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간장 및 담도 : Ketoconazole 에 의한 독성간염 4예
강진경(Jin Kyung Kang),박찬일(Chan Il Park),김경희(Kyung Hee Kim),민희원(Hee Won Min),오광제(koyang Jae Oh),김형중(Hyung Jung Kim),전재윤(Jae Youn Jun),정재복(Jae Bock Jung),정우희(Woo Hee Jung) 대한소화기학회 1986 대한소화기학회지 Vol.18 No.1
N/A Ketoconazole is the broad-spectrum antifungal ageht as an imidazole-dioxolane compound which is metabolized chiefly in the liver. It is used in onychomycosis, chronic mucocutaneous candidiasis, systemic fungal infection, and vaginal candidiasis that is chronic or not healed with topical treatment. Side reactions of ketoconazole are seen in 5%~10% of all the patients medicated but most of them are mild and transient. Nausea and vomiting are the most frequent side reactions. In addition, there are abdominal pain, headache, dizziness, itching sensation, fever, photophobia, diarrhea and transient elevation of serum hepatic enzyme level. However, symptoms of hepatitis develop rarely. In 1984, Lewis and co-workers reported 33 cases of ketoconazole- induced hepatitis and this kind of hepatitis has already been reported twice in Korea. In recent time we experienced 4 cases of hepatitis which had seemed as acute or chronic hepatitis clinically, but had confirmed with peritoneoscopic liver biopsy as toxic hepatitis developed after longterm use of ketoconazole.
원발성 간암과 감별이 어려웠던 비전형적인 간혈관종 1예
최병현,김진석,조영준,전재윤,한광협,문영명,백용한,정재연,고준상 대한소화기학회 2000 대한소화기학회지 Vol.35 No.2
Hepatocellular carcinoma is one of the major cancers in Korea. Early detection and diagnosis are the most important for the treatment of hepatocellular carcinoma. Ultrasonography combined with the measurement of serum α-fetoprotein is an effective screening method to detect small hepatocellular carcinoma. A 53-year-old man who had chronic hepatitis B was referred to our hospital under the suspicion of having hepatocellular carcinoma. Ultrasonogrphy had revealed a 3 cm diameter hyperechoic mass, suggesting hemangioma. Magnetic resonance (MR) imaging was performed for suspicion of having hepatocellular carcinoma due to elevated serum α-fetoprotein level. Since MR imaging was consistent with possible hepatocellular carcinoma, but not specific for hemangioma, red blood cell scan, needle aspiration biopsy, and angiography were performed. However, those results were not conclusive. Thus, the patient was followed at regular intervals. Since serum α-fetoprotein level became normal, but tumor size was not changed dng long term follow-up, we diagnosed the lesion as atypical hemangioma.