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Helicobacter pylori의 초기 박멸요법 후 궤양치유를 위한 추가적인 산억제제가 필요한가 ?
정재진(Jae Jin Jung),이동욱(Dong Wook Lee),이동수(Dong Su Lee),정강욱(Kang Wook Chung),김영성(Young Sung Kim),김은영(Eun Young Kim),손수호(Soo Ho Son),여준기(Jun Ki Yeo),곽동협(Dong Hyup Kwak) 대한내과학회 2001 대한내과학회지 Vol.60 No.5
N/A Background : Helicobacter pylori (H. pylori) can now be eradicated in the majority of patients with 7 days of treatment with OAC ( omeprazole + amoxicillin + clarithromycin ) regimen. It is unclear if additional acid-suppressing treatment should be continued beyond 7 days in patients with active gastric or duodenal ulcers. Methods : Ninety two patients with endoscopically proven active peptic ulcers who were H. pylori positive were randomized to receive either omeprazole 20 mg plus amoxicillin 1.0g plus clarithromycin 500mg ; twice daily for 1 week alone (OAC group) or same regimen followed by 3 weeks of omeprazole (OACP group). Endoscopy and UBT (urea breath test) were performed 8 weeks after the initiation of treatment. Results: Forty four of forty five (97.8%) of OAC group and forty four of forty seven (93.6%) of OACP group were noted to have healed ulcer at week 8. Conclusion: In patients with H. pylori infection and peptic ulcers, one week of OAC therapy without further need for PPI may heal the ulcers. Following an l week course of H. pylori eradication therapy by OAC for peptic ulcers, further 3 weeks of acid-suppressing therapy with PPI was not proven to promote ulcer healing rate.(Korean J Med 60:439-443, 2001)