or cost savings, Shadow IT presents problems for companies such as the outflow of enterprise data. To address these problems, appropriate measures are required to maintain a balance between flexibility and control. Therefore, in this study, we developed a new information security management system called AIIMS (Advanced IT service & Information security Management System) and the Shadow IT Evaluation Model. The proposed model reflects a Shadow IT’s attributes such as innovativeness, effectiveness, and ripple effect. AIIMS consists of five fields: current analysis; Shadow IT management plans; management process; education and training; and internal audit. There are additional management items and sub-items within these five fields. Using AIIMS, we expect to not only mitigate the potential risks of Shadow IT but also create successful business outcomes. Now is the time to draw to the Light in the Shadow IT.

갈색거저리 유충 분말을 첨가한 도토리묵 품질평가

이경행 ( Kyung-haeng Lee ),윤영태 ( Young-tae Yoon ),박용이 ( Yong-i Park ),이혜진 ( Hye-jin Lee ),정나영 ( Na-young Jeong ) 한국식품영양학회 2017 韓國食品營養學會誌 Vol.30 No.5

In order to improve the usability of mealworm and the nutritional quality of acorn Mook mostly composed of carbohydrates, we prepared acorn Mook using with different levels of mealworm powder, and the physico-chemical and sensory evaluation were investigated. In the content of proximate chemical composition, moisture content did not show any significant difference. But crude protein, crude ash, and crude fat contents were increased with increasing mealworm content. Carbohydrate content was reduced as mealworm content increased. Lightness showed no significant difference among treatments, redness was increased, and yellowness was decreased as the amount of mealworm powder increased. In physiological properties, hardness, gumminess, chewiness, and springiness were significantly increased as the amount of mealworm powder decreased. However, adhesiveness and cohesiveness were not significantly different. Ascorbic acid content, activities of DPPH and ABTS radical scavenging activities were decreased with increasing amount of mealworm in acorn Mook. In sensory evaluation, acorn Mook containing 0.75% of mealworm powder showed highly preference compared with the control.

Apoptotic Effect of Co-Treatment with a Natural Product, Chios Gum Mastic, and a Synthetic Chenodeoxycholic Acid Derivative, HS-1200, on Human Osteosarcoma Cells

Ji-Hak Min(민지학),Min-Jeong Kim(김민정),In-Ryoung Kim(김인령),Seung-Eun Lee(이승은),Hyun-Ho Kwak(곽현호),Gyoo-Cheon Kim(김규천),Hae-Ryoun Park(박혜련),Sang-Hun Shin(신상훈),Chul-Hoon Kim(김철훈),Na-Young Jeong(정나영),Hongsuk Suh 대한체질인류학회 2008 대한체질인류학회지 Vol.21 No.2

Chios gum mastic(CGM)은 그리이스 지역에서만 서식하는 Pistacia lenticulus 나무의 줄기와 잎에서 추출한 수지상의 천연 추출물이다. 합성 chenodeoxycholic acid(CDCA) 유E씨가 여러 가지 암세포에 유도한 세포자멸사 연구들이 보고되어져 왔다. 본 연구는 천연물질인 CGM과 항성 CDCA 유도체인 HS-1200의 병용처리가 사람골육종세포에 효과적인 상승 세포자멸사 효과가 있는지를 알기 위해서 수행되었다. CDM과 HS-1200의 병용처리가 단독처리에 비해서 효과적인 세포생존율 감소가 있는지 확인하기 위해서 MIT법을 시행하였고, 세포자멸사의 유도와 증가를 확인하기 위해서 Hoechst 염색법과 DNA 전기영동법을 사용하였다. 병용처리 때, 세포자멸사에 관계하는 단백질의 발현 변화와 세포내에서의 이동을 밝혀내기 위해서 Western bot 분석과 면역형광염색법을 수행하였다. 더 나아가서 proteasome 활성도와 사립체막 전위 변화를 측정하였다. 병용처리 된 사람골육종세포는 단독처리 된 사람골육종세포에서 거의 관찰할 수 없었던 많은 핵 응축, DNA 조각남, 사립체막 전위와 proteasome 활성도의 감소, DNA 양의 감소, cytochrome c의 세포질로의 유리, AIF와 DFF40(CAD)의 핵으로의 이동, caspase-7, caspase-3 그리고 PARP의 활성화와 같은 세포자멸사 증거를 보였다. 24시간 동안 40㎍/mL CGM과 25μM HS-1200을 각기 단독처리 한 결과에서는 세포자멸사를 유도 못했으나, 병용처리한 결과에는 아주 탁월한 세포자멸사의 유도를 보였다. 이러한 병용처리 결과는 사람골육종의 새로운 치료적 전략으로 응용될 수 있다고 생각한다. Chios gum mastic (CGM) is a resinous exudate obtained from the stem and the main leaves of Pistacia lenticulus tree native to Mediterranean areas. Recently it reported that CGM induced apoptosis in a few cancer cells in vitro. It has been reported that the synthetic chenodeoxycholic acid (CDCA) derivatives showed apoptosis-inducing activity on various cancer cells in vitro. This study was undertaken to investigate the synergistic apoptotic effect of co-treatment with a natural product, CGM and a CDCA derivative, HS-1200 on human osteosarcoma (HOS) cells. To investigate whether the co-treatment of CGM and HS-1200 compared with each single treatment efficiently reduced the viability of HDS cells, MTT assay was conducted. Induction and augmentation of apoptosis were confirmed by DNA electrophoresis, Hoechst staining and DNA hypoploidy, Westen blot analysis and immuno-fluorescent staining were performed to study the alterations of the expression level and translocation of apoptosis-related proteins in co-treatment. Furthermore, proteasome activity and mitochondrial membrane potential (MMP) change were also assayed. In this study, HOS cells co-treated with CGM and HS-1200 showed several lines of apoptotic manifestation whereas each single treated HOS cells did not. Although the single treatment of 40 ㎍/㎖, CGM or 25 μM HS-1200 for 24 h did not induce apoptosis, the co-treatment of them induced prominently apoptosis. Therefore our data provide the possibility that combination therapy of CGM and HS-1200 could be considered as a novel therapeutic strategy for human osteosarcoma.

염색조건에 따른 양파껍질의 염색효과에 관한 연구

정나영,이전숙,최경은 한국가정과학회 2000 한국가정과학회지 Vol.3 No.1

The purpose of this study was to identify the best dyeing conditions using onion's outer shell, and to apply to the method in practical daily life. To do this, we extracted quercetin from onion's outer shell and dyed several natural fabrics such as cotton, slack mercerized cotton, ramie, and silk, under the different conditions. Dyed fabrics were investigated in the aspect of dyeability and colorfastness. The effective conditions for the light-fastness and washing-fastness also have been studied. The results of the experiment were varied with such conditions as temperature, time, pH degree, and treatment and types of mordants. The results are as follows : 1. Fabrics dyed with onion's outer shell showed excellent dyeability even though there were no mordants, and the silk fabric dyed better than both cotton and ramie fabric. Furthermore, in the cases of repeated dyeing and treatment of mordants using AIK(SO_4)_2·12H_2O and CuSO_4,·5H_2O dyeability of specimen had been improved 2. Cellulose fabrics such as cotton, mercerized cotton and ramie showed the best dyeability under relatively low temperature in the range of 20∼40℃. On the contrary to cellulose fabric, silk fabric showed the best dyeability under higher dyeing temperature. All fabrics had the higest K/S value at pH 3 regardless of the kind of fiber. 3. Dyeing colors varied with the kind of mordants. Colors were turned into yellow in AIK(SO_4)_2·12H_2O into yellow-red in CuSO_4·5H_2O, and into green-yellow in FeSO_4·7H_2O. As mordants, AlK(SO_4)_2·12H_2O, CuSO_4·5H_2O, FeSO_4 ·7H_2O, gallic acid and tartaric acid were used and especially A1K(S0_4)_2·12H_20 showed the best dyeability and colorfastness in repeated dyeing. Mordants such as A1K(SO_4)_2·12H_2O made fabrics have better chroma and washing-fastness though the light-fastness was poorer than non mordanting. 4. Repeated dyeing brought us deep color. When fresh dyebath was used each time, the dyeability was increased as the experiment was repeated more. When dyed with used dyebath several times, improved dyeability could not be expected. The optimal using times of the used dyebath was twice.

유아의 거친 신체놀이 참여 정도에 따른 정서지능 및 친사회적 행동 차이

정나영,정계숙 부산대학교 과학교육연구소 2016 교사교육연구 Vol.55 No.1

The purpose of this study was to examine the differences of the rough-and-tumble play among preschoolers according to their emotional intelligence and pro-social behavior. The subjects of this study were 350 preschoolers aged four to five years old. A questionnaire which are rough-and-tumble play, emotion intelligence, pro-social behavior, and a coping checklist was given to the teachers. From the 350 questionnaires returned 300 were finally analyzed based on sufficient data. The collected data was analyzed according to a frequency analysis and t-test using the statistical package SPSS 18.0 program. The results of this study were as follows. First, the preschooler``s rough-and-tumble play most frequently displayed was running and chasing in which boys were more likely to participate in than girls. Second, there were differences among the preschoolers emotion intelligence according to their level of rough-and-tumble play. Preschoolers who participated in more rough-and-tumble play showed more emotion intelligence than those who participated in less rough-and-tumble play. These differences in emotional intelligence included: more appraisal and expression of self emotion, more developed relationship with the teacher, and more developed relationship with their peers. Third, there were differences among the preschooler’s pro-social behavior according to their level of rough-and-tumble play. Preschoolers who participated in more rough-and-tumble play showed better pro-social behavior than those who participated in less rough-and-tumble play. These differences in pro-social behaviors included: a higher likelihood to help others, active communication, a higher willingness to help, higher comfort levels of proximity, more willing to share, and a deeper display of empathy. 본 연구는 유아의 거친 신체놀이 참여 정도에 따라 정서지능과 친사회적 행동에 차이가 있는지 알아보고자 하였다. 이를 위해 경상도와 경기도에 소개하고 있는 유치원 및 어린이집에 재원 중인 만 4, 5세 유아 300명을 최종 연구대상으로 하였다. 유아의 거친 신체놀이, 정서지능, 친사회적 행동의 측정은 거친 신체놀이 11문항, 정서지능 50문항, 친사회적 행동 42문항으로 구성된 교사용 척도를 사용하였다. 연구문제에 따라 분석한 결과는 다음과 같다. 첫째, 유아의 거친 신체놀이 참여 빈도를 알아 본 결과, 유아들은 거친 신체놀이에서 도망가기와 쫓기를 가장 많이 하였고, 몰래 다가가 놀래키기를 가장 적게 하였다. 또한 거친 신체놀이에 따라 대한 유아 성별의 차이를 알아본 결과, 남아가 여아보다 거친 신체놀이를 많이 하는 것으로 나타났다. 둘째, 유아의 거친 신체놀이 참여 정도에 따라 정서지능을 알아본 결과, 거친 신체놀이 참여도가 높은 집단의 정서지능의 점수가 더 높았다. 셋째, 유아의 거친 신체놀이 참여 정도에 따라 친사회적 행동의 차이를 알아본 결과, 거친 신체놀이 참여도가 높은 집단의 친사회적 행동 점수가 더 높게 나타났다.