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간장 및 담도 : Ketoconazole 에 의한 독성간염 4예
강진경(Jin Kyung Kang),박찬일(Chan Il Park),김경희(Kyung Hee Kim),민희원(Hee Won Min),오광제(koyang Jae Oh),김형중(Hyung Jung Kim),전재윤(Jae Youn Jun),정재복(Jae Bock Jung),정우희(Woo Hee Jung) 대한소화기학회 1986 대한소화기학회지 Vol.18 No.1
N/A Ketoconazole is the broad-spectrum antifungal ageht as an imidazole-dioxolane compound which is metabolized chiefly in the liver. It is used in onychomycosis, chronic mucocutaneous candidiasis, systemic fungal infection, and vaginal candidiasis that is chronic or not healed with topical treatment. Side reactions of ketoconazole are seen in 5%~10% of all the patients medicated but most of them are mild and transient. Nausea and vomiting are the most frequent side reactions. In addition, there are abdominal pain, headache, dizziness, itching sensation, fever, photophobia, diarrhea and transient elevation of serum hepatic enzyme level. However, symptoms of hepatitis develop rarely. In 1984, Lewis and co-workers reported 33 cases of ketoconazole- induced hepatitis and this kind of hepatitis has already been reported twice in Korea. In recent time we experienced 4 cases of hepatitis which had seemed as acute or chronic hepatitis clinically, but had confirmed with peritoneoscopic liver biopsy as toxic hepatitis developed after longterm use of ketoconazole.